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Substance Abuse: early-phase trial registry
9 of 59 indexed Substance Abuse trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #241 of 28,707 conditions by registered trial count.
59 US clinical trials · 9 currently recruiting · #241 of 28,707 conditions by registered trial count
Substance Abuse: 59 US clinical trials tracked, 9 recruiting.
Substance Abuse is the subject of 59 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 6 of these trials.
Enrollment posture brief
Registry condition substance-abuse
OPEN 9 | RECR 15% | LATE 2 | EARLY 14 | RANK #241 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Arthroplasty, Replacement, Knee (15% recruiting · 13 trials)
Substance Abuse lists 9 open slots (15% of 59 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Substance Abuse on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Substance Abuse is recruiting below its size-band peers.
9 of 59 indexed trials (15.3%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Substance Abuse trials is spread across many organizations.
Yale University accounts for 6 of 59 trials (10.2%). 38 distinct sponsors appear on at least one study for this condition label.
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Typical Substance Abuse enrolment sits around 144 participants.
Median target enrolment is 144 among the 59 trials that report a genuine target (sentinel values excluded). 25 of those (42.4%) plan for fewer than 100 participants.
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Substance Abuse research is mostly interventional.
53 interventional and 6 observational studies make up this index (89.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
59 total, page 1 of 2
Substance Abuse Pre-Treatment Screening Study
The University of Texas Health Science Center, Houston
NCT00439049
SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families
Duke University
NCT06627764
Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention
Chestnut Health Systems
NCT06852170
Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts
Penn State University
NCT06856148
Harm Reduction Services
NYU Langone Health
NCT05776316
The STop UNhealthy Substance Use Now Trial
Ohio State University
NCT06524232
The Trans-Led Care Study
Illinois Institute of Technology
NCT06880705
Functional Connectivity Alterations in Suicidal Patients Among Opioid Users
Baylor College of Medicine
NCT05489042
Testing ALERT With GTO in Middle Schools
RAND
NCT05219422
The Community Youth Development Study: A Test of Communities That Care
University of Washington
NCT01088542
Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk
April M Young
NCT05657106
Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations
Yale University
NCT05286879
Continuing Care Following Drug Abuse Treatment: Linkage With Primary Care
Kaiser Permanente
NCT01621711
Nexalin Therapy as a Viable Adjunctive Treatment for Substance Use Disorders
University of Arizona
NCT03540745
Breathwork-assisted Treatment for Cannabis Use Disorder
Elias Dakwar
NCT05219825
A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements (CDEs) Into the Electronic Health Record (EHR) in Large Primary Care Settings ("CDE-EHR-PC" Study), Phase 3
NYU Langone Health
NCT02963948
Data-driven Identification for Substance Misuse
University of Wisconsin, Madison
NCT03833804
Physician Coaching to Reduce Opioid-related Harms
University of Wisconsin, Madison
NCT02433496
Integrated Care (iCare) at Mount Sinai to Improve Substance Use Diagnosis and Treatment Practices in HIV Clinic Settings
Icahn School of Medicine at Mount Sinai
NCT03092596
Personalized Health Assessment Related to Medications (Project PHARM)
University of Washington
NCT03037476
Fetal Alcohol Damage Prevention Study
Massachusetts General Hospital
NCT00696085
Master Mind Program Evaluation Study
Innovation Research & Training
NCT03212066
Web-delivery of Evidence-based, Psychosocial Treatment for Substance Use Disorders
New York State Psychiatric Institute
NCT01104805
Enhancing Prevention Capacity With Developmental Assets and Getting to Outcomes
RAND
NCT00780338
Contingency Management for Smoking in Substance Abusers
Brown University
NCT00807742
Building Outcomes With Observation-Based Supervision: An FFT Effectiveness Trial
Oregon Research Institute
NCT01614015
Teen Success Project
Chestnut Health Systems
NCT03015805
Evaluation of Treatments for Homeless Youths
Ohio State University
NCT01143792
Family Listening Program: Multi-Tribal Implementation and Evaluation
University of New Mexi
NCT03142009
Youth Substance Use Prevention/Reduction Through Science-based Drug Abuse Education
Boston Children's Hospital
NCT00612482
Family-Based Treatment for Parental Substance Abuse and Child Maltreatment
Medical University of South Carolina
NCT01656837
Adolescent Involvement in Parental Substance Abuse Treatment
Ohio State University
NCT01576393
Computer Based Training in Cognitive Behavioral Therapy Web-based
Yale University
NCT01442597
OPTIONS: A Patient-Centered HIV Prevention Decision Aid for PrEP Uptake for Women With Substance Use in Treatment Settings
Yale University
NCT03651453
An Evaluation of JUST Court in Yuma County, AZ
Pepperdine University
NCT02449057
The Men's Domestic Abuse Check-Up Engages Adult Men Concerned About Their Abusive Behavior and Alcohol or Drug Use
University of Washington
NCT01621334
Medication Treatment for Opioid Use Disorder in Expectant Mothers
T. John Winhusen, PhD
NCT03918850
Juvenile Offender HIV Prevention and Drug Abuse Services
University of Miami
NCT01922297
Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study
T. John Winhusen, PhD
NCT03911466
CARESS: An Investigation of Effects of CARESS
Inova Health Care Services
NCT03758027
Aripiprazole Treatment for Methamphetamine Dependence Among High-risk Individuals
San Francisco Department of Public Health
NCT00497055
To Reach Unrestricted Services for Transgender Women
University of Central Florida
NCT03877497
Substance Abuse Treatment for High Risk Chronic Pain Patients on Opioid Therapy
Brigham and Women's Hospital
NCT00988962
Study of Medical Treatment for Methamphetamine Addiction
University of California, Los Angeles
NCT00833443
Computer-Assisted Brief Intervention
Brown University
NCT03107117
Rivastigmine and Huperzine A as Treatments for Cocaine Dependence
Baylor College of Medicine
NCT01030692
Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study
T. John Winhusen, PhD
NCT03911739
Atomoxetine for Attention Deficit Hyperactivity Disorder in Adolescents With Substance Use Disorder
Denver Health and Hospital Authority
NCT00399763
An Integrated Substance Abuse-Domestic Violence (SADV) Treatment Outcome Study
Yale University
NCT07140276
Substance Treatment and HIV Testing and Referral System
Polaris Health Directions
NCT01488630
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 8 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Substance Abuse records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Substance Abuse trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Substance Abuse page
59 registered trials, 9 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 9 Substance Abuse trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Yale University sponsors the most Substance Abuse trials on record, review their full trial history before evaluating a specific study. See Yale University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Substance Abuse condition card totals 59 registered trials; most-linked intervention Placebo; top US site state Connecticut. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.