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NCT00576875 · ClinicalTrials.gov registry record
Duke Conte Center for the Neuroscience of Depression in Late Life
A clinical trial of Major Depression, sponsored by Duke University.
- Completed
- Registry status
- 795
- Enrollment target
- 1
- Study location
NCT00576875: Completed study of Major Depression, sponsored by Duke University.
NCT00576875 is a study of Major Depression that has completed, run by Duke University. The registered enrollment target is 795 participants, above the 299-participant average among 28 other Major Depression trials with a reported enrollment target (166% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00576875, a study of Major Depression, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- 795 participants
- Enrollment target
- 1
- Study location
Study Summary
The proposed Silvio O. Conte Center for Neuroscience of Depression will focus on understanding the neurobiological mechanism of depression. A total of 5 projects are proposed. The center is focused on a single hypothesis. The first project examines localization of lesions, structural changes in critical regions subserving the circuit, alterations in the white matter tracts relevant to the circuit and changes in glutamate. The second project uses post mortem cell counting and cellular localization in serotonin receptors and assessment of the type of cell loss in the orbitofrontal cortex. The third project uses cognitive paradigms and functional MRI to probe the circuit and the role of brain lesions and serotonin on the functioning of this circuit. The fourth project uses transgenic and knockout mice to examine to role of norepinephrine and serotonin as it relates to the circuit. The final project is designed to assess in these transgenic mice using multielectrode array of single neuron recordings of the firing pattern of the circuit neurons in various states and tasks and the role of monoamines in modulating this circuit.
Conditions Studied
Study Locations (1)
North Carolina
- Duke University Medical Center - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 795 participants |
| Start Date | 2006-08 |
| Est. Completion | 2011-07 |
What the finished NCT00576875 record still lists
NCT00576875 is an observational study that tracks outcomes without assigning an intervention. The registered 795 participants enrollment target is mid-sized for trials with a published cap, above the 299-participant average among 28 other Major Depression trials with a reported enrollment target (166% higher).
The record links to 1 condition, with Major Depression appearing as the primary indexed condition, and to 0 interventions.
NCT00576875 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT00576875 about?
NCT00576875 is a clinical study titled "Duke Conte Center for the Neuroscience of Depression in Late Life". The proposed Silvio O. Conte Center for Neuroscience of Depression will focus on understanding the neurobiological mechanism of depression. A total of 5 projects are proposed. The center is focused on a single hypothesis. The first project examines localization of lesions, structural changes in crit...
What is the current status of trial NCT00576875?
This trial is currently completed. The enrollment target is 795 participants. The study started on 2006-08. Estimated completion is 2011-07.
What conditions does trial NCT00576875 study?
This clinical trial studies the following conditions: Major Depression.
Who is sponsoring clinical trial NCT00576875?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00576875 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00576875's enrollment target sits among peer trials
795 5th of 28 higher than 24 of 28 other Major Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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