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NCT04414540 · ClinicalTrials.gov registry record · Phase 2

Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients

A Phase 2 study of Head and Neck Squamous Cell Carcinoma, sponsored by Trisha Wise-Draper.

Active
Registry status
Phase 2
Development phase
20
Enrollment target
1
Study location

NCT04414540 is a Phase 2 study of Head and Neck Squamous Cell Carcinoma that is active but no longer recruiting, run by Trisha Wise-Draper. The registered enrollment target is 20 participants, below the 117-participant average among 124 other Head and Neck Squamous Cell Carcinoma trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT04414540, a Phase 2 study of Head and Neck Squamous Cell Carcinoma, is active but no longer recruiting, sponsored by Trisha Wise-Draper.

ACTIVE NOT RECRUITING
Registry status
Phase 2
Development phase
20 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is to determine anti-tumor activity by measuring overall response rate in recurrent and/or metastatic HNSCC patients receiving the combination of metformin and pembrolizumab.

Conditions Studied

Head and Neck Squamous Cell Carcinoma

Interventions

  • DRUG Pembrolizumab
  • DRUG Metformin Extended Release Oral Tablet

Study Locations (1)

Ohio

  • University of Cincinnati Medical Center - Cincinnati

Trial Details

FieldValue
Enrollment Target 20 participants
Start Date 2020-08-31
Est. Completion 2025-12
Phase Phase 2

Sponsor

Trisha Wise-Draper

6 total trials

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What the Registry Record Tells You About NCT04414540

The ClinicalTrials.gov registry entry for NCT04414540 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 117-participant average among 124 other Head and Neck Squamous Cell Carcinoma trials with a reported enrollment target (83% lower). The listed sponsor is Trisha Wise-Draper, which has 6 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Head and Neck Squamous Cell Carcinoma appearing as the primary indexed condition, and to 2 interventions - of which Pembrolizumab is the first listed.

NCT04414540 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.

Frequently Asked Questions

What is clinical trial NCT04414540 about?

NCT04414540 is a clinical study titled "Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients". The purpose of this study is to determine anti-tumor activity by measuring overall response rate in recurrent and/or metastatic HNSCC patients receiving the combination of metformin and pembrolizumab.

What is the current status of trial NCT04414540?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2020-08-31. Estimated completion is 2025-12.

What conditions does trial NCT04414540 study?

This clinical trial studies the following conditions: Head and Neck Squamous Cell Carcinoma.

What interventions are being tested in trial NCT04414540?

The interventions under investigation include: Pembrolizumab (DRUG), Metformin Extended Release Oral Tablet (DRUG).

Who is sponsoring clinical trial NCT04414540?

This trial is sponsored by Trisha Wise-Draper, which has 6 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04414540 being conducted?

This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.