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Irritable Bowel Syndrome: early-phase trial registry
14 of 49 indexed Irritable Bowel Syndrome trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #281 of 28,707 conditions by registered trial count.
49 US clinical trials · 14 currently recruiting · #281 of 28,707 conditions by registered trial count
Irritable Bowel Syndrome: 49 US clinical trials tracked, 14 recruiting.
Irritable Bowel Syndrome is the subject of 49 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is Mayo Clinic, running 4 of these trials.
Enrollment posture brief
Registry condition irritable-bowel-syndrome
OPEN 14 | RECR 29% | LATE 2 | EARLY 12 | RANK #281 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Acne Scars (29% recruiting · 7 trials)
Irritable Bowel Syndrome lists 14 open slots (29% of 49 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Irritable Bowel Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Irritable Bowel Syndrome is recruiting below its size-band peers.
14 of 49 indexed trials (28.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Irritable Bowel Syndrome trials is spread across many organizations.
Mayo Clinic accounts for 4 of 49 trials (8.2%). 41 distinct sponsors appear on at least one study for this condition label.
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Typical Irritable Bowel Syndrome enrolment sits around 89 participants.
Median target enrolment is 89 among the 48 trials that report a genuine target (sentinel values excluded). 27 of those (56.3%) plan for fewer than 100 participants.
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Irritable Bowel Syndrome research is mostly interventional.
41 interventional and 8 observational studies make up this index (83.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
49 total, page 1 of 1
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
Brown University
NCT05754190
Online Social Learning Program for Parents With Irritable Bowel Syndrome: Raising Resilient Children
Seattle Children's Hospital
NCT05730491
Do Biomarkers Predict Response to a Pediatric Chronic Pain Symptom Management Program?
Baylor College of Medicine
NCT03823742
IBS Skin Patch Test Food Allergy Study
IBS-80
NCT06288672
Drug Interaction Potential of Pro-Inflammatory Conditions
Indiana University
NCT07360938
Mucosal and Microbiota Changes During Acute Campylobacteriosis
Mayo Clinic
NCT03223077
Psyllium in Pediatric IBS
Dr Bruno Chumpitazi, M.D.
NCT06639984
Visible Abdominal Distension
Hospital Universitari Vall d'Hebron Research Institute
NCT06369753
Study to Explore the Therapeutic Effect of Eluxadoline in Treating Irritable Bowel Syndrome With Diarrhea in Children
AbbVie
NCT03339128
Mechanisms of Gulf War Illness
VA Office of Research and Development
NCT05972291
Well-being in IBS: Strengths and Happiness (WISH) 2.0
Massachusetts General Hospital
NCT06866106
Fecal Microbiota Transplantation for IBS
Madhusudan (Madhu) Grover, MBBS
NCT05776914
GI Alpha-Gal Study
University of North Carolina, Chapel Hill
NCT06268717
Standardized Yoga & Meditation Program for Stress Reduction for Adolescents With Irritable Bowel Syndrome
The Cooper Health System
NCT05719246
Cerebral Cortical Influences on Autonomic Function
David Levinthal
NCT03869372
Pilot Study of the Physiological Effects of an Integrative Medicine Approach in Irritable Bowel Syndrome
Thomas Jefferson University
NCT03370614
Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS)
TRYP Therapeutics
NCT06206265
LOTRONEX® in Severe Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
Prometheus Laboratories
NCT01257477
Efficacy and Safety of IBS Digital Behavioral Treatment
metaMe Health
NCT04133519
A Multi-Center Trial to Determine the Safety and Efficacy of LX1033 in Subjects With Diarrhea-Predominant Irritable Bowel Syndrome
Lexicon Pharmaceuticals
NCT01494233
Effects of Open-label vs Double-blind Treatment in IBS
Beth Israel Deaconess Medical Center
NCT02802241
Treatment of Functional Bowel Disorders
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00006157
Acupuncture for Irritable Bowel Syndrome
National Center for Complementary and Integrative Health (NCCIH)
NCT00065403
A Study of Crofelemer to Treat Diarrhea Irritable Bowel Syndrome
Bausch Health Americas
NCT00101725
Development of a Questionnaire to Measure Hypervigilance for Visceral Pain
University of North Carolina, Chapel Hill
NCT01166802
Efficacy, Safety and Tolerability of DNK333 (25 and 100 mg Bid) in Women With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
Novartis
NCT00699166
Basket Study (CT-100-002) to Evaluate the Effects of a DiNaMo™ Component Training
Click Therapeutics
NCT05573685
Neuroimaging and Biomarkers in Chronic Visceral Pain
University of California, Los Angeles
NCT01602575
Effect of BIO-K+ on Symptoms of Irritable Bowel Syndrome
Bio-K Plus International
NCT01545037
Nursing Management of Irritable Bowel Syndrome (IBS) 2008
University of Washington
NCT00907790
Irritable Bowel Syndrome Hypnotherapy
Mind-Body Digestive Center
NCT01248013
Precision Pain Self-Management in Young Adults With Irritable Bowel Syndrome
University of Connecticut
NCT03332537
A Longitudinal Study to Identify IBS Phenotypes Using Fecal Microbiota and Hydrogen Breath Testing
University of Michigan
NCT03219528
Harnessing Placebo Effects: Non-Deceptive Use of Placebo in Irritable Bowel Syndrome (IBS)
Harvard University Faculty of Medicine
NCT01010191
A Placebo-Controlled Trial of St. John's Wort for Irritable Bowel Syndrome
Mayo Clinic
NCT00587860
Mindfulness-Based Stress Reduction and the Microbiome
Seattle Institute for Biomedical and Clinical Research
NCT01619384
Gulf War Digestive Health Study
US Department of Veterans Affairs
NCT00680836
Integrative Approaches to Managing Irritable Bowel Syndrome (IBS)
Beth Israel Medical Center
NCT02436603
Audio-recorded Gut-Hypnotherapy for Sleep and Pain in Pediatric Abdominal Pain Disorders
Children's Hospital at Montefiore
NCT07216092
Delivered Dietary Intervention for Children With Irritable Bowel Syndrome
Baylor College of Medicine
NCT01339117
Effect of TU-100 in Patients With Irritable Bowel Syndrome (IBS)
Tsumura U
NCT01890837
Gut Permeability, Sensitivity and Symptomatology
Mayo Clinic
NCT02358564
Biomarkers for Intestinal Permeability in Patients With Constipation
Mayo Clinic
NCT02246647
AcuGraph and Digestive Symptoms
Logan College of Chiropractic
NCT00846794
Effect of Repetitive Transcranial Direct Current Stimulation (tDCS) on Chronic Pelvic Pain
Summa Health System
NCT00554320
Diet Reintroduction Study in Irritable Bowel Syndrome
University of Michigan
NCT03052439
SBI in Children With d-IBS
Louisiana State University Health Sciences Center in New Orleans
NCT02609529
Pilot Study Using a Dietary Intervention for Children With Irritable Bowel Syndrome
Baylor College of Medicine
NCT01018498
Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome
US Department of Veterans Affairs
NCT00108446
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 10 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Irritable Bowel Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Irritable Bowel Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Irritable Bowel Syndrome page
49 registered trials, 14 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 14 Irritable Bowel Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Mayo Clinic sponsors the most Irritable Bowel Syndrome trials on record, review their full trial history before evaluating a specific study. See Mayo Clinic's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Irritable Bowel Syndrome condition card totals 49 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.