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NCT02434393 · ClinicalTrials.gov registry record

Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project

A clinical trial of Major Depression and Late Life Depression (LLD), sponsored by University of Southern California.

Recruiting
Registry status
120
Enrollment target
2
Study locations

NCT02434393 is a study of Major Depression and Late Life Depression (LLD) that is actively recruiting participants, run by University of Southern California. The registered enrollment target is 120 participants, below the 323-participant average among 28 other Major Depression trials with a reported enrollment target (63% lower). The trial reports 2 study locations across 2 states.

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The verdict

NCT02434393, a study of Major Depression and Late Life Depression (LLD), is actively recruiting participants, sponsored by University of Southern California.

RECRUITING
Registry status
120 participants
Enrollment target
2
Study locations

Study Summary

The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. From the originally enrolled participants, the continuation of the ADNI-D study will enroll 120 participants which will include following participants from the original (parent) protocol and enrollment of new participants for a period of 30 months. Data from an additional 300 non-depressed subjects will be used from ADNI studies for comparison. Depression history, symptom severity and health information will be collected at the initial visit to determine eligibility. An magnetic resonance imaging (MRI) scan, as well as amyloid (florbetapir) and tau (flortaucipr) positron emission tomography (PET) imaging will be conducted at San Francisco VA. Collection of plasma and serum for biomarkers, clinical assessments and cognitive assessments will be conducted at two time points. Blood samples will also be collected for genetic analysis.

Conditions Studied

Major Depression Late Life Depression (LLD)

Study Locations (2)

California

  • University of California, San Francisco - San Francisco

Pennsylvania

  • University of Pittsburgh - Pittsburgh

Trial Details

FieldValue
Enrollment Target 120 participants
Start Date 2015-03-04
Est. Completion 2027-05

Sponsor

University of Southern California

617 total trials

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What the Registry Record Tells You About NCT02434393

The ClinicalTrials.gov registry entry for NCT02434393 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 323-participant average among 28 other Major Depression trials with a reported enrollment target (63% lower). The listed sponsor is University of Southern California, which has 617 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Major Depression appearing as the primary indexed condition, and to 0 interventions.

NCT02434393 reports 2 study locations spanning 2 distinct geographic areas - top geographies include California, Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT02434393 about?

NCT02434393 is a clinical study titled "Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project". The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. From ...

What is the current status of trial NCT02434393?

This trial is currently recruiting. The enrollment target is 120 participants. The study started on 2015-03-04. Estimated completion is 2027-05.

What conditions does trial NCT02434393 study?

This clinical trial studies the following conditions: Major Depression, Late Life Depression (LLD).

Who is sponsoring clinical trial NCT02434393?

This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT02434393 being conducted?

This trial has 2 study locations across California, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.