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NCT07206225 · ClinicalTrials.gov registry record · Phase 1

A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer

A Phase 1 study of Non-muscle Invasive Bladder Cancer, sponsored by Pfizer.

Recruiting
Registry status
Phase 1
Development phase
294
Enrollment target
20
Study locations

NCT07206225: Recruiting Phase 1 study of Non-muscle Invasive Bladder Cancer, sponsored by Pfizer.

NCT07206225 is a Phase 1 study of Non-muscle Invasive Bladder Cancer that is actively recruiting participants, run by Pfizer. The registered enrollment target is 294 participants, above the 217-participant average among 30 other Non-muscle Invasive Bladder Cancer trials with a reported enrollment target (35% higher). The trial reports 20 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT07206225, a Phase 1 study of Non-muscle Invasive Bladder Cancer, is actively recruiting participants, sponsored by Pfizer.

RECRUITING
Registry status
Phase 1
Development phase
294 participants
Enrollment target
20
Study locations

Study Summary

The purpose of this study is to learn how a new medicine called PF-08052667 works when used by itself or together with another medicine called Bacillus Calmette Guerin (BCG), and/or a medicine called sasanlimab. This study is for adults who have a type of bladder cancer that hasn't spread into the muscle layer of the bladder but is more likely to come back or grow. It includes people whose cancer has come back or hasn't gone away after receiving standard treatments like BCG. It may also include people who, based on their doctor's opinion, cannot receive standard treatments or those treatments are not available to them. The study has three parts: * Part 1 (monotherapy dose escalation) will test PF-08052667 as a single-agent at increasing dose levels in participants with certain bladder cancer whose disease has worsened on or after standard treatments. * Part 2 (combination dose escalation) will test PF-08052667 in combination with BCG and/or sasanlimab (fixed dose) in participants with certain bladder cancer whose disease has worsened on or after standard treatments. * Part 3 (dose optimization and expansion) will further test PF-08052667 as a single agent or in combination with BCG and/or sasanlimab, at the dose(s) based on findings from Part 1 and Part 2 in participants with certain bladder cancer including those who has never received standard treatments. All participants will receive the study drug PF-08052667. Only participants in Part 2 and Part 3 of the study will also receive BCG and/or sasanlimab. PF-08052667 will be given as an intravesical infusion, which means it will be injected directly into the bladder. Sasanlimab will be given as a subcutaneous injection, which means it will be injected under the skin. For all parts, treatment with study medicines will continue until either a participant has decided to stop taking part in the study or is asked to leave the study for various reasons or up to about 2 years, whichever occurs first. Duration of trial

Primary Outcome

Any AE occurring during the DLT observation period that is attributed to PF-08052667 and not to the underlying disease or other causes is considered a DLT. DLT rate estimated based on data from DLT-evaluable participants during the DLT evaluation period.

Conditions Studied

Non-muscle Invasive Bladder Cancer

Interventions

  • DRUG PF-08052667
  • DRUG Sasanlimab
  • DRUG BCG
  • DRUG PF-02921367

Study Locations (20)

Florida

  • AdventHealth Orlando - Orlando
  • Moffitt Cancer Center at SouthShore - Ruskin
  • Moffitt Cancer Center - International Plaza - Tampa
  • Moffitt Cancer Center - McKinley Campus - Tampa
  • Moffitt Cancer Center - Tampa
  • Moffitt McKinley Hospital - Tampa
  • Moffitt Cancer Center at Wesley Chapel - Wesley Chapel

Kansas

  • The University of Kansas - Clinical Research Center - Fairway
  • The University of Kansas Hospital Cambridge North Tower A - Kansas City
  • The University of Kansas Hospital - Kansas City
  • The University of Kansas Medical Center Medical Office Building - Kansas City
  • The University of Kansas Hospital - Indian Creek Campus - Overland Park

Georgia

  • Emory University Hospital Midtown - Atlanta
  • Emory University Hospital - Atlanta
  • Emory University - Atlanta

Illinois

  • Northwestern Memorial Hospital - Chicago
  • Northwestern University - Feinberg School of Medicine - Chicago

Alabama

  • University of Alabama at Birmingham - Birmingham

California

  • UCLA Hematology/Oncology - Westwood (Building 300) - Los Angeles

Iowa

  • University of Iowa Health Care - Iowa City

Trial Details

FieldValue
Enrollment Target 294 participants
Start Date 2025-11-06
Est. Completion 2033-01-28
Phase Phase 1
Pfizer

1,845 total trials

What NCT07206225 shows while recruiting

NCT07206225 is an interventional study that assigns participants to a tested intervention. The registered 294 participants enrollment target is mid-sized for trials with a published cap, above the 217-participant average among 30 other Non-muscle Invasive Bladder Cancer trials with a reported enrollment target (35% higher).

The record links to 1 condition, with Non-muscle Invasive Bladder Cancer appearing as the primary indexed condition, and to 4 interventions - of which PF-08052667 is the first listed.

NCT07206225 names 20 study sites across 7 states, led by Florida, Kansas, Georgia.

Frequently Asked Questions

What is clinical trial NCT07206225 about?

NCT07206225 is a clinical study titled "A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer". The purpose of this study is to learn how a new medicine called PF-08052667 works when used by itself or together with another medicine called Bacillus Calmette Guerin (BCG), and/or a medicine called sasanlimab. This study is for adults who have a type of bladder cancer that hasn't spread into the ...

What is the current status of trial NCT07206225?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 294 participants. The study started on 2025-11-06. Estimated completion is 2033-01-28.

What conditions does trial NCT07206225 study?

This clinical trial studies the following conditions: Non-muscle Invasive Bladder Cancer.

What interventions are being tested in trial NCT07206225?

The interventions under investigation include: PF-08052667 (DRUG), Sasanlimab (DRUG), BCG (DRUG), PF-02921367 (DRUG).

Who is sponsoring clinical trial NCT07206225?

This trial is sponsored by Pfizer, which has 1,845 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07206225 being conducted?

This trial has 20 study locations across Alabama, California, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Non-muscle Invasive Bladder Cancer

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT07206225's enrollment target sits among peer trials

294 9th of 30 higher than 22 of 30 other Non-muscle Invasive Bladder Cancer trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Non-muscle Invasive Bladder Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT07206225

Source: ClinicalTrials.gov NCT07206225, the US trial registry maintained by the National Library of Medicine. NCT07206225 (mid enrollment · wide site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.