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Efficacy of Methylprednisolone for Pain Control After ACL Repair
NCT07158476 · View on ClinicalTrials.gov ↗
Study Summary
Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL repair surgery to determine if this results in decreased postoperative pain and opioid use without increasing complications.
Conditions Studied
Interventions
- DRUG Meloxicam 15 mg
- DRUG Medrol 4 MG Oral Tablet Includes Medrol Dosepak
- DRUG Gabapentin 300 mg
- DRUG Hydrocodone 5Mg/Acetaminophen 325Mg Tab
- DRUG Ketorolac 10 Mg Oral Tablet
Study Locations (1)
Missouri
- Saint Louis University — St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2025-10-21 |
| Est. Completion | 2031-09 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07158476
The ClinicalTrials.gov registry entry for NCT07158476 describes a study currently listed as recruiting. It is categorized as Phase 4, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is St. Louis University, which has 35 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Pain Management appearing as the primary indexed condition, and to 5 interventions — of which Meloxicam 15 mg is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07158476 reports 1 study location spanning 1 distinct geographic area — top geographies include Missouri. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07158476 about?
NCT07158476 is a clinical study titled "Efficacy of Methylprednisolone for Pain Control After ACL Repair". Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL repa...
What is the current status of trial NCT07158476?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 90 participants. The study started on 2025-10-21. Estimated completion is 2031-09.
What conditions does trial NCT07158476 study?
This clinical trial studies the following conditions: Pain Management, ACL Surgery. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07158476?
The interventions under investigation include: Meloxicam 15 mg (DRUG), Medrol 4 MG Oral Tablet Includes Medrol Dosepak (DRUG), Gabapentin 300 mg (DRUG), Hydrocodone 5Mg/Acetaminophen 325Mg Tab (DRUG), Ketorolac 10 Mg Oral Tablet (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07158476?
This trial is sponsored by St. Louis University, which has 35 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07158476 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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