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ClinicalTrials.gov 15 recruiting now official registry

Mitral Regurgitation clinical trials

15 of 27 indexed Mitral Regurgitation trials are currently recruiting.

27 US clinical trials · 15 currently recruiting

Mitral Regurgitation is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Abbott Medical Devices, running 8 of these trials.

The research picture

Mitral Regurgitation has 27 registered US clinical trials, 15 of them open to new participants right now, about 56% of the total.

15
recruiting participants now
56%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
8
top sponsor: Abbott Medical Devices
Phase 11

Active & Recent Trials

27 total, page 1 of 1

RECRUITING 1,000 participants

Abbott Cephea Mitral Valve Disease Registry

Abbott Medical Devices

NCT07069673

RECRUITING NA 900 participants

The ENCIRCLE Trial

Edwards Lifesciences

NCT04153292

RECRUITING 800 participants

CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

Universitätsklinikum Hamburg-Eppendorf

NCT04688190

RECRUITING 550 participants

Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study

Abbott Medical Devices

NCT04761120

RECRUITING NA 450 participants

AltaValve Pivotal Trial

4C Medical Technologies

NCT06465745

RECRUITING NA 210 participants

The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

Mayra Guerrero

NCT04408430

RECRUITING 200 participants

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

The Cleveland Clinic

NCT06780241

RECRUITING NA 144 participants

Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock

Ottawa Heart Institute Research Corporation

NCT05298124

RECRUITING NA 60 participants

The CardioClip Study

Columbia University

NCT06241430

RECRUITING 50 participants

In Search of Best Practices for Patients With Heart Failure and Secondary Mitral Regurgitation: An Evaluation of the Inova Heart Failure Treatment Algorithm

Inova Health Care Services

NCT06675448

RECRUITING NA 50 participants

Cephea Early Feasibility Study

Abbott Medical Devices

NCT05061004

RECRUITING Phase 1 35 participants

Use of Phenylephrine for Assessment of Mitral Regurgitation Severity

Montefiore Medical Center

NCT04500899

RECRUITING NA 30 participants

An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

HighLife SAS

NCT04029337

RECRUITING NA 25 participants

EFS of the CardioMech MVRS

CardioMech AS

NCT04820764

RECRUITING NA 25 participants

Evaluating Infrasonic Hemodynography

Scripps Health

NCT04636892

ACTIVE NOT RECRUITING 15,000 participants

Genomic Investigation of Cardiovascular Diseases

Scripps Translational Science Institute

NCT00722748

ACTIVE NOT RECRUITING NA 1,247 participants

Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial

Edwards Lifesciences

NCT03706833

ACTIVE NOT RECRUITING 1,164 participants

MitraClip EXPAND G4 Study

Abbott Medical Devices

NCT04177394

ACTIVE NOT RECRUITING NA 103 participants

Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Abbott Medical Devices

NCT03433274

ACTIVE NOT RECRUITING NA 72 participants

SAPIEN M3 EFS: Early Feasibility Study of the Edwards SAPIEN M3 System for the Treatment of Mitral Regurgitation

Edwards Lifesciences

NCT03230747

ACTIVE NOT RECRUITING NA 25 participants

Beating Heart Mitral Valve Repair With the HARPOON™ System

Edwards Lifesciences

NCT04375332

ACTIVE NOT RECRUITING NA 10 participants

Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following MitraClip

samir kapadia

NCT04729933

COMPLETED NA 2,118 participants

Addressing Under-treatment and Health Equity in AS and MR Using an Integrated EHR Platform

Tempus AI

NCT06099665

COMPLETED 1,145 participants

Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes

Eko Devices

NCT04400513

COMPLETED 1,041 participants

The MitraClip® EXPAND Study of the Next Generation of MitraClip® Devices

Abbott Medical Devices

NCT03502811

COMPLETED NA 162 participants

Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional MR

Abbott Medical Devices

NCT07227675

COMPLETED NA 11 participants

Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification

Abbott Medical Devices

NCT03539458

Phase Distribution

PhaseTrial count
Phase 1 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Mitral Regurgitation Trial Landscape

27 indexed Mitral Regurgitation studies · 15 recruiting (56%).

Phase mix: 0 late (III/IV) vs 1 early (I/II).

Top sponsor: Abbott Medical Devices (8 trials), 9 others listed. 27 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Mitral Regurgitation?

PlainTrial tracks 27 US clinical trials for Mitral Regurgitation, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Mitral Regurgitation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.