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ClinicalTrials.gov 4 recruiting now official registry

Mitral Valve Regurgitation clinical trials

4 of 12 indexed Mitral Valve Regurgitation trials are currently recruiting.

12 US clinical trials · 4 currently recruiting

Mitral Valve Regurgitation is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. The most active sponsor is Abbott Medical Devices, running 4 of these trials.

The research picture

Mitral Valve Regurgitation has 12 registered US clinical trials, 4 of them open to new participants right now, about 33% of the total.

4
recruiting participants now
33%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
4
top sponsor: Abbott Medical Devices

Active & Recent Trials

12 total, page 1 of 1

RECRUITING 4,000 participants

STS/ACC TVT Registry Mitral Module

American College of Cardiology

NCT02245763

RECRUITING NA 1,056 participants

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Medtronic Cardiovascular

NCT03242642

RECRUITING NA 450 participants

Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)

Annetine Gelijns

NCT05051033

RECRUITING NA 450 participants

AltaValve Pivotal Trial

4C Medical Technologies

NCT06465745

ACTIVE NOT RECRUITING 1,164 participants

MitraClip EXPAND G4 Study

Abbott Medical Devices

NCT04177394

ACTIVE NOT RECRUITING NA 500 participants

MitraClip REPAIR MR Study

Abbott Medical Devices

NCT04198870

ACTIVE NOT RECRUITING NA 53 participants

PARTNER 3 Trial - Mitral Valve in Valve

Edwards Lifesciences

NCT03193801

ACTIVE NOT RECRUITING NA 27 participants

Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System

Shockwave Medical

NCT02276547

COMPLETED 1,041 participants

The MitraClip® EXPAND Study of the Next Generation of MitraClip® Devices

Abbott Medical Devices

NCT03502811

COMPLETED NA 162 participants

Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional MR

Abbott Medical Devices

NCT07227675

COMPLETED 50 participants

New Techniques to Evaluate Mitral Regurgitation

National Heart, Lung, and Blood Institute (NHLBI)

NCT01063322

COMPLETED 3 participants

Atrioventricular Valve Regurgitation Vena Contracta; Echo Versus MRI

Medical College of Wisconsin

NCT01504880

Phase Distribution

Phase data not available

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Mitral Valve Regurgitation Trial Landscape

12 indexed Mitral Valve Regurgitation studies · 4 recruiting (33%).

Phase mix: 0 late (III/IV) vs 0 early (I/II).

Top sponsor: Abbott Medical Devices (4 trials), 8 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Mitral Valve Regurgitation?

PlainTrial tracks 12 US clinical trials for Mitral Valve Regurgitation, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Mitral Valve Regurgitation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.