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ClinicalTrials.gov 15 recruiting now official registry

Non-muscle Invasive Bladder Cancer clinical trials

15 of 29 indexed Non-muscle Invasive Bladder Cancer trials are currently recruiting.

29 US clinical trials · 15 currently recruiting

Non-muscle Invasive Bladder Cancer is the subject of 29 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is CG Oncology, running 2 of these trials.

The research picture

Non-muscle Invasive Bladder Cancer has 29 registered US clinical trials, 15 of them open to new participants right now, about 52% of the total.

15
recruiting participants now
52%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
2
top sponsor: CG Oncology
Phase 112Phase 25Phase 36

Active & Recent Trials

29 total, page 1 of 1

RECRUITING 600 participants

Artificial Intelligence Prediction Tool in Non-muscle Invasive Bladder Cancer (NMIBC)

University of Texas Southwestern Medical Center

NCT05825950

RECRUITING Phase 1 596 participants

A Study of Intravesical BCG in Combination With ALT-803 in Patients With Non-Muscle Invasive Bladder Cancer

ImmunityBio

NCT02138734

RECRUITING Phase 1 294 participants

A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer

Pfizer

NCT07206225

RECRUITING Phase 2 240 participants

Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

White River Junction Veterans Affairs Medical Center

NCT05796375

RECRUITING Phase 2 166 participants

Trial of Encapsulated Rapamycin (eRapa) for Bladder Cancer Prevention

Robert Svatek

NCT04375813

RECRUITING Phase 2 131 participants

Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer

Protara Therapeutics

NCT05951179

RECRUITING Phase 3 125 participants

A Study Comparing Standard Treatments in People With Non-Muscle Invasive Bladder Cancer (NMIBC)

Memorial Sloan Kettering Cancer Center

NCT06929286

RECRUITING Phase 1 75 participants

A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer

SURGE Therapeutics

NCT05710848

RECRUITING Phase 2 60 participants

A Trial of Durvalumab (MEDI4736) Plus Monalizumab in Non-Muscle-Invasive Bladder Cancer

John Sfakianos

NCT06503614

RECRUITING Phase 1 55 participants

Study of 2141-V11 in People With Non-muscle Invasive Bladder Cancer That Did Not Respond to Standard Treatment

Memorial Sloan Kettering Cancer Center

NCT05126472

RECRUITING Phase 1 55 participants

A Phase 1, Open-label Trial of Belzupacap Sarotalocan (AU-011) in Bladder Cancer

Aura Biosciences

NCT05483868

RECRUITING 42 participants

Mood Alterations in the Patients With Non-Muscle Invasive Bladder Cancer Treated With BCG

Johns Hopkins University

NCT05672615

RECRUITING Phase 1 32 participants

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)

Merck Sharp & Dohme

NCT06637423

RECRUITING NA 30 participants

Pre-Habilitation with Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)

University of Virginia

NCT05790850

RECRUITING Phase 1 29 participants

A Phase I Intravesical PPM Therapy for NMIBC

VA Office of Research and Development

NCT05519241

ACTIVE NOT RECRUITING Phase 3 1,068 participants

A Study of Sasanlimab in People With Non-muscle Invasive Bladder Cancer

Pfizer

NCT04165317

ACTIVE NOT RECRUITING Phase 3 870 participants

Intravesical BCG vs GEMDOCE in NMIBC

ECOG-ACRIN Cancer Research Group

NCT05538663

ACTIVE NOT RECRUITING 570 participants

CISTO: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer

University of Washington

NCT03933826

ACTIVE NOT RECRUITING Phase 3 367 participants

A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBT

CG Oncology

NCT06111235

ACTIVE NOT RECRUITING Phase 1 310 participants

Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations

Tyra Biosciences

NCT05544552

ACTIVE NOT RECRUITING Phase 3 190 participants

Study of Cretostimogene Given in Patients With Non-Muscle Invasive Bladder Cancer ,Unresponsive to Bacillus-Calmette-Guerin

CG Oncology

NCT04452591

ACTIVE NOT RECRUITING Phase 3 100 participants

BCG in Combination With Durvalumab in Adult BCG-naïve, High-risk NMIBC Participants

AstraZeneca

NCT05943106

ACTIVE NOT RECRUITING Phase 1 22 participants

A Phase 1/1b Study of ZH9 Treatment in Patients With Non-Muscle Invasive Bladder Cancer

Prokarium

NCT06181266

ACTIVE NOT RECRUITING Phase 1 20 participants

Study of CG0070 After Transurethral Resection in Patients With IR NMIBC

H. Lee Moffitt Cancer Center and Research Institute

NCT06253845

ACTIVE NOT RECRUITING 6 participants

Follow up of Intravesical N-803 Plus BCG in BCG-Naive Non-Muscle Invasive Bladder Cancer (NMIBC)

ImmunityBio

NCT05981131

COMPLETED 417 participants

Validation of a Urine-based Assay With Genomic Markers for Predicting Recurrence for Non-muscle Invasive Bladder Cancer

Genomic Health®

NCT02969109

COMPLETED Phase 2 30 participants

A Study of Pemigatinib in Non-muscle Invasive Bladder Cancer Patients With Recurrent Low- or Intermediate-Risk Tumors

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03914794

COMPLETED Phase 1 15 participants

Proliposomal Intravesical Paclitaxel for Treatment of Low-Grade, Stage Ta, Non Muscle Invasive Bladder Cancer

Lipac Oncology

NCT03081858

COMPLETED Phase 1 12 participants

Safety and Toxicity Study of Intravesical Instillation of TARA-002 in Adults with High-grade Non-muscle Invasive Bladder Cancer (Phase 1a)

Protara Therapeutics

NCT05085977

Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 5
Phase 3 6

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Non-muscle Invasive Bladder Cancer Trial Landscape

29 indexed Non-muscle Invasive Bladder Cancer studies · 15 recruiting (52%).

Phase mix: 6 late (III/IV) vs 17 early (I/II).

Top sponsor: CG Oncology (2 trials), 9 others listed. 29 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Non-muscle Invasive Bladder Cancer?

PlainTrial tracks 29 US clinical trials for Non-muscle Invasive Bladder Cancer, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Non-muscle Invasive Bladder Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.