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ACTIVE NOT RECRUITING Phase 3

High-Dose Interferon Alfa in Treating Patients With Stage II or Stage III Melanoma

NCT00003641 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Interferon alfa may interfere with the growth of cancer cells. It is not yet known whether treatment with interferon alfa is more effective than observation alone for stage II or stage III melanoma that has been completely removed surgically. PURPOSE: This randomized phase III trial is studying high dose interferon alfa to see how well it works compared to observation only in treating patients with stage II or stage III melanoma that has been completely removed by surgery.

Conditions Studied

Interventions

  • BIOLOGICAL interferon alfa-2b
  • OTHER observation

Study Locations (20)

California

  • Kaiser Permanente - Deer Valley — Antioch
  • Alta Bates Summit Comprehensive Cancer Center — Berkeley
  • Peninsula Medical Center — Burlingame
  • Southern California Permanente Medical Group — Downey
  • Kaiser Permanente - Fremont — Fremont
  • Marin Cancer Institute at Marin General Hospital — Greenbrae
  • Kaiser Permanente Medical Center - Hayward — Hayward
  • Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda
  • Kaiser Permanente Medical Center - Oakland — Oakland
  • Veterans Affairs Medical Center - Palo Alto — Palo Alto
  • Kaiser Permanente Medical Center - Redwood City — Redwood City
  • Kaiser Permanente Medical Center - Richmond — Richmond
  • Kaiser Permanente Medical Center - Roseville — Roseville
  • Sutter Cancer Center at Roseville Medical Center — Roseville
  • Sutter Cancer Center — Sacramento

Alabama

  • UAB Comprehensive Cancer Center — Birmingham
  • University of South Alabama Mitchell Cancer Institute — Mobile

Arkansas

  • Hembree Mercy Cancer Center at St. Edward Mercy Medical Center — Fort Smith
  • Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock

Arizona

  • Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson

Trial Details

FieldValue
Enrollment Target 1,150 participants
Start Date 1999-03-25
Est. Completion 2026-12
Phase Phase 3

Sponsor

ECOG-ACRIN Cancer Research Group

52 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00003641

The ClinicalTrials.gov registry entry for NCT00003641 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,150 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ECOG-ACRIN Cancer Research Group, which has 52 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Melanoma (Skin) appearing as the primary indexed condition, and to 2 interventions — of which interferon alfa-2b is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00003641 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Alabama, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00003641 about?

NCT00003641 is a clinical study titled "High-Dose Interferon Alfa in Treating Patients With Stage II or Stage III Melanoma". RATIONALE: Interferon alfa may interfere with the growth of cancer cells. It is not yet known whether treatment with interferon alfa is more effective than observation alone for stage II or stage III melanoma that has been completely removed surgically. PURPOSE: This randomized phase III trial is s...

What is the current status of trial NCT00003641?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 1,150 participants. The study started on 1999-03-25. Estimated completion is 2026-12.

What conditions does trial NCT00003641 study?

This clinical trial studies the following conditions: Melanoma (Skin). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00003641?

The interventions under investigation include: interferon alfa-2b (BIOLOGICAL), observation (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00003641?

This trial is sponsored by ECOG-ACRIN Cancer Research Group, which has 52 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00003641 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial