Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04688190 · ClinicalTrials.gov registry record
CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
A clinical trial of Mitral Regurgitation, sponsored by Universitätsklinikum Hamburg-Eppendorf.
- Recruiting
- Registry status
- 800
- Enrollment target
- 20
- Study locations
NCT04688190: Recruiting study of Mitral Regurgitation, sponsored by Universitätsklinikum Hamburg-Eppendorf.
NCT04688190 is a study of Mitral Regurgitation that is actively recruiting participants, run by Universitätsklinikum Hamburg-Eppendorf. The registered enrollment target is 800 participants, below the 993-participant average among 26 other Mitral Regurgitation trials with a reported enrollment target (19% lower). The trial reports 20 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04688190, a study of Mitral Regurgitation, is actively recruiting participants, sponsored by Universitätsklinikum Hamburg-Eppendorf.
- RECRUITING
- Registry status
- 800 participants
- Enrollment target
- 20
- Study locations
Study Summary
This multinational, investigator-initiated, retrospective study aims to investigate outcomes of patients, who underwent transcatheter mitral valve implantation (TMVI), in comparison to those screened for TMVI but deemed ineligible, who subsequently underwent interventional mitral valve edge-to-edge repair, mitral valve surgery or medical/conservative therapy.
Primary Outcome
Mitral insufficiency measured by transthoracic echocardiography. Assessment of MI severity according to current guidelines (ESC/EACTS and ACC/AHA) for valvular heart disease.
Conditions Studied
Study Locations (20)
Other
- St Vincent's Hospital - Sydney
- Toronto Heart Center - Toronto
- St. Paul's Hospital - Vancouver
- Rigshospitalet - Copenhagen
- CHU Bordeaux - Bourdeaux
- Lille University Hospital - Lille
- Civils Hospices of Lyon - Lyon
- Clinique Pasteur - Toulouse
- HDZ Bad Oeynhausen - Bad Oeynhausen
- German Heart Center Berlin - Berlin
- Heart Center Bonn - Bonn
- University Hospital of Cologne - Cologne
- Goethe-Universität - University Hospital Frankfurt - Frankfurt
- University Heart and Vascular Center Hamburg - Hamburg
- Heart Center of the University Medical Center Mainz - Mainz
- German Heart Centre Munich - Munich
- LMU Munich - Munich
California
- Cedars-Sinai Medical Center, Los Angeles - Los Angeles
Massachusetts
- Brigham and Women's Hospital - Boston
Texas
- Houston Methodist Hospital - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 800 participants |
| Start Date | 2020-11-01 |
| Est. Completion | 2030-12-31 |
What NCT04688190 shows while recruiting
NCT04688190 is an observational study that tracks outcomes without assigning an intervention. The registered 800 participants enrollment target is mid-sized for trials with a published cap, below the 993-participant average among 26 other Mitral Regurgitation trials with a reported enrollment target (19% lower).
The record links to 1 condition, with Mitral Regurgitation appearing as the primary indexed condition, and to 0 interventions.
NCT04688190 names 20 study sites across 4 states, led by Other, California, Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04688190 about?
NCT04688190 is a clinical study titled "CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry". This multinational, investigator-initiated, retrospective study aims to investigate outcomes of patients, who underwent transcatheter mitral valve implantation (TMVI), in comparison to those screened for TMVI but deemed ineligible, who subsequently underwent interventional mitral valve edge-to-edge ...
What is the current status of trial NCT04688190?
This trial is currently recruiting. The enrollment target is 800 participants. The study started on 2020-11-01. Estimated completion is 2030-12-31.
What conditions does trial NCT04688190 study?
This clinical trial studies the following conditions: Mitral Regurgitation.
Who is sponsoring clinical trial NCT04688190?
This trial is sponsored by Universitätsklinikum Hamburg-Eppendorf, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04688190 being conducted?
This trial has 20 study locations across California, Massachusetts, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mitral Regurgitation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04688190's enrollment target sits among peer trials
800 9th of 26 higher than 18 of 26 other Mitral Regurgitation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mitral Regurgitation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System
RECRUITING · NA
-
The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).
RECRUITING · NA
-
EFS of the CardioMech MVRS
RECRUITING · NA
-
Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study
RECRUITING
-
Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease
RECRUITING
-
In Search of Best Practices for Patients With Heart Failure and Secondary Mitral Regurgitation: An Evaluation of the Inova Heart Failure Treatment Algorithm
RECRUITING
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00695214 · 800 participants · Phase 2
Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea
- NCT03048201 · 800 participants · NA
Physica System Total Knee Replacement Registry Study
- NCT03792659 · 800 participants
The EXPLORE MG Registry for Myasthenia Gravis
- NCT03819296 · 800 participants · Phase 1
Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI