Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Oropharyngeal Cancer

Open-data reference.

26 US clinical trials · 10 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 510 participants

SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer

Canadian Cancer Trials Group

NCT05451004

RECRUITING 400 participants

Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)

H. Lee Moffitt Cancer Center and Research Institute

NCT06305676

RECRUITING Phase 2 150 participants

A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze)

University of Michigan Rogel Cancer Center

NCT05894083

RECRUITING Phase 2 121 participants

A Study of Reduced Radiation Therapy and Standard-of-Care Chemotherapy in People With HPV-Positive Throat Cancer

Memorial Sloan Kettering Cancer Center

NCT05491512

RECRUITING 80 participants

Liposomal Bupivacaine and Transoral Robotic Surgery

Geisinger Clinic

NCT05862792

RECRUITING Phase 2 75 participants

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT07209189

RECRUITING Phase 2 50 participants

Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer

Zachary Zumsteg

NCT06445114

RECRUITING Phase 2 30 participants

Toripalimab in Combination With Standard Treatment for Human Papillomavirus (HPV) Positive Throat Cancer

University of Chicago

NCT07290621

RECRUITING Phase 1 30 participants

Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery

Ryan Carey

NCT06747390

RECRUITING Phase 2 20 participants

BALSTILIMAB on Viral Clearance in HPV+ Oropharyngeal Cancer Patients

M.D. Anderson Cancer Center

NCT05363709

ACTIVE NOT RECRUITING 1,500 participants

Men and Women Offering Understanding of Throat HPV

Johns Hopkins University

NCT03644563

ACTIVE NOT RECRUITING NA 643 participants

Enhancing Self Care Among Oral Cancer Survivors: The Empowered Survival Trial

Rutgers, The State University of New Jersey

NCT04713449

ACTIVE NOT RECRUITING 185 participants

Depression and Adherence in Head and Neck Cancer

M.D. Anderson Cancer Center

NCT00498875

ACTIVE NOT RECRUITING NA 150 participants

TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck

Abramson Cancer Center at Penn Medicine

NCT03729518

ACTIVE NOT RECRUITING Phase 2 90 participants

Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer

M.D. Anderson Cancer Center

NCT03224000

ACTIVE NOT RECRUITING 75 participants

EValuating the Safety Of De-escaLated Head and Neck Irradiation in HPV positivE Oropharynx Cancer in Non-smokers/Minimal Smokers

Sanford Health

NCT03777384

ACTIVE NOT RECRUITING Phase 1 55 participants

A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers

National Cancer Institute (NCI)

NCT04708470

ACTIVE NOT RECRUITING Phase 1 51 participants

Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies

National Cancer Institute (NCI)

NCT04287868

ACTIVE NOT RECRUITING Phase 1 39 participants

HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers

National Cancer Institute (NCI)

NCT04432597

ACTIVE NOT RECRUITING 9 participants

A Study Using Human Papillomavirus (HPV) DNA Testing to Detect HPV-Related Oropharyngeal Cancer (OPC)

Memorial Sloan Kettering Cancer Center

NCT05814549

COMPLETED 252 participants

Sexual Behavior in Oropharyngeal Patients Versus Head and Neck Cancer Patients, With or Without HPV Infection

M.D. Anderson Cancer Center

NCT00508170

COMPLETED 115 participants

Nicotine Levels With Response Rates to Radiation Alone or With Chemo In Head & Neck Cancer

Mahesh Kudrimoti

NCT01084733

COMPLETED 33 participants

Role of Immune Activation in Response of Head and Neck Squamous Cell Carcinoma to Therapy

Icahn School of Medicine at Mount Sinai

NCT01358097

COMPLETED NA 33 participants

Prospective, Multicenter da Vinci® SP™ Surgical System TORS Study

Intuitive Surgical

NCT03049280

COMPLETED NA 25 participants

A Pilot Trial of Image-Guided Adaptive Radiotherapy for Head and Neck Cancer

M.D. Anderson Cancer Center

NCT00490282

COMPLETED Phase 1 24 participants

HYHOPE: De-intensified Hypofractionated Radiation Therapy for HPV-associated Oropharynx Cancer

University of Texas Southwestern Medical Center

NCT04580446

Phase Distribution

PhaseTrial count
Early Phase 1 5
Phase 2 7
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Oropharyngeal Cancer Trial Landscape

ClinicalTrials.gov lists 26 US studies indexed under Oropharyngeal Cancer, and 10 of those are currently open to recruitment — roughly 38% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Oropharyngeal Cancer shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 12 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Oropharyngeal Cancer is led by M.D. Anderson Cancer Center with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 26 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Oropharyngeal Cancer?

PlainTrial tracks 26 US clinical trials for Oropharyngeal Cancer, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Oropharyngeal Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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