Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Opioid Dependence: full-pipeline trial registry
8 of 30 indexed Opioid Dependence trials are currently recruiting.
Corpus placement: #519 of 28,707 conditions by registered trial count.
30 US clinical trials · 8 currently recruiting · #519 of 28,707 conditions by registered trial count
Opioid Dependence: 30 US clinical trials tracked, 8 recruiting.
Opioid Dependence is the subject of 30 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is New York State Psychiatric Institute, running 4 of these trials.
Enrollment posture brief
Registry condition opioid-dependence
OPEN 8 | RECR 27% | LATE 9 | EARLY 11 | RANK #519 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Age-related Macular Degeneration (27% recruiting · 75 trials)
Opioid Dependence lists 8 open slots (27% of 30 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Opioid Dependence on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Opioid Dependence is recruiting below its size-band peers.
8 of 30 indexed trials (26.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Opioid Dependence trials is spread across many organizations.
New York State Psychiatric Institute accounts for 4 of 30 trials (13.3%). 23 distinct sponsors appear on at least one study for this condition label.
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Typical Opioid Dependence enrolment sits around 100 participants.
Median target enrolment is 100 among the 30 trials that report a genuine target (sentinel values excluded). 14 of those (46.7%) plan for fewer than 100 participants.
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Opioid Dependence research is mostly interventional.
26 interventional and 4 observational studies make up this index (86.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
30 total, page 1 of 1
Better Options for Chronic Cancer Pain
VA Office of Research and Development
NCT06574009
Young Houston Emergency Opioid Engagement System
The University of Texas Health Science Center, Houston
NCT04811014
fMRI and Opioid Abstinence
Yale University
NCT06651333
Intervening With Opioid-Dependent MothersMothers and Infants
University of Delaware
NCT04454645
Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery
Jenna-Leigh Wilson
NCT06949826
The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care
Oregon Health and Science University
NCT06837662
Neuromodulation and Cognitive Training in Opioid Use Disorder
University of Minnesota
NCT03773523
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
Indiana University
NCT05603702
Comparing Home, Office, and Telehealth Induction for Medication Assisted Treatment for Opioid Use Disorder
University of Colorado, Denver
NCT04664062
Facilitating Rapid Naltrexone Initiation
New York State Psychiatric Institute
NCT03345173
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
Northwestern University
NCT05463367
Treatment Seeking Participants With Opioid Use Disorders Assessing Tolerability of Depot Injections of Buprenorphine
Indivior
NCT02357901
Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14
National Institute on Drug Abuse (NIDA)
NCT00015340
ALK21-025: Vivitrol's Cost and Treatment Outcomes Registry
Alkermes
NCT01422837
Comparing Interventions for Opioid Dependent Patients Presenting in Medical Emergency Departments
NYU Langone Health
NCT02586896
Improved Strategies for Outpatient Opioid Detoxification
New York State Psychiatric Institute
NCT01377610
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1
National Institute on Drug Abuse (NIDA)
NCT00158288
Improving Effective Contraceptive Use Among Opioid-maintained Women: Stage II
University of Vermont
NCT02411357
PG and PK of Oxycodone to Personalize Post-op Pain Management Following Surgery in Children
Senthil Sadhasivam
NCT03495388
Medications Development for Drug Abuse Disorders
Johns Hopkins University
NCT01188421
Memantine-enhanced Buprenorphine Treatment for Opioid-dependent Young Adults
University of Massachusetts, Worcester
NCT01052662
Aprepitant Effects in Intravenous Heroin Dependence
NYU Langone Health
NCT01527994
Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures
Denver Health and Hospital Authority
NCT03305666
Usability of Zubsolv Sublingual Tablets 5.7/1.4 to Suboxone Sublingual Film 8/2 In Buprenorphine/Naloxone Treated Opioid Dependent Population
Indivior
NCT02038790
Effects of Ibudilast on Oxycodone Self-administration in Opioid Abusers
New York State Psychiatric Institute
NCT01740414
Remote Observed Dosing of Suboxone to Improve Clinical Practice
University of Pennsylvania
NCT03769025
Treatment for Opioid Dependent Offenders
University of Wisconsin, Madison
NCT01082679
Medication-Assisted Treatment for Youth With Substance Use Disorders
New York State Psychiatric Institute
NCT02593474
Using mHealth to Aid Opioid Medication Adherence Pilot Study
Care Team Solutions
NCT02017041
Buprenorphine Treatment for Opioid Dependence
Yale University
NCT02187198
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 5 |
| Phase 3 | 3 |
| Phase 4 | 6 |
Top Sponsors
Named interventions
Most-linked intervention names on Opioid Dependence records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Opioid Dependence trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Opioid Dependence page
30 registered trials, 8 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 8 Opioid Dependence trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- New York State Psychiatric Institute sponsors the most Opioid Dependence trials on record, review their full trial history before evaluating a specific study. See New York State Psychiatric Institute's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Opioid Dependence condition card totals 30 registered trials; most-linked intervention Buprenorphine/naloxone; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.