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NCT06445114 · ClinicalTrials.gov registry record · Phase 2
Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer
A Phase 2 study of Carcinoma and Oropharyngeal Cancer, sponsored by Zachary Zumsteg.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 50
- Enrollment target
- 4
- Study locations
NCT06445114: Recruiting Phase 2 study of Carcinoma and Oropharyngeal Cancer, sponsored by Zachary Zumsteg.
NCT06445114 is a Phase 2 study of Carcinoma and Oropharyngeal Cancer that is actively recruiting participants, run by Zachary Zumsteg. The registered enrollment target is 50 participants, below the 253-participant average among 29 other Carcinoma trials with a reported enrollment target (80% lower). The trial reports 4 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06445114, a Phase 2 study of Carcinoma and Oropharyngeal Cancer, is actively recruiting participants, sponsored by Zachary Zumsteg.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 50 participants
- Enrollment target
- 4
- Study locations
Study Summary
This is a single institution phase II study that will enroll patients with T0-3N0-2 p16-positive oropharyngeal squamous cell carcinoma (OSCC) undergoing resection of all gross visible disease at the primary site and in the lymph nodes.
Primary Outcome
The primary objective of this study is to assess the 2-year progression-free survival (PFS) of de-intensified post-operative chemoradiation in patients with HPV-associated oropharyngeal cancer when basing treatment intensity on both standard pathologic features and post-operative Blood-based circulating tumor tissue modified viral (cTTMV-HPV DNA)
Conditions Studied
Interventions
- DRUG Cisplatin
Study Locations (4)
California
- Cedars-Sinai Cancer at Beverly Hills (THO) - Beverly Hills
- Cedars Sinai Medical Center - Los Angeles
- CS Cancer at Valley Oncology Medical Group - Tarzana
- CS Cancer at the Hunt Cancer Center - Torrance
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-05-12 |
| Est. Completion | 2032-06 |
| Phase | Phase 2 |
What NCT06445114 shows while recruiting
NCT06445114 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 253-participant average among 29 other Carcinoma trials with a reported enrollment target (80% lower).
The record links to 2 conditions, with Carcinoma appearing as the primary indexed condition, and to 1 intervention - of which Cisplatin is the first listed.
NCT06445114 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06445114 about?
NCT06445114 is a clinical study titled "Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer". This is a single institution phase II study that will enroll patients with T0-3N0-2 p16-positive oropharyngeal squamous cell carcinoma (OSCC) undergoing resection of all gross visible disease at the primary site and in the lymph nodes.
What is the current status of trial NCT06445114?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2025-05-12. Estimated completion is 2032-06.
What conditions does trial NCT06445114 study?
This clinical trial studies the following conditions: Carcinoma, Oropharyngeal Cancer.
What interventions are being tested in trial NCT06445114?
The interventions under investigation include: Cisplatin (DRUG).
Who is sponsoring clinical trial NCT06445114?
This trial is sponsored by Zachary Zumsteg, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06445114 being conducted?
This trial has 4 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Carcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06445114's enrollment target sits among peer trials
50 21st of 29 higher than 9 of 29 other Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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