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NCT07154706 · ClinicalTrials.gov registry record · Phase 3
Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)
A Phase 3 study of Non-small Cell Lung Cancer (NSCLC), sponsored by Nuvation Bio.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 180
- Enrollment target
- 10
- Study locations
NCT07154706 is a Phase 3 study of Non-small Cell Lung Cancer (NSCLC) that is actively recruiting participants, run by Nuvation Bio. The registered enrollment target is 180 participants, below the 286-participant average among 58 other Non-small Cell Lung Cancer (NSCLC) trials with a reported enrollment target (37% lower). The trial reports 10 study locations across 9 states.
The verdict
NCT07154706, a Phase 3 study of Non-small Cell Lung Cancer (NSCLC), is actively recruiting participants, sponsored by Nuvation Bio.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 180 participants
- Enrollment target
- 10
- Study locations
Study Summary
The purpose of this phase 3 multicenter double-blind randomized study is to assess the use of taletrectinib in the early-stage non-small cell lung cancer (NSCLC). The study compares taletrectinib (study drug) versus placebo (sugar pill) in patients with ROS1-fusion positive stage IB, II, IIIA NSCLC. The study will evaluate if taletrectinib is better than placebo at preventing the participant's disease from coming back after the participant's lung tumor was removed.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Taletrectinib
Study Locations (10)
Texas
- Sarah Cannon Research Institute (SCRI) - Texas Oncology-Central South - Austin
- MD Anderson - Houston
California
- UCLA - Los Angeles
District of Columbia
- Georgetown University Medical Cener (GUMC) - Washington D.C.
Idaho
- Saint Alphonsus Health System - Boise
Massachusetts
- Dana Farber Cancer Institute - Boston
Minnesota
- Mayo Clinic - Rochester
New York
- Memorial Sloan Kettering Cancer Center - New York
Virginia
- Virginia Cancer Specialists - Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2025-08-21 |
| Est. Completion | 2033-08-30 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07154706
The ClinicalTrials.gov registry entry for NCT07154706 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 286-participant average among 58 other Non-small Cell Lung Cancer (NSCLC) trials with a reported enrollment target (37% lower). The listed sponsor is Nuvation Bio, which has 7 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Non-small Cell Lung Cancer (NSCLC) appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT07154706 reports 10 study locations spanning 9 distinct geographic areas - top geographies include Texas, California, District of Columbia.
Frequently Asked Questions
What is clinical trial NCT07154706 about?
NCT07154706 is a clinical study titled "Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)". The purpose of this phase 3 multicenter double-blind randomized study is to assess the use of taletrectinib in the early-stage non-small cell lung cancer (NSCLC). The study compares taletrectinib (study drug) versus placebo (sugar pill) in patients with ROS1-fusion positive stage IB, II, IIIA NSCLC....
What is the current status of trial NCT07154706?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 180 participants. The study started on 2025-08-21. Estimated completion is 2033-08-30.
What conditions does trial NCT07154706 study?
This clinical trial studies the following conditions: Non-small Cell Lung Cancer (NSCLC).
What interventions are being tested in trial NCT07154706?
The interventions under investigation include: Placebo (DRUG), Taletrectinib (DRUG).
Who is sponsoring clinical trial NCT07154706?
This trial is sponsored by Nuvation Bio, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07154706 being conducted?
This trial has 10 study locations across California, District of Columbia, Idaho, Massachusetts, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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