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2026 data Public-data reference. official source

HPV Positive Oropharyngeal Squamous Cell Carcinoma

Open-data reference.

16 US clinical trials · 9 currently recruiting

Active & Recent Trials

RECRUITING Phase 2 145 participants

Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

Jonathan Schoenfeld, MD, MPH

NCT04900623

RECRUITING Phase 2 120 participants

Adaptive Treatment De-escalation in Favorable Risk HPV-Positive Oropharyngeal Carcinoma

NYU Langone Health

NCT03215719

RECRUITING 111 participants

De-escalated Radiation for Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx

University of California, Irvine

NCT05600842

RECRUITING Phase 1 98 participants

TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers

University of Chicago

NCT05108870

RECRUITING Phase 1 72 participants

A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer

Theravectys S.A.

NCT06319963

RECRUITING Phase 2 61 participants

Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)

University of Maryland, Baltimore

NCT06088381

RECRUITING Phase 2 30 participants

A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC)

Memorial Sloan Kettering Cancer Center

NCT05307939

RECRUITING Phase 2 28 participants

Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal Cancer

University of Missouri-Columbia

NCT04444869

RECRUITING Phase 1 15 participants

E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers

Christian Hinrichs

NCT05639972

ACTIVE NOT RECRUITING Phase 3 351 participants

Phase 3 Study of PDS0101 and Pembrolizumab in HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

PDS Biotechnology

NCT06790966

ACTIVE NOT RECRUITING NA 83 participants

Adjuvant Treatment Deintensification After Transoral Surgery for Human Papillomavirus-Positive Squamous Cell Carcinoma

Indiana University

NCT05119036

ACTIVE NOT RECRUITING Phase 2 40 participants

Trial of De-Intensified Post-operative Chemoradiation Following Robotic Surgery for HPV-positive Oropharyngeal Cancer

Cedars-Sinai Medical Center

NCT04502407

ACTIVE NOT RECRUITING 9 participants

A Study Using Human Papillomavirus (HPV) DNA Testing to Detect HPV-Related Oropharyngeal Cancer (OPC)

Memorial Sloan Kettering Cancer Center

NCT05814549

COMPLETED 103 participants

ctDNA Liquid Biopsy for Early Assessment of Residual Disease in HPV-associated Head and Neck Cancer (Clear-HPVca)

Massachusetts Eye and Ear Infirmary

NCT06730412

COMPLETED Phase 2 95 participants

Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC

PDS Biotechnology

NCT04260126

COMPLETED Phase 1 23 participants

Phase Ib Study of BKM120 With Cisplatin and XRT in High Risk Locally Advanced Squamous Cell Cancer of Head and Neck

Dana-Farber Cancer Institute

NCT02113878

Phase Distribution

PhaseTrial count
Early Phase 1 4
Phase 2 7
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the HPV Positive Oropharyngeal Squamous Cell Carcinoma Trial Landscape

ClinicalTrials.gov lists 16 US studies indexed under HPV Positive Oropharyngeal Squamous Cell Carcinoma, and 9 of those are currently open to recruitment — roughly 56% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for HPV Positive Oropharyngeal Squamous Cell Carcinoma shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 11 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for HPV Positive Oropharyngeal Squamous Cell Carcinoma is led by PDS Biotechnology with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 16 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for HPV Positive Oropharyngeal Squamous Cell Carcinoma?

PlainTrial tracks 16 US clinical trials for HPV Positive Oropharyngeal Squamous Cell Carcinoma, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for HPV Positive Oropharyngeal Squamous Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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