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ClinicalTrials.gov 62 recruiting now full pipeline #74 of 28,707 conditions

Insomnia: full-pipeline trial registry

62 of 152 indexed Insomnia trials are currently recruiting.

Corpus placement: #74 of 28,707 conditions by registered trial count.

152 US clinical trials · 62 currently recruiting · #74 of 28,707 conditions by registered trial count

Insomnia: 152 US clinical trials tracked, 62 recruiting.

Insomnia is the subject of 152 registered US clinical trials on ClinicalTrials.gov, 62 of them currently open to new participants. 17 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 9 of these trials.

Enrollment posture brief

Registry condition insomnia

OPEN 62 | RECR 41% | LATE 17 | EARLY 21 | RANK #74 | SPON 9

Nearest open-share peer: Brain Injuries, Traumatic (41% recruiting · 22 trials)

Cervical Cancer48.3%Sleep48%Stress41.8%Insomnia (this)41%Atopic Dermatitis36.4%
Open-enrollment share among volume-matched conditions near Insomnia

Insomnia lists 62 open slots (41% of 152 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Insomnia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Insomnia is recruiting above its size-band peers.

    62 of 152 indexed trials (40.8%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Insomnia trials is spread across many organizations.

    VA Office of Research and Development accounts for 9 of 152 trials (5.9%). 86 distinct sponsors appear on at least one study for this condition label.

  3. Typical Insomnia enrolment sits around 80 participants.

    Median target enrolment is 80 among the 152 trials that report a genuine target (sentinel values excluded). 85 of those (55.9%) plan for fewer than 100 participants.

  4. Insomnia research is mostly interventional.

    147 interventional and 5 observational studies make up this index (96.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 15Phase 216Phase 35Phase 412

Open and recent trials

152 total, page 2 of 4

RECRUITING NA 50 participants

Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients

Massachusetts General Hospital

NCT06375265

RECRUITING NA 40 participants

Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic Leukemia

St. Jude Children's Research Hospital

NCT07191119

RECRUITING NA 40 participants

Digital Cognitive Behavioral Treatment of Insomnia in Youth: An RCT Examining Feasibility, Acceptability, and Efficacy of NiteCAPP Jr

University of South Florida

NCT07091149

RECRUITING NA 40 participants

Assessing the Feasibility of Web-based Insomnia Treatment Among Prostate Cancer Survivors

Georgetown University

NCT07128927

RECRUITING 40 participants

Implementation & Dissemination of a Digital Health Intervention for Adolescent Sleep

University of Kansas Medical Center

NCT06840444

RECRUITING Phase 1 30 participants

Mindfulness Meditation for Insomnia

Brigham and Women's Hospital

NCT06972303

RECRUITING NA 30 participants

Treating Insomnia in Mild Cognitive Impairment

Beth Israel Deaconess Medical Center

NCT06687161

RECRUITING NA 28 participants

Adapted CBT-I for Adolescents With Insomnia : The DREAM-IT Study

Indiana University

NCT06541886

RECRUITING NA 25 participants

Forehead Temperature-Regulating Therapy for Insomnia in Adults With Tourette's Disorder

University of California, Los Angeles

NCT05499741

RECRUITING NA 15 participants

Novel Adaptive Cognitive Training in Autistic Adults with Co-occurring Insomnia

University of South Florida

NCT06291298

RECRUITING Early Phase 1 15 participants

CBTi for the Treatment of Insomnia in Type 1 Diabetes

University of Illinois at Chicago

NCT07091318

RECRUITING NA 10 participants

LiverSleep: A Behavioral Sleep Intervention for Patients With Cirrhosis and Insomnia

Massachusetts General Hospital

NCT07417163

ACTIVE NOT RECRUITING NA 1,000 participants

The Assessment of Human Sleep and Its Functions

StimScience

NCT07211646

ACTIVE NOT RECRUITING Phase 3 673 participants

National Adaptive Trial for PTSD Related Insomnia

VA Office of Research and Development

NCT03668041

ACTIVE NOT RECRUITING NA 456 participants

Perinatal Research on Improving Sleep and Mental Health

University of California, San Francisco

NCT05596318

ACTIVE NOT RECRUITING NA 240 participants

Remote STATE Training for Insomnia in Older Adults

Posit Science Corporation

NCT06589024

ACTIVE NOT RECRUITING NA 224 participants

Intervention for Sleep and Pain in Youth: a Randomized Controlled Trial

Seattle Children's Hospital

NCT04936321

ACTIVE NOT RECRUITING Phase 4 200 participants

Evaluation of a Neurostimulation Device for Insomnia: A Randomized Trial

ProofPilot

NCT04627480

ACTIVE NOT RECRUITING NA 152 participants

CBT-I to Improve Functional Outcomes in Veterans With Psychosis

VA Office of Research and Development

NCT04646200

ACTIVE NOT RECRUITING NA 134 participants

Targeting Sleep Homeostasis to Improve Alcohol Use Disorder Treatment Outcomes (M-STAR Study)

University of Michigan

NCT04457674

ACTIVE NOT RECRUITING NA 100 participants

Improving Negative Stressful Perseverations in Insomnia to Revitalize Expecting Moms (INSPIRE)

Henry Ford Health System

NCT05356364

ACTIVE NOT RECRUITING Phase 2 98 participants

Effects of Mirtazapine on Appetite in Advanced Cancer Patients

M.D. Anderson Cancer Center

NCT00488072

ACTIVE NOT RECRUITING NA 80 participants

Neurotechnology Following Traumatic Brain Injury

Brain State Technologies

NCT03649958

ACTIVE NOT RECRUITING Phase 4 60 participants

Solriamfetol and CBT-I in Patients With Insomnia Disorder

University of Pennsylvania

NCT05838430

ACTIVE NOT RECRUITING NA 60 participants

A Conversational Agent (Cecebot) to Improve Insomnia in Stage I-III Breast Cancer Survivors

University of Washington

NCT06392789

ACTIVE NOT RECRUITING NA 60 participants

Improving Sleep With a Digital Cognitive Behavioral Therapy for Insomnia Application

Brigham and Women's Hospital

NCT05991492

ACTIVE NOT RECRUITING 50 participants

Partial Sleep Restriction in Chronic Low Back Pain: A Feasibility Study

University of Kansas Medical Center

NCT07008924

ACTIVE NOT RECRUITING NA 42 participants

Comparing Virtual Yoga to Standard Care on Insomnia Among Cancer Survivors

University of Rochester

NCT04458194

ACTIVE NOT RECRUITING NA 14 participants

Nexalin Therapy as a Viable Adjunctive Treatment for Substance Use Disorders

University of Arizona

NCT03540745

COMPLETED NA 1,836 participants

Sustainable Methods, Algorithms, and Research Tools for Delivering Optimal Care Study

Stanford University

NCT02037438

COMPLETED NA 746 participants

Yoga, Survivorship Health Education, and Cognitive Behavioral Therapy in Reducing Insomnia in Cancer Survivors

University of Rochester NCORP Research Base

NCT02613364

COMPLETED Phase 3 545 participants

A Study of Eszopiclone in Subjects With Insomnia Related to Major Depressive Disorder

Sumitomo Pharma America

NCT00368030

COMPLETED NA 542 participants

Hypertension With Unsatisfactory Sleep Health

University of Pittsburgh

NCT02508129

COMPLETED Phase 4 420 participants

Safety and Efficacy of Eszopiclone in Patients With Generalized Anxiety Disorder

Sumitomo Pharma America

NCT00235508

COMPLETED Phase 2 342 participants

Effects Of GW679769 On Sleep Onset And Maintenance And Next Day Functioning In Subjects With Primary Insomnia

GlaxoSmithKline

NCT00280423

COMPLETED NA 333 participants

Reducing Health Disparities for Black Women in the Treatment of Insomnia

Boston University

NCT03613519

COMPLETED NA 311 participants

Sleep Healthy Using The Internet for Older Adult Sufferers of Insomnia and Sleeplessness

University of Virginia

NCT03213132

COMPLETED Phase 3 304 participants

Long Term Safety Study of Study Drug (Eszopiclone) in Children and Adolescents With ADHD -Associated Insomnia

Sumitomo Pharma America

NCT00857220

COMPLETED 250 participants

Evaluation of the Reliability and Validity of a Diagnostic Sleep Disorders Questionnaire

Dayzz Live Well

NCT03468400

COMPLETED NA 208 participants

Research on Expecting Moms and Sleep Therapy

University of California, San Francisco

NCT02805998

COMPLETED Phase 4 197 participants

Partial Reinforcement II: Three Approaches to Maintenance Therapy for Chronic Insomnia

University of Pennsylvania

NCT03774810

COMPLETED NA 180 participants

Impact of Sleep Workshops in College Students

NYU Langone Health

NCT02665247

COMPLETED Phase 2 173 participants

Safety and Efficacy Study of APD125 in Patient With Insomnia

Arena Pharmaceuticals

NCT00452179

COMPLETED NA 167 participants

Preventing Insomnia With Virtual Oneshot Therapy (PIVOT)

Henry Ford Health System

NCT05523726

COMPLETED NA 160 participants

Choosing Options for Insomnia in Cancer Effectively (CHOICE): A Comparative Effectiveness Trial of Acupuncture and Cognitive Behavior Therapy

Memorial Sloan Kettering Cancer Center

NCT02356575

COMPLETED NA 128 participants

Treatments for Insomnia: Mediators, Moderators and Quality of Life

Palo Alto Veterans Institute for Research

NCT02117388

COMPLETED Phase 3 126 participants

Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis

University of Washington

NCT03534284

COMPLETED NA 114 participants

Dual Treatment of Chronic Pain and Insomnia

Mary Free Bed Rehabilitation Hospital

NCT05033418

COMPLETED Phase 4 108 participants

Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes

Massachusetts General Hospital

NCT03818581

COMPLETED NA 102 participants

Optimizing Efficiency and Impact of Digital Health Interventions for Caregivers

University of Virginia

NCT04986904

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Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 16
Phase 3 5
Phase 4 12

Named interventions

Most-linked intervention names on Insomnia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Drug
10 trials
Placebo Other
8 trials
Cognitive Behavioral Therapy for Insomnia Behavioral
7 trials
CBT-I Behavioral
5 trials
Suvorexant Drug
5 trials
Cognitive Behavioral Therapy for Insomnia (CBT-I) Behavioral
5 trials
Eszopiclone Drug
4 trials
Trazodone Drug
4 trials

US sites by state

Facility locations filed on Insomnia trials. A trial with sites in several states counts in each.

California 25 trials
Massachusetts 22 trials
Pennsylvania 14 trials
Michigan 14 trials
New York 12 trials
Florida 12 trials
Maryland 11 trials
North Carolina 9 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Insomnia page

152 registered trials, 62 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Insomnia condition card totals 152 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.