Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Substance Abuse
Open-data reference.
59 US clinical trials · 9 currently recruiting
Active & Recent Trials
Substance Abuse Pre-Treatment Screening Study
The University of Texas Health Science Center, Houston
NCT00439049
SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families
Duke University
NCT06627764
Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention
Chestnut Health Systems
NCT06852170
Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts
Penn State University
NCT06856148
Harm Reduction Services
NYU Langone Health
NCT05776316
The STop UNhealthy Substance Use Now Trial
Ohio State University
NCT06524232
The Trans-Led Care Study
Illinois Institute of Technology
NCT06880705
Functional Connectivity Alterations in Suicidal Patients Among Opioid Users
Baylor College of Medicine
NCT05489042
Testing ALERT With GTO in Middle Schools
RAND
NCT05219422
The Community Youth Development Study: A Test of Communities That Care
University of Washington
NCT01088542
Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk
April M Young
NCT05657106
Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations
Yale University
NCT05286879
Continuing Care Following Drug Abuse Treatment: Linkage With Primary Care
Kaiser Permanente
NCT01621711
Nexalin Therapy as a Viable Adjunctive Treatment for Substance Use Disorders
University of Arizona
NCT03540745
Breathwork-assisted Treatment for Cannabis Use Disorder
Elias Dakwar
NCT05219825
A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements (CDEs) Into the Electronic Health Record (EHR) in Large Primary Care Settings ("CDE-EHR-PC" Study), Phase 3
NYU Langone Health
NCT02963948
Data-driven Identification for Substance Misuse
University of Wisconsin, Madison
NCT03833804
Physician Coaching to Reduce Opioid-related Harms
University of Wisconsin, Madison
NCT02433496
Integrated Care (iCare) at Mount Sinai to Improve Substance Use Diagnosis and Treatment Practices in HIV Clinic Settings
Icahn School of Medicine at Mount Sinai
NCT03092596
Personalized Health Assessment Related to Medications (Project PHARM)
University of Washington
NCT03037476
Fetal Alcohol Damage Prevention Study
Massachusetts General Hospital
NCT00696085
Master Mind Program Evaluation Study
Innovation Research & Training
NCT03212066
Web-delivery of Evidence-based, Psychosocial Treatment for Substance Use Disorders
New York State Psychiatric Institute
NCT01104805
Enhancing Prevention Capacity With Developmental Assets and Getting to Outcomes
RAND
NCT00780338
Contingency Management for Smoking in Substance Abusers
Brown University
NCT00807742
Building Outcomes With Observation-Based Supervision: An FFT Effectiveness Trial
Oregon Research Institute
NCT01614015
Teen Success Project
Chestnut Health Systems
NCT03015805
Evaluation of Treatments for Homeless Youths
Ohio State University
NCT01143792
Family Listening Program: Multi-Tribal Implementation and Evaluation
University of New Mexi
NCT03142009
Youth Substance Use Prevention/Reduction Through Science-based Drug Abuse Education
Boston Children's Hospital
NCT00612482
Family-Based Treatment for Parental Substance Abuse and Child Maltreatment
Medical University of South Carolina
NCT01656837
Adolescent Involvement in Parental Substance Abuse Treatment
Ohio State University
NCT01576393
Computer Based Training in Cognitive Behavioral Therapy Web-based
Yale University
NCT01442597
OPTIONS: A Patient-Centered HIV Prevention Decision Aid for PrEP Uptake for Women With Substance Use in Treatment Settings
Yale University
NCT03651453
An Evaluation of JUST Court in Yuma County, AZ
Pepperdine University
NCT02449057
The Men's Domestic Abuse Check-Up Engages Adult Men Concerned About Their Abusive Behavior and Alcohol or Drug Use
University of Washington
NCT01621334
Medication Treatment for Opioid Use Disorder in Expectant Mothers
T. John Winhusen, PhD
NCT03918850
Juvenile Offender HIV Prevention and Drug Abuse Services
University of Miami
NCT01922297
Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study
T. John Winhusen, PhD
NCT03911466
CARESS: An Investigation of Effects of CARESS
Inova Health Care Services
NCT03758027
Aripiprazole Treatment for Methamphetamine Dependence Among High-risk Individuals
San Francisco Department of Public Health
NCT00497055
To Reach Unrestricted Services for Transgender Women
University of Central Florida
NCT03877497
Substance Abuse Treatment for High Risk Chronic Pain Patients on Opioid Therapy
Brigham and Women's Hospital
NCT00988962
Study of Medical Treatment for Methamphetamine Addiction
University of California, Los Angeles
NCT00833443
Computer-Assisted Brief Intervention
Brown University
NCT03107117
Rivastigmine and Huperzine A as Treatments for Cocaine Dependence
Baylor College of Medicine
NCT01030692
Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study
T. John Winhusen, PhD
NCT03911739
Atomoxetine for Attention Deficit Hyperactivity Disorder in Adolescents With Substance Use Disorder
Denver Health and Hospital Authority
NCT00399763
An Integrated Substance Abuse-Domestic Violence (SADV) Treatment Outcome Study
Yale University
NCT07140276
Substance Treatment and HIV Testing and Referral System
Polaris Health Directions
NCT01488630
Integration of Buprenorphine Into HIV Clinical Settings - Primary Care Model (PCM)
Yale University
NCT00798538
Computer Based Training in CBT in Primary Care
Yale University
NCT03013478
Evaluation of Atomoxetine for Cocaine Dependence: A Pilot Trial
Sharon Walsh
NCT00617201
Group Therapy for Women Prisoners With Comorbid Substance Use and Depression
Brown University
NCT00606996
Neuromodulation to Facilitate the Effect of Ketamine
The Neuroscience Center
NCT01816958
Improving Antihypertensive Medication Adherence
UConn Health
NCT01296594
Exercise as a Behavioral Treatment for Cocaine Dependence
Baylor College of Medicine
NCT01601743
Varenicline vs Placebo for the Treatment of Methamphetamine Dependence
University of California, Los Angeles
NCT01011829
Safety Interaction Trial Ibudilast and Methamphetamine
University of California, Los Angeles
NCT01217970
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 6 |
| Phase 2 | 8 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Substance Abuse Trial Landscape
ClinicalTrials.gov lists 59 US studies indexed under Substance Abuse, and 9 of those are currently open to recruitment — roughly 15% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Substance Abuse shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 14 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Substance Abuse is led by Yale University with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 59 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Substance Abuse?
PlainTrial tracks 59 US clinical trials for Substance Abuse, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Substance Abuse?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.