Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Hypoglycemia

Open-data reference.

42 US clinical trials · 15 currently recruiting

Active & Recent Trials

RECRUITING NA 15,732 participants

Diabetes Clinical Decision Support

Milton S. Hershey Medical Center

NCT05447806

RECRUITING 1,500 participants

Diagnosing and Treating Low Blood Sugar Levels

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00001276

RECRUITING NA 360 participants

Safer Aging With Diabetes Monitoring

Kaiser Permanente

NCT06296485

RECRUITING Early Phase 1 160 participants

Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery

The University of Texas Health Science Center at San Antonio

NCT00992901

RECRUITING NA 150 participants

Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes

University of Colorado, Denver

NCT06297980

RECRUITING NA 62 participants

Enhancing Shared Decision-making to Guide Care for People With Dementia and Diabetes

Indiana University

NCT05643144

RECRUITING Early Phase 1 38 participants

Effect of C-peptide on Hypoglycemic Counterregulation

University of Cincinnati

NCT06470295

RECRUITING Early Phase 1 32 participants

Differing Levels of Hypoglycemia

University of Maryland, Baltimore

NCT02445781

RECRUITING NA 30 participants

Monitoring Exhaled Breath to Noninvasively Detect Glycemic Events

Indiana University

NCT06893341

RECRUITING 20 participants

A Study of Glycemic Control in Left Ventricular Assist

Mayo Clinic

NCT05933161

RECRUITING Phase 1 13 participants

A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

Otsuka Pharmaceutical Factory

NCT06575426

RECRUITING NA 10 participants

Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes

University of Cincinnati

NCT05973799

RECRUITING NA 10 participants

Evaluating Glial Acetate Metabolism as a Biomarker of Hypoglycemic Counterregulation

Pennington Biomedical Research Center

NCT04207619

RECRUITING 10 participants

CGM-Assisted Management of PN

Boston Children's Hospital

NCT05902104

RECRUITING 5 participants

External Carotid Blood Flow in Individuals With Post-Bariatric Hypoglycemia

Joslin Diabetes Center

NCT07082478

ACTIVE NOT RECRUITING NA 218 participants

Continuous Glucose Monitoring Devices in Hospitalized Veterans With Diabetes

VA Office of Research and Development

NCT03508934

ACTIVE NOT RECRUITING NA 35 participants

Study of a Primary Care Hypoglycemia Prevention Program

Johns Hopkins University

NCT06353217

ACTIVE NOT RECRUITING 33 participants

Mechanisms of Hypoglycemia in Patients Without Diabetes

Joslin Diabetes Center

NCT04428723

ACTIVE NOT RECRUITING 28 participants

Hypoglycemia and the Gut Microbiome

Joslin Diabetes Center

NCT03385707

ACTIVE NOT RECRUITING Phase 4 28 participants

Glucagon Dose-Response in Patients With Post-Bariatric Hypoglycemia

Joslin Diabetes Center

NCT06986603

ACTIVE NOT RECRUITING Early Phase 1 11 participants

Adrenergic System in Islet Transplantation

University of Pennsylvania

NCT03079921

COMPLETED NA 568 participants

Identifying Driving Risk Factors in Type 1 Diabetes and Their Reduction Via Internet Program (DiabetesDriving.Com)

University of Virginia

NCT01563887

COMPLETED 200 participants

Carnitine Levels and Carnitine Supplementation in Type I Diabetes

Children's Mercy Hospital Kansas City

NCT00351234

COMPLETED NA 181 participants

Multi-Center Study Comparing Efficacy and Safety of Frequently Modified Insulin Therapy

Hygieia Research

NCT02424500

COMPLETED NA 168 participants

Technological Advances in Glucose Management in Older Adults

Joslin Diabetes Center

NCT03078491

COMPLETED 164 participants

Investigation Into the Effects Upon Brain Response to Change in Circulating Glucose Levels in Diabetes Mellitus

Yale University

NCT00580710

COMPLETED Phase 1 80 participants

GLP 1 for Intraoperative Glycemic Control

University of Pennsylvania

NCT00882492

COMPLETED NA 77 participants

Outcomes Study of MTM in a Medicare ACO

HealthEast Care System

NCT02875925

COMPLETED 62 participants

Comparison Between Pyloric Preserving and Non-Pyloric Preserving Bariatric Surgery With Glucose Challenge

Medtronic - MITG

NCT00998374

COMPLETED 58 participants

Hypoglycemia in Hospitalized Patients

University of Pittsburgh

NCT02228642

COMPLETED 57 participants

Hippocampal Metabolism and Function in Patients With Type 1 Diabetes

University of Minnesota

NCT01852968

COMPLETED Phase 3 42 participants

Trial to Confirm the Efficacy and Safety of Dasiglucagon in the Treatment of Hypoglycemia in T1DM Children

Zealand Pharma

NCT03667053

COMPLETED Phase 2 30 participants

Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of G-Pen(TM) (Glucagon Injection) to Treat Severe Hypoglycemia

Xeris Pharmaceuticals

NCT01972152

COMPLETED Phase 3 26 participants

Clinical Usability of Nasal Glucagon in Treatment of Hypoglycemia in Children and Adolescents

Eli Lilly and Company

NCT02402933

COMPLETED NA 21 participants

Hypoglycemia and the Mineralocorticoid Receptor

Brigham and Women's Hospital

NCT01394627

COMPLETED NA 14 participants

Hypoglycemia and Autonomic Nervous System Function- B2

Brigham and Women's Hospital

NCT03422471

COMPLETED NA 10 participants

Hybrid Closed Loop Insulin Delivery System in Hypoglycemia

University of Pennsylvania

NCT03215914

COMPLETED Phase 2 8 participants

Delivery of G-Pump™ (Glucagon Infusion) From an OmniPod® to Prevent Hypoglycemia in Post-Bariatric Surgery Patients

Xeris Pharmaceuticals

NCT02733588

COMPLETED Phase 2 7 participants

G-Pen™ for Hypoglycemia Rescue in T1D Patients

Xeris Pharmaceuticals

NCT02423980

COMPLETED Phase 1 6 participants

hOKT3γ1 (Ala-Ala) Combined With Sirolimus and Delayed Tacrolimus in Type 1 Diabetic Islet Allograft Recipients

University of Minnesota

NCT00285194

COMPLETED NA 3 participants

The Effect of Physical Activity in Individuals With Post-bariatric Hypoglycemia

Joslin Diabetes Center

NCT05560789

COMPLETED NA

Disorders of Systemic Glucose Balance

National Center for Research Resources (NCRR)

NCT00006508

Phase Distribution

PhaseTrial count
Early Phase 1 7
Phase 2 3
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hypoglycemia Trial Landscape

ClinicalTrials.gov lists 42 US studies indexed under Hypoglycemia, and 15 of those are currently open to recruitment — roughly 36% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Hypoglycemia shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 10 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Hypoglycemia is led by Joslin Diabetes Center with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 42 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hypoglycemia?

PlainTrial tracks 42 US clinical trials for Hypoglycemia, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hypoglycemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →