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Mechanical Ventilation clinical trials
Every US clinical trial registered for Mechanical Ventilation — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
15 US clinical trials · 8 currently recruiting
The research picture
Mechanical Ventilation has 15 registered US clinical trials, 8 of them open to new participants right now — about 53% of the total.
- 8
- recruiting participants now
- 53%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 2
- top sponsor: McMaster University
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
The ED-AWARENESS-2 Trial
Washington University School of Medicine
NCT05534243
RCT: Early Feeding After PEG Placement
Carilion Clinic
NCT04110613
Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.
The University of Texas Medical Branch, Galveston
NCT06737432
Optimizing Pain Treatment in Children On Mechanical Ventilation
Weill Medical College of Cornell University
NCT06994442
Fentanyl Versus Hydromorphone in Patients on Mechanical Ventilation
Beth Israel Deaconess Medical Center
NCT07224620
Prognostic Estimates Among ICU Clinicians
Rush University Medical Center
NCT06452797
Analgesia-First Sedation in Trauma Patients
MemorialCare Health System
NCT05751863
The Effects of Endotracheal Suctioning on Pain and Serum Markers
Loma Linda University
NCT06692400
CYCLE: A Randomized Clinical Trial of Early In-bed Cycling for Mechanically Ventilated Patients
McMaster University
NCT03471247
Measuring Outcomes of Activity in Intensive Care
Vanderbilt University Medical Center
NCT03115840
Titration of Oxygen Levels During Mechanical Ventilation With Electronic Alerts
Ohio State University
NCT04481581
Implementation of an Analgesia-sedation Algorithm in the Pediatric ICU to Reduce Benzodiazepine Use
Boston Children's Hospital
NCT04263662
CYCLE Pilot Randomized Trial
McMaster University
NCT02377830
Variability Analysis as a Predictor of Liberation From Mechanical Ventilation
The Cleveland Clinic
NCT01140750
The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
Massachusetts General Hospital
NCT01969227
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Mechanical Ventilation Trial Landscape
ClinicalTrials.gov lists 15 US studies indexed under Mechanical Ventilation, and 8 of those are currently open to recruitment — roughly 53% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Mechanical Ventilation shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Mechanical Ventilation is led by McMaster University with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 15 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Mechanical Ventilation?
PlainTrial tracks 15 US clinical trials for Mechanical Ventilation, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Mechanical Ventilation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.