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Opioid Dependence clinical trials
8 of 30 indexed Opioid Dependence trials are currently recruiting.
30 US clinical trials · 8 currently recruiting
Opioid Dependence is the subject of 30 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is New York State Psychiatric Institute, running 4 of these trials.
The research picture
Opioid Dependence has 30 registered US clinical trials, 8 of them open to new participants right now, about 27% of the total.
- 8
- recruiting participants now
- 27%
- of trials open to enrollment
- 9
- in Phase 3–4 (later-stage)
- 4
- top sponsor: New York State Psychiatric Institute
Active & Recent Trials
30 total, page 1 of 1
Better Options for Chronic Cancer Pain
VA Office of Research and Development
NCT06574009
Young Houston Emergency Opioid Engagement System
The University of Texas Health Science Center, Houston
NCT04811014
fMRI and Opioid Abstinence
Yale University
NCT06651333
Intervening With Opioid-Dependent MothersMothers and Infants
University of Delaware
NCT04454645
Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery
Jenna-Leigh Wilson
NCT06949826
The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care
Oregon Health and Science University
NCT06837662
Neuromodulation and Cognitive Training in Opioid Use Disorder
University of Minnesota
NCT03773523
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
Indiana University
NCT05603702
Comparing Home, Office, and Telehealth Induction for Medication Assisted Treatment for Opioid Use Disorder
University of Colorado, Denver
NCT04664062
Facilitating Rapid Naltrexone Initiation
New York State Psychiatric Institute
NCT03345173
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
Northwestern University
NCT05463367
Treatment Seeking Participants With Opioid Use Disorders Assessing Tolerability of Depot Injections of Buprenorphine
Indivior
NCT02357901
Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14
National Institute on Drug Abuse (NIDA)
NCT00015340
ALK21-025: Vivitrol's Cost and Treatment Outcomes Registry
Alkermes
NCT01422837
Comparing Interventions for Opioid Dependent Patients Presenting in Medical Emergency Departments
NYU Langone Health
NCT02586896
Improved Strategies for Outpatient Opioid Detoxification
New York State Psychiatric Institute
NCT01377610
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1
National Institute on Drug Abuse (NIDA)
NCT00158288
Improving Effective Contraceptive Use Among Opioid-maintained Women: Stage II
University of Vermont
NCT02411357
PG and PK of Oxycodone to Personalize Post-op Pain Management Following Surgery in Children
Senthil Sadhasivam
NCT03495388
Medications Development for Drug Abuse Disorders
Johns Hopkins University
NCT01188421
Memantine-enhanced Buprenorphine Treatment for Opioid-dependent Young Adults
University of Massachusetts, Worcester
NCT01052662
Aprepitant Effects in Intravenous Heroin Dependence
NYU Langone Health
NCT01527994
Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures
Denver Health and Hospital Authority
NCT03305666
Usability of Zubsolv Sublingual Tablets 5.7/1.4 to Suboxone Sublingual Film 8/2 In Buprenorphine/Naloxone Treated Opioid Dependent Population
Indivior
NCT02038790
Effects of Ibudilast on Oxycodone Self-administration in Opioid Abusers
New York State Psychiatric Institute
NCT01740414
Remote Observed Dosing of Suboxone to Improve Clinical Practice
University of Pennsylvania
NCT03769025
Treatment for Opioid Dependent Offenders
University of Wisconsin, Madison
NCT01082679
Medication-Assisted Treatment for Youth With Substance Use Disorders
New York State Psychiatric Institute
NCT02593474
Using mHealth to Aid Opioid Medication Adherence Pilot Study
Care Team Solutions
NCT02017041
Buprenorphine Treatment for Opioid Dependence
Yale University
NCT02187198
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 5 |
| Phase 3 | 3 |
| Phase 4 | 6 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Opioid Dependence Trial Landscape
30 indexed Opioid Dependence studies · 8 recruiting (27%).
Phase mix: 9 late (III/IV) vs 11 early (I/II).
Top sponsor: New York State Psychiatric Institute (4 trials), 9 others listed. 30 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Opioid Dependence?
PlainTrial tracks 30 US clinical trials for Opioid Dependence, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Opioid Dependence?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.