Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Non-small Cell Lung Cancer (NSCLC)

Open-data reference.

29 US clinical trials · 20 currently recruiting

Active & Recent Trials

RECRUITING Phase 1 1,314 participants

Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

Exelixis

NCT05176483

RECRUITING Phase 1 754 participants

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

Revolution Medicines

NCT05379985

RECRUITING Phase 3 614 participants

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

Merck Sharp & Dohme

NCT06170788

RECRUITING Phase 1 604 participants

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Revolution Medicines

NCT06040541

RECRUITING Phase 1 574 participants

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

Revolution Medicines

NCT07349537

RECRUITING Phase 3 556 participants

Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)

Merck Sharp & Dohme

NCT06074588

RECRUITING Phase 3 520 participants

Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)

Merck Sharp & Dohme

NCT06305754

RECRUITING Phase 3 400 participants

Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

AstraZeneca

NCT07291037

RECRUITING Phase 1 370 participants

Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

Revolution Medicines

NCT07397338

RECRUITING Phase 1 345 participants

A Study of NX-1607 in Adults With Advanced Malignancies

Nurix Therapeutics

NCT05107674

RECRUITING Phase 1 252 participants

A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies

Bristol-Myers Squibb

NCT07223047

RECRUITING Phase 1 240 participants

A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.

Bristol-Myers Squibb

NCT06476808

RECRUITING Phase 2 240 participants

Study to Assess the Efficacy and Safety of Rina-S in Participants With Non-small Cell Lung Cancer

Genmab

NCT07288177

RECRUITING Phase 1 230 participants

Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors

Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals

NCT05985655

RECRUITING Phase 3 180 participants

Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)

Nuvation Bio

NCT07154706

RECRUITING Phase 1 171 participants

Study of FIH of STX-241 in Locally Advanced or Metastatic NSCLC Resistant to EGFR TKIs

Pierre Fabre Medicament

NCT06567015

RECRUITING Phase 1 40 participants

A Study of Gilteritinib in Adults With Advanced ALK-positive Non-small Cell Lung Cancer (NSCLC)

Astellas Pharma Global Development

NCT07140016

RECRUITING Phase 1 30 participants

Study of the Immune Response of MUC1 (Mucin1) Peptide Vaccine for Non-small Cell Lung Cancer

Olivera Finn

NCT01720836

RECRUITING Phase 1 27 participants

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

Tanabe Pharma America

NCT06943521

RECRUITING Phase 1 9 participants

Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer or Other Solid Tumors

Radiopharm Theranostics

NCT05799274

ACTIVE NOT RECRUITING 300 participants

Long-Term Safety Outcomes and First-Line Treatment Patterns in Patients With Non-Small Cell Lung Cancer and Programmed Death-1 (Pd-L1) <1%

Bristol-Myers Squibb

NCT07215962

ACTIVE NOT RECRUITING Phase 1 209 participants

A Phase 1/2a Study of IMM-1-104 in Participants With Advanced or Metastatic Solid Tumors

Immuneering Corporation

NCT05585320

ACTIVE NOT RECRUITING Phase 1 100 participants

Phase 1b/2 Platform Study of Select Immunotherapy Combinations in Participants With Advanced Non-small Cell Lung Cancer (NSCLC)

Servier Bio-Innovation

NCT06162572

ACTIVE NOT RECRUITING Phase 1 65 participants

An Efficacy and Safety Study of Cofetuzumab Pelidotin in Participants With PTK7-Expressing, Recurrent Non-Small Cell Lung Cancer

AbbVie

NCT04189614

ACTIVE NOT RECRUITING Phase 2 60 participants

PCSK9 Inhibitor and PD-1 Inhibitor in Patients With Metastatic, Refractory To Prior Anti PD-1 Non-small Cell Lung

Duke University

NCT05553834

ACTIVE NOT RECRUITING Phase 2 41 participants

Study of Osimertinib and Stereotactic Ablative Radiation (SABR) in EGFR Mutant NSCLC

University of Texas Southwestern Medical Center

NCT03667820

COMPLETED Phase 2 48 participants

Phase II Bevacizumab, Gemcitabine and Carboplatin in Newly Diagnosed Non-Small Cell Lung Cancer

Stanford University

NCT00323869

COMPLETED Phase 1 24 participants

A Trial of CV301 in Combination With Anti-PD-1 Therapy in Subjects With Non-Small Cell Lung Cancer

Bavarian Nordic

NCT02840994

COMPLETED Phase 1 5 participants

Feasibility Study of Using Navigational Bronchoscopy to Perform PDT-Photofrin® in Unresectable Peripheral Lung Cancer

Concordia Laboratories

NCT02916745

Phase Distribution

PhaseTrial count
Early Phase 1 19
Phase 2 4
Phase 3 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Non-small Cell Lung Cancer (NSCLC) Trial Landscape

ClinicalTrials.gov lists 29 US studies indexed under Non-small Cell Lung Cancer (NSCLC), and 20 of those are currently open to recruitment — roughly 69% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Non-small Cell Lung Cancer (NSCLC) shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 23 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Non-small Cell Lung Cancer (NSCLC) is led by Revolution Medicines with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 29 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Non-small Cell Lung Cancer (NSCLC)?

PlainTrial tracks 29 US clinical trials for Non-small Cell Lung Cancer (NSCLC), of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Non-small Cell Lung Cancer (NSCLC)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →