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RECRUITING Phase 2

A Clinical Study of V940 and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

NCT06961006 · View on ClinicalTrials.gov ↗

Study Summary

Researchers want to learn if V940 with pembrolizumab can stop advanced melanoma from growing or spreading. Melanoma is a type of skin cancer. Advanced means the cancer has spread to other parts of the body and cannot be removed with surgery. A standard (or usual) treatment for advanced melanoma is immunotherapy. Immunotherapy is a treatment that helps the immune system fight cancer. V940 is a study treatment designed to help a person's immune system attack their specific cancer. Pembrolizumab is an immunotherapy. The goal of this study is to learn if people who receive V940 with pembrolizumab live longer without the cancer growing or spreading than people who receive placebo with pembrolizumab. A placebo looks like the study treatment but has no study treatment in it. Using a placebo helps researchers better understand the effects of a study treatment.

Conditions Studied

Interventions

  • BIOLOGICAL Pembrolizumab
  • OTHER Placebo
  • BIOLOGICAL V940

Study Locations (20)

New South Wales

  • Blacktown Hospital ( Site 2001) — Blacktown
  • Melanoma Institute Australia ( Site 2000) — Wollstonecraft

Ontario

  • William Osler Health System (Brampton Civic Hospital) ( Site 2023) — Brampton
  • Sunnybrook Research Institute ( Site 2022) — Toronto

Île-de-France Region

  • Hôpital Saint-Louis ( Site 2041) — Paris
  • Gustave Roussy ( Site 2040) — Villejuif

North Rhine-Westphalia

  • Universitaetsklinikum Koeln ( Site 2064) — Cologne
  • Universitaetsklinikum Essen ( Site 2061) — Essen

Attica

  • General Hospital of Athens "Laiko" ( Site 2080) — Athens
  • Metropolitan Hospital ( Site 2082) — Athens

Arkansas

  • Highlands Oncology Group ( Site 4042) — Springdale

California

  • UCSF Medical Center at Mission Bay ( Site 4044) — San Francisco

New Jersey

  • John Theurer Cancer Center at Hackensack University Medical Center ( Site 4047) — Hackensack

Trial Details

FieldValue
Enrollment Target 160 participants
Start Date 2025-05-29
Est. Completion 2031-09-05
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06961006

The ClinicalTrials.gov registry entry for NCT06961006 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 160 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Malignant Melanoma appearing as the primary indexed condition, and to 3 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06961006 reports 20 study locations spanning 15 distinct geographic areas — top geographies include New South Wales, Ontario, Île-de-France Region. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06961006 about?

NCT06961006 is a clinical study titled "A Clinical Study of V940 and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)". Researchers want to learn if V940 with pembrolizumab can stop advanced melanoma from growing or spreading. Melanoma is a type of skin cancer. Advanced means the cancer has spread to other parts of the body and cannot be removed with surgery. A standard (or usual) treatment for advanced melanoma is i...

What is the current status of trial NCT06961006?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 160 participants. The study started on 2025-05-29. Estimated completion is 2031-09-05.

What conditions does trial NCT06961006 study?

This clinical trial studies the following conditions: Malignant Melanoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06961006?

The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Placebo (OTHER), V940 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06961006?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06961006 being conducted?

This trial has 20 study locations across Arkansas, California, New Jersey, Virginia, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial