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NCT06657976 · ClinicalTrials.gov registry record · Phase 2
Response to Exercise and Nitric Oxide in PAD
A Phase 2 study of Exercise and Peripheral Artery Disease, sponsored by Northwestern University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 200
- Enrollment target
- 2
- Study locations
NCT06657976: Recruiting Phase 2 study of Exercise and Peripheral Artery Disease, sponsored by Northwestern University.
NCT06657976 is a Phase 2 study of Exercise and Peripheral Artery Disease that is actively recruiting participants, run by Northwestern University. The registered enrollment target is 200 participants, below the 8,907-participant average among 57 other Exercise trials with a reported enrollment target (98% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06657976, a Phase 2 study of Exercise and Peripheral Artery Disease, is actively recruiting participants, sponsored by Northwestern University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 200 participants
- Enrollment target
- 2
- Study locations
Study Summary
RESIST PAD is a randomized trial of 200 PAD patients to establish: 1) whether a 12-week exercise intervention significantly increases Δ nitrite at 12-week follow-up, compared to control; 2) whether exercise "responders" have greater Δ nitrite increases compared to "non-responders"; 3) among non-responders, whether supplementing exercise with nitrate-rich beetroot juice between weeks 13-24 increases Δ nitrite and improves 6-minute walk at 24-week follow-up.
Primary Outcome
Change in plasma nitrite from the beginning to the end of a maximal exercise stress test
Conditions Studied
Interventions
- BEHAVIORAL Attention Control
- BEHAVIORAL Supervised Treadmill Exercise
- COMBINATION_PRODUCT Nitrate-Rich Beetroot Juice + supervised exercise therapy
- COMBINATION_PRODUCT Placebo + supervised exercise therapy
Study Locations (2)
Illinois
- Northwestern University Feinberg School of Medicine - Chicago
- University of Chicago - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2025-01-23 |
| Est. Completion | 2029-10-01 |
| Phase | Phase 2 |
What NCT06657976 shows while recruiting
NCT06657976 is an interventional study that assigns participants to a tested intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 8,907-participant average among 57 other Exercise trials with a reported enrollment target (98% lower).
The record links to 4 conditions, with Exercise appearing as the primary indexed condition, and to 4 interventions - of which Attention Control is the first listed.
NCT06657976 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT06657976 about?
NCT06657976 is a clinical study titled "Response to Exercise and Nitric Oxide in PAD". RESIST PAD is a randomized trial of 200 PAD patients to establish: 1) whether a 12-week exercise intervention significantly increases Δ nitrite at 12-week follow-up, compared to control; 2) whether exercise "responders" have greater Δ nitrite increases compared to "non-responders"; 3) among non-resp...
What is the current status of trial NCT06657976?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 200 participants. The study started on 2025-01-23. Estimated completion is 2029-10-01.
What conditions does trial NCT06657976 study?
This clinical trial studies the following conditions: Exercise, Peripheral Artery Disease, Intermittent Claudication, Nitric Oxide.
What interventions are being tested in trial NCT06657976?
The interventions under investigation include: Attention Control (BEHAVIORAL), Supervised Treadmill Exercise (BEHAVIORAL), Nitrate-Rich Beetroot Juice + supervised exercise therapy (COMBINATION_PRODUCT), Placebo + supervised exercise therapy (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT06657976?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06657976 being conducted?
This trial has 2 study locations across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Exercise
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06657976's enrollment target sits among peer trials
200 9th of 57 higher than 46 of 57 other Exercise trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Exercise trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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