Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01969227 · ClinicalTrials.gov registry record · NA
The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
A NA study of Mechanical Ventilation and Respiratory Depression, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- NA
- Development phase
- 15
- Enrollment target
- 2
- Study locations
NCT01969227 is a NA study of Mechanical Ventilation and Respiratory Depression that has completed, run by Massachusetts General Hospital. The registered enrollment target is 15 participants, below the 596-participant average among 14 other Mechanical Ventilation trials with a reported enrollment target (97% lower). The trial reports 2 study locations across 1 state.
The verdict
NCT01969227, a NA study of Mechanical Ventilation and Respiratory Depression, has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 15 participants
- Enrollment target
- 2
- Study locations
Study Summary
Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodilation. At subanesthetic plasma concentration, ketamine reduces both opioid and propofol requirements. The purpose of this pharmaco-physiological interaction trial is to evaluate the effects of ketamine on breathing and electroencephalography in mechanically ventilated patients.
Conditions Studied
Interventions
- DRUG Subanesthetic ketamine
Study Locations (2)
Massachusetts
- Massachusetts General Hospital - Boston
- Beth Israel Deaconess Medical Center - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2014-01 |
| Est. Completion | 2022-12 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01969227
The ClinicalTrials.gov registry entry for NCT01969227 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 596-participant average among 14 other Mechanical Ventilation trials with a reported enrollment target (97% lower). The listed sponsor is Massachusetts General Hospital, which has 2,032 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Mechanical Ventilation appearing as the primary indexed condition, and to 1 intervention - of which Subanesthetic ketamine is the first listed.
NCT01969227 reports 2 study locations spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT01969227 about?
NCT01969227 is a clinical study titled "The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures". Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodilation. At subanesthet...
What is the current status of trial NCT01969227?
This trial is currently completed. It is a NA study. The enrollment target is 15 participants. The study started on 2014-01. Estimated completion is 2022-12.
What conditions does trial NCT01969227 study?
This clinical trial studies the following conditions: Mechanical Ventilation, Respiratory Depression, Airway Patency.
What interventions are being tested in trial NCT01969227?
The interventions under investigation include: Subanesthetic ketamine (DRUG).
Who is sponsoring clinical trial NCT01969227?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01969227 being conducted?
This trial has 2 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mechanical Ventilation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Analgesia-First Sedation in Trauma Patients
RECRUITING · NA
-
RCT: Early Feeding After PEG Placement
RECRUITING · NA
-
Prognostic Estimates Among ICU Clinicians
RECRUITING · NA
-
The ED-AWARENESS-2 Trial
RECRUITING · NA
-
The Effects of Endotracheal Suctioning on Pain and Serum Markers
RECRUITING · NA
-
Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.
RECRUITING · NA
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.