Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Optimizing Pain Treatment in Children On Mechanical Ventilation
NCT06994442 · View on ClinicalTrials.gov ↗
Study Summary
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure. Right now, doctors give these children opioids to help with pain while they are on the ventilator, but investigators don't know if this is the best way to manage their pain. Even with strong doses of opioids, more than 90% of these children still feel pain. Other pain medicines, like acetaminophen (also called Tylenol) and ketorolac (also called Toradol), are available but aren't commonly used because we don't know if they help. The goal of this clinical trial is to test if acetaminophen and/or ketorolac can improve pain control and reduce the need for stronger pain medications (opioids) in these children. To learn more about this, participants will be randomly placed in one of four study treatment groups. This means that a computer will decide by chance which group each participant is in, not the doctors running the study. Each group will receive a combination of intravenous acetaminophen, ketorolac or a harmless substance called a placebo. In this clinical trial, placebos help investigators see if the actual medications (acetaminophen and ketorolac) work better than something that doesn't contain medicine. By comparing participants who get the real medicine with those who get the placebo, investigators can find out if these medications effectively decrease pain.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Acetaminophen
- DRUG Ketorolac
Study Locations (15)
Pennsylvania
- Penn State Health/Hershey Medical Center — Hershey
- Children's Hospital of Philadelphia — Philadelphia
- University of Pittsburgh — Pittsburgh
Michigan
- University of Michigan — Ann Arbor
- Children's Hospital of Michigan — Detroit
Ohio
- Rainbow Babies and Children's Hospital — Cleveland
- Nationwide Children's Hospital — Columbus
Arkansas
- Arkansas Children's Hospital — Little Rock
District of Columbia
- Children's National Hospital — Washington D.C.
Minnesota
- University of Minnesota — Minneapolis
North Carolina
- Duke Children's Hospital & Health Center — Durham
South Carolina
- Medical University of South Carolina — Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 644 participants |
| Start Date | 2025-12-29 |
| Est. Completion | 2029-08-31 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06994442
The ClinicalTrials.gov registry entry for NCT06994442 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 644 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Weill Medical College of Cornell University, which has 679 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Mechanical Ventilation appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06994442 reports 15 study locations spanning 11 distinct geographic areas — top geographies include Pennsylvania, Michigan, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06994442 about?
NCT06994442 is a clinical study titled "Optimizing Pain Treatment in Children On Mechanical Ventilation". In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure. Right now, doctors give these children opioids to help with pain while they are on the ventilator, but investigators don't know if this is the best way to man...
What is the current status of trial NCT06994442?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 644 participants. The study started on 2025-12-29. Estimated completion is 2029-08-31.
What conditions does trial NCT06994442 study?
This clinical trial studies the following conditions: Mechanical Ventilation, Sedation and Analgesia, Analgesics, Opioid, Pediatric Acute Respiratory Failure. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06994442?
The interventions under investigation include: Placebo (DRUG), Acetaminophen (DRUG), Ketorolac (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06994442?
This trial is sponsored by Weill Medical College of Cornell University, which has 679 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06994442 being conducted?
This trial has 15 study locations across Arkansas, District of Columbia, Michigan, Minnesota, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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