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ClinicalTrials.gov 8 recruiting now official registry

Opioid-Related Disorders clinical trials

8 of 59 indexed Opioid-Related Disorders trials are currently recruiting.

59 US clinical trials · 8 currently recruiting

Opioid-Related Disorders is the subject of 59 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 25 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute on Drug Abuse (NIDA), running 10 of these trials.

The research picture

Opioid-Related Disorders has 59 registered US clinical trials, 8 of them open to new participants right now, about 14% of the total.

8
recruiting participants now
14%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
10
top sponsor: National Institute on Drug Abuse (NIDA)
Phase 16Phase 219Phase 37Phase 43

Active & Recent Trials

59 total, page 1 of 2

RECRUITING NA 2,000 participants

Developing and Evaluating a Machine-Learning Opioid Overdose Prediction & Risk-Stratification Tool in Primary Care

University of Pittsburgh

NCT06810076

RECRUITING Phase 3 300 participants

Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits

University of Utah

NCT06387290

RECRUITING Phase 2 255 participants

Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder

University of Arkansas

NCT05336188

RECRUITING 240 participants

fMRI and Opioid Abstinence

Yale University

NCT06651333

RECRUITING 150 participants

Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

National Institute on Drug Abuse (NIDA)

NCT03745339

RECRUITING NA 75 participants

Developing a Smartphone Application to Support Veteran Opioid Use Disorder Treatment

VA Office of Research and Development

NCT06454903

RECRUITING Phase 1 24 participants

STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis

Indiana University

NCT05603702

RECRUITING Phase 2 15 participants

Psilocybin in Cancer Pain Study

Yvan Beaussant, MD, MSci

NCT06001749

ACTIVE NOT RECRUITING NA 805 participants

More Individualized Care: Assessment and Recovery Through Engagement

Kaiser Permanente

NCT05122676

ACTIVE NOT RECRUITING NA 752 participants

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

April M Young

NCT05657106

ACTIVE NOT RECRUITING NA 400 participants

Developing a Tailored Stigma Reduction Intervention to Increase Buprenorphine Prescribing

Ohio University

NCT05505227

ACTIVE NOT RECRUITING NA 350 participants

Healthy Opioid Prescription Engagement

Jerry Cochran

NCT05141266

ACTIVE NOT RECRUITING NA 250 participants

OUD Smartphone Services

Western Michigan University

NCT06134882

ACTIVE NOT RECRUITING Phase 3 144 participants

Extended-release Buprenorphine Compared to Sublingual Buprenorphine in Rural Settings (RXR)

Yih-Ing Hser

NCT06023459

ACTIVE NOT RECRUITING Early Phase 1 12 participants

Tau PET Imaging in Opioid Use Disorder

University of Pennsylvania

NCT05651516

ACTIVE NOT RECRUITING NA 4 participants

Feasibility of Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder

West Virginia University

NCT03950492

COMPLETED 5,411 participants

Comparing State Payer Strategies to Prevent Unsafe Opioid Prescribing

University of Washington

NCT03932799

COMPLETED NA 948 participants

Addressing Origins of the Opioid Epidemic by Improving Prescribing for Opioid-Naive Patients

Weill Medical College of Cornell University

NCT03377855

COMPLETED Phase 3 665 participants

Treatment Seeking Participants With Opioid Use Disorders Assessing Tolerability of Depot Injections of Buprenorphine

Indivior

NCT02357901

COMPLETED 534 participants

An Observational Study of Environmental and SocioEconomic Factors in Opioid Recovery

Indivior

NCT03604861

COMPLETED Phase 4 374 participants

The Kentucky Viral Hepatitis Treatment Study

Jennifer Havens

NCT03949764

COMPLETED Phase 3 313 participants

Study to Assess Efficacy and Safety of BNX Sublingual Tablets for the Induction of Treatment of Opioid Dependence

Orexo AB

NCT01848054

COMPLETED NA 268 participants

Repeated-dose Behavioral Intervention to Reduce Opioid Overdose

San Francisco Department of Public Health

NCT03838510

COMPLETED NA 241 participants

Preventing Parental Opioid and/or Methamphetamine Addiction Within DHS-Involved Families: PRE-FAIR

Chestnut Health Systems

NCT05380440

COMPLETED Phase 3 208 participants

Open-Label Treatment Extension Study

Indivior

NCT02896296

COMPLETED NA 204 participants

Safety & Prevention Outcomes Study

University of Michigan

NCT01894087

COMPLETED Phase 2 202 participants

Buprenorphine Maintenance Dose Schedule and Treatment Setting - 1

National Institute on Drug Abuse (NIDA)

NCT00000318

COMPLETED Phase 2 142 participants

Treatment of Opioid/Heroin Dependence: Comparison of Three Medication Dosing Regimens

National Institute on Drug Abuse (NIDA)

NCT00218127

COMPLETED Phase 3 140 participants

Medication Treatment for Opioid Use Disorder in Expectant Mothers

T. John Winhusen, PhD

NCT03918850

COMPLETED Phase 2 115 participants

Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1

New York State Psychiatric Institute

NCT00061087

COMPLETED Phase 1 106 participants

Medications Development for Drug Abuse Disorders

Johns Hopkins University

NCT01188421

COMPLETED 97 participants

Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study

T. John Winhusen, PhD

NCT03911466

COMPLETED NA 88 participants

Substance Use Treatment and Recovery Team (START)

RAND

NCT04314648

COMPLETED 71 participants

Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study

T. John Winhusen, PhD

NCT03911739

COMPLETED NA 55 participants

Opioid Dependence Treatment Therapies in Pregnancy

University of Pittsburgh

NCT03098407

COMPLETED NA 53 participants

Transforming Opioid Prescribing in Primary Care

Boston Medical Center

NCT01909076

COMPLETED NA 48 participants

Bioequivalency Study of Buprenorphine Hydrochloride 8 mg Tablet Under Fasted Conditions

Roxane Laboratories

NCT00992095

COMPLETED Phase 2 44 participants

Abuse Potential of Intranasal VYCAVERT Tablets (Hydrocodone Bitartrate/Acetaminophen) in Recreational Opioid Users

Acura Pharmaceuticals

NCT01759446

COMPLETED 40 participants

Neurocognitive Effects of Buprenorphine Among HIV+ and HIV-Opioid Users

Albert Einstein College of Medicine

NCT01108679

COMPLETED Phase 2 38 participants

Induction of Opioid-Dependent Individuals Onto Buprenorphine and Buprenorphine/Naloxone

Indivior

NCT00637000

COMPLETED Phase 2 36 participants

Study of Computer-Based Treatment for Drug Dependence

Yale University

NCT01315184

COMPLETED Phase 3 18 participants

Buprenorphine Group Medical Visits in Primary Care

Montefiore Medical Center

NCT02526212

COMPLETED Phase 4 14 participants

Feasibility Study of Extended-release Naltrexone (Vivitrol) in Drug Court Settings

Duke University

NCT02978417

COMPLETED Phase 2 14 participants

Study to Evaluate the Subjective Effects of PTI-801 in Non-Physically Dependent Subjects With a History of Drug Abuse

Pain Therapeutics

NCT00734461

COMPLETED Phase 2 12 participants

Methylnaltrexone for Opioid-induced Constipation in Cancer Patients

University of Vermont

NCT01004393

COMPLETED Phase 2 12 participants

Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide - 2

University of Chicago

NCT00000250

COMPLETED NA 11 participants

Reinforcing Effects of Brief Exposures to Nitrous Oxide - 8

University of Chicago

NCT00000256

COMPLETED Phase 2 8 participants

A Laboratory Model for Heroin Abuse Medications - 8

New York State Psychiatric Institute

NCT00000273

COMPLETED Phase 2

Alternate-Day Buprenorphine Administration. Phase VII - 8

National Institute on Drug Abuse (NIDA)

NCT00000226

COMPLETED Phase 2

Alternate Day Buprenorphine Administration, Phase IX - 14

University of Vermont

NCT00000232

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 19
Phase 3 7
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Opioid-Related Disorders Trial Landscape

59 indexed Opioid-Related Disorders studies · 8 recruiting (14%).

Phase mix: 10 late (III/IV) vs 25 early (I/II).

Top sponsor: National Institute on Drug Abuse (NIDA) (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Opioid-Related Disorders?

PlainTrial tracks 59 US clinical trials for Opioid-Related Disorders, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Opioid-Related Disorders?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.