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NCT06332755 · ClinicalTrials.gov registry record · Phase 1
Study to Evaluate LB-LR1109, Administered Alone for the Treatment of Solid Tumor and in Combination With Atezolizumab for the Treatment of NSCLC
A Phase 1 study of Urothelial Carcinoma and Non-small Cell Lung Cancer (NSCLC), sponsored by LG Chem.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 76
- Enrollment target
- 1
- Study location
NCT06332755: Recruiting Phase 1 study of Urothelial Carcinoma and Non-small Cell Lung Cancer (NSCLC), sponsored by LG Chem.
NCT06332755 is a Phase 1 study of Urothelial Carcinoma and Non-small Cell Lung Cancer (NSCLC) that is actively recruiting participants, run by LG Chem. The registered enrollment target is 76 participants, below the 238-participant average among 85 other Urothelial Carcinoma trials with a reported enrollment target (68% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06332755, a Phase 1 study of Urothelial Carcinoma and Non-small Cell Lung Cancer (NSCLC), is actively recruiting participants, sponsored by LG Chem.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 76 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a Phase 1a/1b, first-in-human (FIH), multi-center, open-label, non-randomized, dose escalation study, designed to determine the Maximum tolerated dose(MTD)/Recommended Phase 2 dose (RP2D) and to evaluate safety, tolerability, preliminary efficacy, pharmacokinetics, immunogenicity, pharmacodynamics of LB-LR1109 as monotherapy in participants with advanced and/or metastatic non small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), renal cell carcinoma (RCC), urothelial carcinoma, or malignant melanoma and no available standard of care treatment options, and as combination therapy with atezolizumab in participants with advanced and/or metastatic NSCLC.
Primary Outcome
Number of participants with dose-limiting toxicities (DLTs)
Conditions Studied
Interventions
- DRUG Phase 1a: LB-LR1109
- DRUG Phase 1b: LB-LR1109 and Atezolizumab
Study Locations (1)
Virginia
- NEXT Oncology - Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 76 participants |
| Start Date | 2024-06-05 |
| Est. Completion | 2028-03 |
| Phase | Phase 1 |
What NCT06332755 shows while recruiting
NCT06332755 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 76 participants, a relatively small participant target, below the 238-participant average among 85 other Urothelial Carcinoma trials with a reported enrollment target (68% lower).
The record links to 5 conditions, with Urothelial Carcinoma appearing as the primary indexed condition, and to 2 interventions - of which Phase 1a: LB-LR1109 is the first listed.
NCT06332755 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT06332755 about?
NCT06332755 is a clinical study titled "Study to Evaluate LB-LR1109, Administered Alone for the Treatment of Solid Tumor and in Combination With Atezolizumab for the Treatment of NSCLC". This is a Phase 1a/1b, first-in-human (FIH), multi-center, open-label, non-randomized, dose escalation study, designed to determine the Maximum tolerated dose(MTD)/Recommended Phase 2 dose (RP2D) and to evaluate safety, tolerability, preliminary efficacy, pharmacokinetics, immunogenicity, pharmacody...
What is the current status of trial NCT06332755?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 76 participants. The study started on 2024-06-05. Estimated completion is 2028-03.
What conditions does trial NCT06332755 study?
This clinical trial studies the following conditions: Urothelial Carcinoma, Non-small Cell Lung Cancer (NSCLC), Malignant Melanoma, Head and Neck Squamous Cell Carcinoma (HNSCC), Renal Cell Carcinoma (RCC).
What interventions are being tested in trial NCT06332755?
The interventions under investigation include: Phase 1a: LB-LR1109 (DRUG), Phase 1b: LB-LR1109 and Atezolizumab (DRUG).
Who is sponsoring clinical trial NCT06332755?
This trial is sponsored by LG Chem, which has 13 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06332755 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06332755's enrollment target sits among peer trials
76 42nd of 85 higher than 44 of 85 other Urothelial Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Urothelial Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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