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NCT07290621 · ClinicalTrials.gov registry record · Phase 2
Toripalimab in Combination With Standard Treatment for Human Papillomavirus (HPV) Positive Throat Cancer
A Phase 2 study of Oropharyngeal Cancer, sponsored by University of Chicago.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT07290621: Recruiting Phase 2 study of Oropharyngeal Cancer, sponsored by University of Chicago.
NCT07290621 is a Phase 2 study of Oropharyngeal Cancer that is actively recruiting participants, run by University of Chicago. The registered enrollment target is 30 participants, below the 189-participant average among 25 other Oropharyngeal Cancer trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07290621, a Phase 2 study of Oropharyngeal Cancer, is actively recruiting participants, sponsored by University of Chicago.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a single-center phase 2 study of to test how well the combination of toripalimab with chemotherapy followed by TORS or risk and response stratified de-escalated (chemo)radiotherapy works in patients with in HPV16+ locoregionally advanced oropharyngeal cancer (OPC).
Primary Outcome
The proportion of patients who attain a deep response following neoadjuvant toriaplimab + chemotherapy. DDR is defined as tumor shrinkage by 50% or more.
Conditions Studied
Interventions
- DRUG Carboplatin
- DRUG Paclitaxel
- DRUG Toripalimab
Study Locations (1)
Illinois
- The University of Chicago Medicine Comprehensive Cancer Center - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-02 |
| Est. Completion | 2033-02 |
| Phase | Phase 2 |
What NCT07290621 shows while recruiting
NCT07290621 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 189-participant average among 25 other Oropharyngeal Cancer trials with a reported enrollment target (84% lower).
The record links to 1 condition, with Oropharyngeal Cancer appearing as the primary indexed condition, and to 3 interventions - of which Carboplatin is the first listed.
NCT07290621 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT07290621 about?
NCT07290621 is a clinical study titled "Toripalimab in Combination With Standard Treatment for Human Papillomavirus (HPV) Positive Throat Cancer". This is a single-center phase 2 study of to test how well the combination of toripalimab with chemotherapy followed by TORS or risk and response stratified de-escalated (chemo)radiotherapy works in patients with in HPV16+ locoregionally advanced oropharyngeal cancer (OPC).
What is the current status of trial NCT07290621?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 30 participants. The study started on 2026-02. Estimated completion is 2033-02.
What conditions does trial NCT07290621 study?
This clinical trial studies the following conditions: Oropharyngeal Cancer.
What interventions are being tested in trial NCT07290621?
The interventions under investigation include: Carboplatin (DRUG), Paclitaxel (DRUG), Toripalimab (DRUG).
Who is sponsoring clinical trial NCT07290621?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07290621 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Oropharyngeal Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07290621's enrollment target sits among peer trials
30 21st of 25 higher than 4 of 25 other Oropharyngeal Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Oropharyngeal Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
BALSTILIMAB on Viral Clearance in HPV+ Oropharyngeal Cancer Patients
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-
A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze)
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A Study of Reduced Radiation Therapy and Standard-of-Care Chemotherapy in People With HPV-Positive Throat Cancer
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Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)
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Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer
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-
Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer
ACTIVE NOT RECRUITING · Phase 2
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