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ClinicalTrials.gov 10 recruiting now official registry

HPV Positive Oropharyngeal Squamous Cell Carcinoma clinical trials

10 of 17 indexed HPV Positive Oropharyngeal Squamous Cell Carcinoma trials are currently recruiting.

17 US clinical trials · 10 currently recruiting

HPV Positive Oropharyngeal Squamous Cell Carcinoma is the subject of 17 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is PDS Biotechnology, running 2 of these trials.

The research picture

HPV Positive Oropharyngeal Squamous Cell Carcinoma has 17 registered US clinical trials, 10 of them open to new participants right now, about 59% of the total.

10
recruiting participants now
59%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: PDS Biotechnology
Phase 14Phase 28Phase 31

Active & Recent Trials

17 total, page 1 of 1

RECRUITING Phase 2 145 participants

Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

Jonathan Schoenfeld, MD, MPH

NCT04900623

RECRUITING Phase 2 120 participants

Adaptive Treatment De-escalation in Favorable Risk HPV-Positive Oropharyngeal Carcinoma

NYU Langone Health

NCT03215719

RECRUITING 111 participants

De-escalated Radiation for Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx

University of California, Irvine

NCT05600842

RECRUITING Phase 1 98 participants

TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers

University of Chicago

NCT05108870

RECRUITING Phase 2 83 participants

The Sinai Robotic Surgery Trial in HPV-related Oropharyngeal Squamous Cell Carcinoma (SIRS 2.0 Trial)

Icahn School of Medicine at Mount Sinai

NCT05419089

RECRUITING Phase 1 72 participants

A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer

Theravectys S.A.

NCT06319963

RECRUITING Phase 2 61 participants

Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)

University of Maryland, Baltimore

NCT06088381

RECRUITING Phase 2 30 participants

A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC)

Memorial Sloan Kettering Cancer Center

NCT05307939

RECRUITING Phase 2 28 participants

Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal Cancer

University of Missouri-Columbia

NCT04444869

RECRUITING Phase 1 15 participants

E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers

Christian Hinrichs

NCT05639972

ACTIVE NOT RECRUITING Phase 3 351 participants

Phase 3 Study of PDS0101 and Pembrolizumab in HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

PDS Biotechnology

NCT06790966

ACTIVE NOT RECRUITING NA 83 participants

Adjuvant Treatment Deintensification After Transoral Surgery for Human Papillomavirus-Positive Squamous Cell Carcinoma

Indiana University

NCT05119036

ACTIVE NOT RECRUITING Phase 2 40 participants

Trial of De-Intensified Post-operative Chemoradiation Following Robotic Surgery for HPV-positive Oropharyngeal Cancer

Cedars-Sinai Medical Center

NCT04502407

ACTIVE NOT RECRUITING 9 participants

A Study Using Human Papillomavirus (HPV) DNA Testing to Detect HPV-Related Oropharyngeal Cancer (OPC)

Memorial Sloan Kettering Cancer Center

NCT05814549

COMPLETED 103 participants

ctDNA Liquid Biopsy for Early Assessment of Residual Disease in HPV-associated Head and Neck Cancer (Clear-HPVca)

Massachusetts Eye and Ear Infirmary

NCT06730412

COMPLETED Phase 2 95 participants

Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC

PDS Biotechnology

NCT04260126

COMPLETED Phase 1 23 participants

Phase Ib Study of BKM120 With Cisplatin and XRT in High Risk Locally Advanced Squamous Cell Cancer of Head and Neck

Dana-Farber Cancer Institute

NCT02113878

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 8
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the HPV Positive Oropharyngeal Squamous Cell Carcinoma Trial Landscape

17 indexed HPV Positive Oropharyngeal Squamous Cell Carcinoma studies · 10 recruiting (59%).

Phase mix: 1 late (III/IV) vs 12 early (I/II).

Top sponsor: PDS Biotechnology (2 trials), 9 others listed. 17 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for HPV Positive Oropharyngeal Squamous Cell Carcinoma?

PlainTrial tracks 17 US clinical trials for HPV Positive Oropharyngeal Squamous Cell Carcinoma, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for HPV Positive Oropharyngeal Squamous Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.