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NCT01969227 · ClinicalTrials.gov registry record · NA
The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
A NA study of Mechanical Ventilation and Respiratory Depression, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- NA
- Development phase
- 15
- Enrollment target
- 2
- Study locations
NCT01969227: Completed NA study of Mechanical Ventilation and Respiratory Depression, sponsored by Massachusetts General Hospital.
NCT01969227 is a NA study of Mechanical Ventilation and Respiratory Depression that has completed, run by Massachusetts General Hospital. The registered enrollment target is 15 participants, below the 596-participant average among 14 other Mechanical Ventilation trials with a reported enrollment target (97% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01969227, a NA study of Mechanical Ventilation and Respiratory Depression, has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 15 participants
- Enrollment target
- 2
- Study locations
Study Summary
Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodilation. At subanesthetic plasma concentration, ketamine reduces both opioid and propofol requirements. The purpose of this pharmaco-physiological interaction trial is to evaluate the effects of ketamine on breathing and electroencephalography in mechanically ventilated patients.
Primary Outcome
Inspiratory airflow measured during spontaneous breathing trials without ventilator support using a calibrated pneumotachometer connected to the ventilatory circuit. Airflow signals were recorded along with airway and esophageal pressures and analyzed. Inspiratory airflow represents the rate of air entering the lungs during inspiration and is reported in liters per second (L/s). Higher values indicate greater inspiratory airflow during spontaneous breathing. Measurements were obtained during bri
Conditions Studied
Interventions
- DRUG Subanesthetic ketamine
Study Locations (2)
Massachusetts
- Massachusetts General Hospital - Boston
- Beth Israel Deaconess Medical Center - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2014-01 |
| Est. Completion | 2022-12 |
| Phase | NA |
What the finished NCT01969227 record still lists
NCT01969227 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 596-participant average among 14 other Mechanical Ventilation trials with a reported enrollment target (97% lower).
The record links to 3 conditions, with Mechanical Ventilation appearing as the primary indexed condition, and to 1 intervention - of which Subanesthetic ketamine is the first listed.
NCT01969227 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT01969227 about?
NCT01969227 is a clinical study titled "The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures". Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodilation. At subanesthet...
What is the current status of trial NCT01969227?
This trial is currently completed. It is a NA study. The enrollment target is 15 participants. The study started on 2014-01. Estimated completion is 2022-12.
What conditions does trial NCT01969227 study?
This clinical trial studies the following conditions: Mechanical Ventilation, Respiratory Depression, Airway Patency.
What interventions are being tested in trial NCT01969227?
The interventions under investigation include: Subanesthetic ketamine (DRUG).
Who is sponsoring clinical trial NCT01969227?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01969227 being conducted?
This trial has 2 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT01969227's enrollment target sits among peer trials
15 15th of 14 the lowest of 14 other Mechanical Ventilation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mechanical Ventilation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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