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NCT02434393 · ClinicalTrials.gov registry record
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
A clinical trial of Major Depression and Late Life Depression (LLD), sponsored by University of Southern California.
- Recruiting
- Registry status
- 120
- Enrollment target
- 2
- Study locations
NCT02434393: Recruiting study of Major Depression and Late Life Depression (LLD), sponsored by University of Southern California.
NCT02434393 is a study of Major Depression and Late Life Depression (LLD) that is actively recruiting participants, run by University of Southern California. The registered enrollment target is 120 participants, below the 323-participant average among 28 other Major Depression trials with a reported enrollment target (63% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02434393, a study of Major Depression and Late Life Depression (LLD), is actively recruiting participants, sponsored by University of Southern California.
- RECRUITING
- Registry status
- 120 participants
- Enrollment target
- 2
- Study locations
Study Summary
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. From the originally enrolled participants, the continuation of the ADNI-D study will enroll 120 participants which will include following participants from the original (parent) protocol and enrollment of new participants for a period of 30 months. Data from an additional 300 non-depressed subjects will be used from ADNI studies for comparison. Depression history, symptom severity and health information will be collected at the initial visit to determine eligibility. An magnetic resonance imaging (MRI) scan, as well as amyloid (florbetapir) and tau (flortaucipr) positron emission tomography (PET) imaging will be conducted at San Francisco VA. Collection of plasma and serum for biomarkers, clinical assessments and cognitive assessments will be conducted at two time points. Blood samples will also be collected for genetic analysis.
Primary Outcome
The Digit Symbol subtest is a measure of attention, working memory, and information processing speed. Participants are presented with a stimulus sheet, and asked to write in the correct symbol that corresponds with a number keyed at the top of the page. A scaled score is calculated based on the number of total correct responses.
Conditions Studied
Study Locations (2)
California
- University of California, San Francisco - San Francisco
Pennsylvania
- University of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2015-03-04 |
| Est. Completion | 2027-05 |
What NCT02434393 shows while recruiting
NCT02434393 is an observational study that tracks outcomes without assigning an intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 323-participant average among 28 other Major Depression trials with a reported enrollment target (63% lower).
The record links to 2 conditions, with Major Depression appearing as the primary indexed condition, and to 0 interventions.
NCT02434393 reports a single indexed study location in California, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT02434393 about?
NCT02434393 is a clinical study titled "Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project". The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. From ...
What is the current status of trial NCT02434393?
This trial is currently recruiting. The enrollment target is 120 participants. The study started on 2015-03-04. Estimated completion is 2027-05.
What conditions does trial NCT02434393 study?
This clinical trial studies the following conditions: Major Depression, Late Life Depression (LLD).
Who is sponsoring clinical trial NCT02434393?
This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02434393 being conducted?
This trial has 2 study locations across California, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02434393's enrollment target sits among peer trials
120 14th of 28 higher than 15 of 28 other Major Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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