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Mitral Regurgitation: early-phase trial registry
15 of 27 indexed Mitral Regurgitation trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #598 of 28,707 conditions by registered trial count.
27 US clinical trials · 15 currently recruiting · #598 of 28,707 conditions by registered trial count
Mitral Regurgitation: 27 US clinical trials tracked, 15 recruiting.
Mitral Regurgitation is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Abbott Medical Devices, running 8 of these trials.
Enrollment posture brief
Registry condition mitral-regurgitation
OPEN 15 | RECR 56% | LATE 0 | EARLY 1 | RANK #598 | SPON 8
Volume-matched condition peers
Nearest open-share peer: Acute Lymphoblastic Leukemia, Pediatric (56% recruiting · 9 trials)
Mitral Regurgitation lists 15 open slots (56% of 27 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Mitral Regurgitation on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Mitral Regurgitation is recruiting above its size-band peers.
15 of 27 indexed trials (55.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Mitral Regurgitation research.
Abbott Medical Devices accounts for 8 of 27 trials (29.6%). 17 distinct sponsors appear on at least one study for this condition label.
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Typical Mitral Regurgitation enrolment sits around 162 participants.
Median target enrolment is 162 among the 27 trials that report a genuine target (sentinel values excluded). 11 of those (40.7%) plan for fewer than 100 participants.
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Mitral Regurgitation splits between interventional and observational designs.
18 interventional and 9 observational studies make up this index (66.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
27 total, page 1 of 1
Abbott Cephea Mitral Valve Disease Registry
Abbott Medical Devices
NCT07069673
The ENCIRCLE Trial
Edwards Lifesciences
NCT04153292
CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
Universitätsklinikum Hamburg-Eppendorf
NCT04688190
Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study
Abbott Medical Devices
NCT04761120
AltaValve Pivotal Trial
4C Medical Technologies
NCT06465745
The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).
Mayra Guerrero
NCT04408430
Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease
The Cleveland Clinic
NCT06780241
Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock
Ottawa Heart Institute Research Corporation
NCT05298124
The CardioClip Study
Columbia University
NCT06241430
In Search of Best Practices for Patients With Heart Failure and Secondary Mitral Regurgitation: An Evaluation of the Inova Heart Failure Treatment Algorithm
Inova Health Care Services
NCT06675448
Cephea Early Feasibility Study
Abbott Medical Devices
NCT05061004
Use of Phenylephrine for Assessment of Mitral Regurgitation Severity
Montefiore Medical Center
NCT04500899
An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System
HighLife SAS
NCT04029337
EFS of the CardioMech MVRS
CardioMech AS
NCT04820764
Evaluating Infrasonic Hemodynography
Scripps Health
NCT04636892
Genomic Investigation of Cardiovascular Diseases
Scripps Translational Science Institute
NCT00722748
Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
Edwards Lifesciences
NCT03706833
MitraClip EXPAND G4 Study
Abbott Medical Devices
NCT04177394
Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation
Abbott Medical Devices
NCT03433274
SAPIEN M3 EFS: Early Feasibility Study of the Edwards SAPIEN M3 System for the Treatment of Mitral Regurgitation
Edwards Lifesciences
NCT03230747
Beating Heart Mitral Valve Repair With the HARPOON™ System
Edwards Lifesciences
NCT04375332
Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following MitraClip
samir kapadia
NCT04729933
Addressing Under-treatment and Health Equity in AS and MR Using an Integrated EHR Platform
Tempus AI
NCT06099665
Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes
Eko Devices
NCT04400513
The MitraClip® EXPAND Study of the Next Generation of MitraClip® Devices
Abbott Medical Devices
NCT03502811
Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional MR
Abbott Medical Devices
NCT07227675
Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification
Abbott Medical Devices
NCT03539458
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Mitral Regurgitation records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Mitral Regurgitation trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Mitral Regurgitation page
27 registered trials, 15 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 15 Mitral Regurgitation trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Abbott Medical Devices sponsors the most Mitral Regurgitation trials on record, review their full trial history before evaluating a specific study. See Abbott Medical Devices's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Mitral Regurgitation condition card totals 27 registered trials; most-linked intervention Tendyne Mitral Valve System; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.