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ClinicalTrials.gov 11 recruiting now official registry

Oropharyngeal Squamous Cell Carcinoma clinical trials

11 of 15 indexed Oropharyngeal Squamous Cell Carcinoma trials are currently recruiting.

15 US clinical trials · 11 currently recruiting

Oropharyngeal Squamous Cell Carcinoma is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 2 of these trials.

The research picture

Oropharyngeal Squamous Cell Carcinoma has 15 registered US clinical trials, 11 of them open to new participants right now, about 73% of the total.

11
recruiting participants now
73%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: National Cancer Institute (NCI)
Phase 11Phase 28

Active & Recent Trials

15 total, page 1 of 1

RECRUITING 1,000 participants

Validity of Viome's Oral/throat Cancer Test

Viome

NCT06174428

RECRUITING 440 participants

Oropharynx (OPX) Biomarker Trial

Mayo Clinic

NCT06356272

RECRUITING Phase 2 250 participants

Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma

University of Florida

NCT05268614

RECRUITING 220 participants

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

UNC Lineberger Comprehensive Cancer Center

NCT04564989

RECRUITING 144 participants

People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity

University of California, San Francisco

NCT06055868

RECRUITING Phase 2 98 participants

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

NRG Oncology

NCT06532279

RECRUITING Phase 2 45 participants

Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer

Ohio State University Comprehensive Cancer Center

NCT06323460

RECRUITING Phase 2 44 participants

Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

National Cancer Institute (NCI)

NCT06980038

RECRUITING Phase 2 42 participants

Shortened Course of Radiation Therapy After Trans-oral Robotic Surgery in Patients With HPV-Mediated Oropharyngeal Squamous Cell Carcinoma.

University of Utah

NCT07044635

RECRUITING Phase 2 30 participants

Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma

Washington University School of Medicine

NCT04852328

RECRUITING Early Phase 1 20 participants

Comparing an Investigational Scan (F-18 NaF PET/CT) to Standard of Care Imaging (F-18 FDG PET/CT) for Evaluating Vascular Complications in Patients Receiving Radiation Therapy for Head and Neck Cancer

Emory University

NCT06914999

ACTIVE NOT RECRUITING Phase 2 384 participants

De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer

National Cancer Institute (NCI)

NCT03952585

ACTIVE NOT RECRUITING 150 participants

Post-treatment Surveillance in HPV+ Oropharyngeal SCC

Dana-Farber Cancer Institute

NCT04965792

ACTIVE NOT RECRUITING Phase 2 52 participants

Selective Avoidance of Nodal VolumEs at Minimal Risk (GCC 20110)

University of Maryland, Baltimore

NCT04609280

COMPLETED NA 112 participants

The Sinai Robotic Surgery Trial in HPV Positive Oropharyngeal Squamous Cell Carcinoma (SCCA) (SIRS TRIAL)

Icahn School of Medicine at Mount Sinai

NCT02072148

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Oropharyngeal Squamous Cell Carcinoma Trial Landscape

15 indexed Oropharyngeal Squamous Cell Carcinoma studies · 11 recruiting (73%).

Phase mix: 0 late (III/IV) vs 9 early (I/II).

Top sponsor: National Cancer Institute (NCI) (2 trials), 9 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Oropharyngeal Squamous Cell Carcinoma?

PlainTrial tracks 15 US clinical trials for Oropharyngeal Squamous Cell Carcinoma, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Oropharyngeal Squamous Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.