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NCT04481581 · ClinicalTrials.gov registry record · NA
Titration of Oxygen Levels During Mechanical Ventilation With Electronic Alerts
A NA study of Mechanical Ventilation, sponsored by Ohio State University.
- Active
- Registry status
- NA
- Development phase
- 300
- Enrollment target
- 1
- Study location
NCT04481581: Active NA study of Mechanical Ventilation, sponsored by Ohio State University.
NCT04481581 is a NA study of Mechanical Ventilation that is active but no longer recruiting, run by Ohio State University. The registered enrollment target is 300 participants, below the 576-participant average among 14 other Mechanical Ventilation trials with a reported enrollment target (48% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04481581, a NA study of Mechanical Ventilation, is active but no longer recruiting, sponsored by Ohio State University.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 300 participants
- Enrollment target
- 1
- Study location
Study Summary
Fractional oxygen during mechanical ventilation, is a life sustaining therapy in the intensive care unit , used for about a million patients annually. Oxygen therapy needs to be tightly balanced as both hypoxia and hyperoxia are harmful. Establishing precision in oxygenation has significant implications for improving patient outcomes, resource utilization and reducing iatrogenic harm to a vulnerable population. The investigators propose an approach using a oxygen titration protocol consisting of electronic health records based alerts to guide oxygen adjustment.
Primary Outcome
The degree of excess exposure will be recorded as percent FiO2 \>0.4 when saturation continued to remain above 94%. Primary outcome will be determined by the proportion of time the patient will be "exposed to excessive supplied oxygen" divided by the total time under mechanical ventilation.
Conditions Studied
Interventions
- OTHER Electronic Alerts
Study Locations (1)
Ohio
- Ohio State University Medical Center - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2021-01-05 |
| Est. Completion | 2025-10-01 |
| Phase | NA |
What the registry record for NCT04481581 still lists
NCT04481581 is an interventional study that assigns participants to a tested intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, below the 576-participant average among 14 other Mechanical Ventilation trials with a reported enrollment target (48% lower).
The record links to 1 condition, with Mechanical Ventilation appearing as the primary indexed condition, and to 1 intervention - of which Electronic Alerts is the first listed.
NCT04481581 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT04481581 about?
NCT04481581 is a clinical study titled "Titration of Oxygen Levels During Mechanical Ventilation With Electronic Alerts". Fractional oxygen during mechanical ventilation, is a life sustaining therapy in the intensive care unit , used for about a million patients annually. Oxygen therapy needs to be tightly balanced as both hypoxia and hyperoxia are harmful. Establishing precision in oxygenation has significant implicat...
What is the current status of trial NCT04481581?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 300 participants. The study started on 2021-01-05. Estimated completion is 2025-10-01.
What conditions does trial NCT04481581 study?
This clinical trial studies the following conditions: Mechanical Ventilation.
What interventions are being tested in trial NCT04481581?
The interventions under investigation include: Electronic Alerts (OTHER).
Who is sponsoring clinical trial NCT04481581?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04481581 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mechanical Ventilation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04481581's enrollment target sits among peer trials
300 8th of 14 higher than 6 of 14 other Mechanical Ventilation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mechanical Ventilation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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