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Mechanisms of Hypoglycemia in Patients Without Diabetes
NCT04428723 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this study is to identify physiologic and molecular mechanisms that underlie hypoglycemia in the absence of diabetes (or medications that can cause hypoglycemia) and to investigate potential genetic and microbiome differences which contribute to hypoglycemia. We will test the hypothesis that hypoglycemia in the absence of diabetes is linked to genetic variation or the microbiome, and identify whether additional medical history or diagnoses are enriched in the population of patients with hypoglycemia.
Conditions Studied
Interventions
- GENETIC Blood sample for DNA analysis
- OTHER Entry of demographic and medical history data into a deidentified database
- DIAGNOSTIC_TEST Stool sample for microbiome analysis
- DIAGNOSTIC_TEST Mixed meal tolerance test
- DIAGNOSTIC_TEST Continuous glucose monitoring
Study Locations (1)
Massachusetts
- Joslin Diabetes Center — Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 33 participants |
| Start Date | 2020-08-11 |
| Est. Completion | 2026-12 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04428723
The ClinicalTrials.gov registry entry for NCT04428723 describes a study currently listed as active not recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 33 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Joslin Diabetes Center, which has 87 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Hypoglycemia appearing as the primary indexed condition, and to 5 interventions — of which Blood sample for DNA analysis is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04428723 reports 1 study location spanning 1 distinct geographic area — top geographies include Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04428723 about?
NCT04428723 is a clinical study titled "Mechanisms of Hypoglycemia in Patients Without Diabetes". The goal of this study is to identify physiologic and molecular mechanisms that underlie hypoglycemia in the absence of diabetes (or medications that can cause hypoglycemia) and to investigate potential genetic and microbiome differences which contribute to hypoglycemia. We will test the hypothesis ...
What is the current status of trial NCT04428723?
This trial is currently active not recruiting. The enrollment target is 33 participants. The study started on 2020-08-11. Estimated completion is 2026-12.
What conditions does trial NCT04428723 study?
This clinical trial studies the following conditions: Hypoglycemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04428723?
The interventions under investigation include: Blood sample for DNA analysis (GENETIC), Entry of demographic and medical history data into a deidentified database (OTHER), Stool sample for microbiome analysis (DIAGNOSTIC_TEST), Mixed meal tolerance test (DIAGNOSTIC_TEST), Continuous glucose monitoring (DIAGNOSTIC_TEST). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04428723?
This trial is sponsored by Joslin Diabetes Center, which has 87 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04428723 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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