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Malignant Melanoma
Open-data reference.
29 US clinical trials · 7 currently recruiting
Active & Recent Trials
The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors
VastBiome
NCT05037825
A Clinical Study of V940 and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)
Merck Sharp & Dohme
NCT06961006
Study to Evaluate LB-LR1109, Administered Alone for the Treatment of Solid Tumor and in Combination With Atezolizumab for the Treatment of NSCLC
LG Chem
NCT06332755
A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
Compass Therapeutics
NCT06150664
Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies
BioEclipse Therapeutics
NCT04282044
GD2-SADA:177Lu-DOTA Complex in Patients With Solid Tumors Known to Express GD2
Y-mAbs Therapeutics
NCT05130255
RAPA-201 Therapy of Solid Tumors
Rapa Therapeutics
NCT05144698
Phase II Study Incorporating Pegylated Interferon In the Treatment For Children With High-Risk Melanoma
St. Jude Children's Research Hospital
NCT00539591
Phase Ib of L-NMMA and Pembrolizumab
The Methodist Hospital Research Institute
NCT03236935
A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies
Pfizer
NCT06974734
Oral Decitabine/Cedazuridine (DEC-C) in Combination With Nivolumab for Patients With Mucosal Melanoma
University of Colorado, Denver
NCT05089370
SciBase International Melanoma Pivotal Study
SciBase AB
NCT01077050
A Trial of ABI-007 Versus Dacarbazine in Previously Untreated Patients With Metastatic Malignant Melanoma
Celgene
NCT00864253
A Study Comparing Vemurafenib Versus Vemurafenib Plus Cobimetinib in Participants With Metastatic Melanoma
Hoffmann-La Roche
NCT01689519
A Study Of PF-05082566 As A Single Agent And In Combination With Rituximab
Pfizer
NCT01307267
Phase II Trial of Allovectin-7® for Metastatic Melanoma
Vical
NCT00044356
A Study of Vemurafenib and GDC-0973 (Cobimetinib) in Participants With BRAFV600E Mutation-Positive Metastatic Melanoma
Hoffmann-La Roche
NCT01271803
Comparison of Video-Based Versus Written Patient Education on Melanoma
University of California, Davis
NCT00826995
A Pharmacokinetic/Pharmacodynamic Study of RO5185426 in Previously Treated Patients With Metastatic Melanoma
Hoffmann-La Roche
NCT01107418
GM-CSF as Adjuvant Therapy of Melanoma
Northern California Melanoma Center
NCT00350597
A Study of Combination Treatment With HF10 and Ipilimumab in Patients With Unresectable or Metastatic Melanoma
Takara Bio
NCT02272855
A Study of MDX-1106 in Patients With Selected Refractory or Relapsed Malignancies
Bristol-Myers Squibb
NCT00441337
Phase 1B Study Evaluating Alternative Routes of Administration of CMP-001 in Combination With Pembrolizumab in Participants With Advanced Melanoma
Regeneron Pharmaceuticals
NCT03084640
An Open-Label, Dose-Escalation Study of IMC-20D7S In Participants With Malignant Melanoma
Eli Lilly and Company
NCT01137006
A Study of the Safety and Tolerance of CAN04 and Pembrolizumab in Combination With and Without Carboplatin and Pemetrexed in Subjects With Solid Tumors
Cantargia AB
NCT04452214
Study of the Tumor Saturation and Biological Activity of MEDI-522 (Abergrin) in Patients With Advanced Malignant Melanoma
MedImmune
NCT00111696
In Vitro Expanded Autologous Invariant Natural Killer Cells in Cancer
Beth Israel Deaconess Medical Center
NCT00631072
Vaccine Treatment for Advanced Malignant Melanoma
NewLink Genetics Corporation
NCT00300612
Pilot Study of Vigil™ + Pembrolizumab for Advanced Melanoma
Gradalis
NCT02574533
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 19 |
| Phase 2 | 5 |
| Phase 3 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Malignant Melanoma Trial Landscape
ClinicalTrials.gov lists 29 US studies indexed under Malignant Melanoma, and 7 of those are currently open to recruitment — roughly 24% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Malignant Melanoma shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 24 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Malignant Melanoma is led by Hoffmann-La Roche with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 29 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Malignant Melanoma?
PlainTrial tracks 29 US clinical trials for Malignant Melanoma, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Malignant Melanoma?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.