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ClinicalTrials.gov 8 recruiting now official registry

Mechanical Ventilation clinical trials

8 of 15 indexed Mechanical Ventilation trials are currently recruiting.

15 US clinical trials · 8 currently recruiting

Mechanical Ventilation is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is McMaster University, running 2 of these trials.

The research picture

Mechanical Ventilation has 15 registered US clinical trials, 8 of them open to new participants right now, about 53% of the total.

8
recruiting participants now
53%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: McMaster University
Phase 22Phase 31

Active & Recent Trials

15 total, page 1 of 1

RECRUITING NA 3,090 participants

The ED-AWARENESS-2 Trial

Washington University School of Medicine

NCT05534243

RECRUITING NA 1,200 participants

RCT: Early Feeding After PEG Placement

Carilion Clinic

NCT04110613

RECRUITING NA 800 participants

Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.

The University of Texas Medical Branch, Galveston

NCT06737432

RECRUITING Phase 3 644 participants

Optimizing Pain Treatment in Children On Mechanical Ventilation

Weill Medical College of Cornell University

NCT06994442

RECRUITING Phase 2 300 participants

Fentanyl Versus Hydromorphone in Patients on Mechanical Ventilation

Beth Israel Deaconess Medical Center

NCT07224620

RECRUITING NA 238 participants

Prognostic Estimates Among ICU Clinicians

Rush University Medical Center

NCT06452797

RECRUITING NA 170 participants

Analgesia-First Sedation in Trauma Patients

MemorialCare Health System

NCT05751863

RECRUITING NA 110 participants

The Effects of Endotracheal Suctioning on Pain and Serum Markers

Loma Linda University

NCT06692400

ACTIVE NOT RECRUITING NA 360 participants

CYCLE: A Randomized Clinical Trial of Early In-bed Cycling for Mechanically Ventilated Patients

McMaster University

NCT03471247

ACTIVE NOT RECRUITING 312 participants

Measuring Outcomes of Activity in Intensive Care

Vanderbilt University Medical Center

NCT03115840

ACTIVE NOT RECRUITING NA 300 participants

Titration of Oxygen Levels During Mechanical Ventilation With Electronic Alerts

Ohio State University

NCT04481581

COMPLETED 680 participants

Implementation of an Analgesia-sedation Algorithm in the Pediatric ICU to Reduce Benzodiazepine Use

Boston Children's Hospital

NCT04263662

COMPLETED Phase 2 113 participants

CYCLE Pilot Randomized Trial

McMaster University

NCT02377830

COMPLETED 30 participants

Variability Analysis as a Predictor of Liberation From Mechanical Ventilation

The Cleveland Clinic

NCT01140750

COMPLETED NA 15 participants

The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures

Massachusetts General Hospital

NCT01969227

Phase Distribution

PhaseTrial count
Phase 2 2
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Mechanical Ventilation Trial Landscape

15 indexed Mechanical Ventilation studies · 8 recruiting (53%).

Phase mix: 1 late (III/IV) vs 2 early (I/II).

Top sponsor: McMaster University (2 trials), 9 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Mechanical Ventilation?

PlainTrial tracks 15 US clinical trials for Mechanical Ventilation, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Mechanical Ventilation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.