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ClinicalTrials.gov 7 recruiting now official registry

Malignant Melanoma clinical trials

7 of 29 indexed Malignant Melanoma trials are currently recruiting.

29 US clinical trials · 7 currently recruiting

Malignant Melanoma is the subject of 29 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 24 in Phase 1-2 (earlier-stage). The most active sponsor is Hoffmann-La Roche, running 3 of these trials.

The research picture

Malignant Melanoma has 29 registered US clinical trials, 7 of them open to new participants right now, about 24% of the total.

7
recruiting participants now
24%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
3
top sponsor: Hoffmann-La Roche
Phase 119Phase 25Phase 32

Active & Recent Trials

29 total, page 1 of 1

RECRUITING 800 participants

The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors

VastBiome

NCT05037825

RECRUITING Phase 2 160 participants

A Clinical Study of V940 and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

Merck Sharp & Dohme

NCT06961006

RECRUITING Phase 1 76 participants

Study to Evaluate LB-LR1109, Administered Alone for the Treatment of Solid Tumor and in Combination With Atezolizumab for the Treatment of NSCLC

LG Chem

NCT06332755

RECRUITING Phase 1 73 participants

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

Compass Therapeutics

NCT06150664

RECRUITING Phase 1 60 participants

Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

BioEclipse Therapeutics

NCT04282044

RECRUITING Phase 1 60 participants

GD2-SADA:177Lu-DOTA Complex in Patients With Solid Tumors Known to Express GD2

Y-mAbs Therapeutics

NCT05130255

RECRUITING Phase 1 37 participants

RAPA-201 Therapy of Solid Tumors

Rapa Therapeutics

NCT05144698

ACTIVE NOT RECRUITING Phase 2 29 participants

Phase II Study Incorporating Pegylated Interferon In the Treatment For Children With High-Risk Melanoma

St. Jude Children's Research Hospital

NCT00539591

ACTIVE NOT RECRUITING Phase 1 12 participants

Phase Ib of L-NMMA and Pembrolizumab

The Methodist Hospital Research Institute

NCT03236935

ACTIVE NOT RECRUITING Phase 1 9 participants

A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies

Pfizer

NCT06974734

ACTIVE NOT RECRUITING Phase 1 8 participants

Oral Decitabine/Cedazuridine (DEC-C) in Combination With Nivolumab for Patients With Mucosal Melanoma

University of Colorado, Denver

NCT05089370

COMPLETED NA 1,951 participants

SciBase International Melanoma Pivotal Study

SciBase AB

NCT01077050

COMPLETED Phase 3 529 participants

A Trial of ABI-007 Versus Dacarbazine in Previously Untreated Patients With Metastatic Malignant Melanoma

Celgene

NCT00864253

COMPLETED Phase 3 495 participants

A Study Comparing Vemurafenib Versus Vemurafenib Plus Cobimetinib in Participants With Metastatic Melanoma

Hoffmann-La Roche

NCT01689519

COMPLETED Phase 1 190 participants

A Study Of PF-05082566 As A Single Agent And In Combination With Rituximab

Pfizer

NCT01307267

COMPLETED Phase 2 133 participants

Phase II Trial of Allovectin-7® for Metastatic Melanoma

Vical

NCT00044356

COMPLETED Phase 1 131 participants

A Study of Vemurafenib and GDC-0973 (Cobimetinib) in Participants With BRAFV600E Mutation-Positive Metastatic Melanoma

Hoffmann-La Roche

NCT01271803

COMPLETED NA 78 participants

Comparison of Video-Based Versus Written Patient Education on Melanoma

University of California, Davis

NCT00826995

COMPLETED Phase 1 52 participants

A Pharmacokinetic/Pharmacodynamic Study of RO5185426 in Previously Treated Patients With Metastatic Melanoma

Hoffmann-La Roche

NCT01107418

COMPLETED Phase 2 50 participants

GM-CSF as Adjuvant Therapy of Melanoma

Northern California Melanoma Center

NCT00350597

COMPLETED Phase 2 46 participants

A Study of Combination Treatment With HF10 and Ipilimumab in Patients With Unresectable or Metastatic Melanoma

Takara Bio

NCT02272855

COMPLETED Phase 1 39 participants

A Study of MDX-1106 in Patients With Selected Refractory or Relapsed Malignancies

Bristol-Myers Squibb

NCT00441337

COMPLETED Phase 1 30 participants

Phase 1B Study Evaluating Alternative Routes of Administration of CMP-001 in Combination With Pembrolizumab in Participants With Advanced Melanoma

Regeneron Pharmaceuticals

NCT03084640

COMPLETED Phase 1 27 participants

An Open-Label, Dose-Escalation Study of IMC-20D7S In Participants With Malignant Melanoma

Eli Lilly and Company

NCT01137006

COMPLETED Phase 1 19 participants

A Study of the Safety and Tolerance of CAN04 and Pembrolizumab in Combination With and Without Carboplatin and Pemetrexed in Subjects With Solid Tumors

Cantargia AB

NCT04452214

COMPLETED Phase 1 18 participants

Study of the Tumor Saturation and Biological Activity of MEDI-522 (Abergrin) in Patients With Advanced Malignant Melanoma

MedImmune

NCT00111696

COMPLETED Phase 1 9 participants

In Vitro Expanded Autologous Invariant Natural Killer Cells in Cancer

Beth Israel Deaconess Medical Center

NCT00631072

COMPLETED Phase 1 6 participants

Vaccine Treatment for Advanced Malignant Melanoma

NewLink Genetics Corporation

NCT00300612

COMPLETED Phase 1 2 participants

Pilot Study of Vigil™ + Pembrolizumab for Advanced Melanoma

Gradalis

NCT02574533

Phase Distribution

PhaseTrial count
Phase 1 19
Phase 2 5
Phase 3 2

Top Sponsors

Pfizer 2 trials
SciBase AB 1 trials
Vical 1 trials
Cantargia AB 1 trials
Takara Bio 1 trials
Gradalis 1 trials
MedImmune 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Malignant Melanoma Trial Landscape

29 indexed Malignant Melanoma studies · 7 recruiting (24%).

Phase mix: 2 late (III/IV) vs 24 early (I/II).

Top sponsor: Hoffmann-La Roche (3 trials), 9 others listed. 29 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Malignant Melanoma?

PlainTrial tracks 29 US clinical trials for Malignant Melanoma, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Malignant Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.