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NCT06810076 · ClinicalTrials.gov registry record · NA
Developing and Evaluating a Machine-Learning Opioid Overdose Prediction & Risk-Stratification Tool in Primary Care
A NA study of Substance-Related Disorders and Opioid-Related Disorders, sponsored by University of Pittsburgh.
- Recruiting
- Registry status
- NA
- Development phase
- 2,000
- Enrollment target
- 1
- Study location
NCT06810076: Recruiting NA study of Substance-Related Disorders and Opioid-Related Disorders, sponsored by University of Pittsburgh.
NCT06810076 is a NA study of Substance-Related Disorders and Opioid-Related Disorders that is actively recruiting participants, run by University of Pittsburgh. The registered enrollment target is 2,000 participants, above the 1,487-participant average among 58 other Substance-Related Disorders trials with a reported enrollment target (34% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06810076, a NA study of Substance-Related Disorders and Opioid-Related Disorders, is actively recruiting participants, sponsored by University of Pittsburgh.
- RECRUITING
- Registry status
- NA
- Development phase
- 2,000 participants
- Enrollment target
- 1
- Study location
Study Summary
This clinical trial aims to evaluate the pilot implementation of a machine-learning (ML)-driven clinical decision support (CDS) tool designed to predict opioid overdose risk within the electronic health record (EHR) system at UF Health Internal Medicine and Family Medicine clinics in Gainesville, Florida. The study will use a pre- versus post-implementation design to compare outcomes within clinics, focusing on measures such as naloxone prescribing rates and opioid overdose occurrences. Researchers will also assess the usability, acceptability, and feasibility of the CDS tool through qualitative interviews with primary care clinicians (PCPs) in the participating clinics.
Primary Outcome
The CDS tool will generate an Overdose Prevention Alert (OPA) when a PCP signs an opioid order in Epic®. To evaluate the tool's effectiveness, researchers will conduct within-clinic comparisons (pre- vs. post-implementation) and examine a composite of patient-level outcomes post-implementation, including the proportion of patients having any of the following 6 outcomes: 1. receipt of a naloxone order or prescription fill; 2. absence of opioid overdose diagnoses and naloxone administration; 3. a
Conditions Studied
Interventions
- BEHAVIORAL Machine Learning-Based Clinical Decision Support: Overdose Prevention Alert (OPA) Intervention
Study Locations (1)
Florida
- University of Florida Health Internal Medicine and Family Medicine - Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,000 participants |
| Start Date | 2025-04-08 |
| Est. Completion | 2026-10-02 |
| Phase | NA |
What NCT06810076 shows while recruiting
NCT06810076 is an interventional study that assigns participants to a tested intervention. Its 2,000 participants enrollment target places it among the larger protocols in the corpus, above the 1,487-participant average among 58 other Substance-Related Disorders trials with a reported enrollment target (34% higher).
The record links to 6 conditions, with Substance-Related Disorders appearing as the primary indexed condition, and to 1 intervention - of which Machine Learning-Based Clinical Decision Support: Overdose Prevention Alert (OPA) Intervention is the first listed.
NCT06810076 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT06810076 about?
NCT06810076 is a clinical study titled "Developing and Evaluating a Machine-Learning Opioid Overdose Prediction & Risk-Stratification Tool in Primary Care". This clinical trial aims to evaluate the pilot implementation of a machine-learning (ML)-driven clinical decision support (CDS) tool designed to predict opioid overdose risk within the electronic health record (EHR) system at UF Health Internal Medicine and Family Medicine clinics in Gainesville, Fl...
What is the current status of trial NCT06810076?
This trial is currently recruiting. It is a NA study. The enrollment target is 2,000 participants. The study started on 2025-04-08. Estimated completion is 2026-10-02.
What conditions does trial NCT06810076 study?
This clinical trial studies the following conditions: Substance-Related Disorders, Opioid-Related Disorders, Mental Disorders, Narcotic-Related Disorders, Chemically-Induced Disorders.
What interventions are being tested in trial NCT06810076?
The interventions under investigation include: Machine Learning-Based Clinical Decision Support: Overdose Prevention Alert (OPA) Intervention (BEHAVIORAL).
Who is sponsoring clinical trial NCT06810076?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06810076 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06810076's enrollment target sits among peer trials
2,000 3rd of 58 higher than 56 of 58 other Substance-Related Disorders trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Substance-Related Disorders trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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