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ClinicalTrials.gov 10 recruiting now early-phase tilt small index

Executive Dysfunction: early-phase trial registry

10 of 18 indexed Executive Dysfunction trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #953 of 28,707 conditions by registered trial count.

18 US clinical trials · 10 currently recruiting · #953 of 28,707 conditions by registered trial count

Executive Dysfunction: 18 US clinical trials tracked, 10 recruiting.

Executive Dysfunction is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is St. Jude Children's Research Hospital, running 2 of these trials.

Enrollment posture brief

Registry condition executive-dysfunction

OPEN 10 | RECR 56% | LATE 1 | EARLY 2 | RANK #953 | SPON 2

Nearest open-share peer: Acute Lymphoblastic Leukemia, Pediatric (56% recruiting · 9 trials)

Executive Dysfunction (this)56%Arrhythmias, Cardiac27.8%Androgenetic Alopecia16.7%Anemia, Sickle Cell16.7%Acquired Immunodeficiency Sy5.6%
Open-enrollment share among volume-matched conditions near Executive Dysfunction

Executive Dysfunction lists 10 open slots (56% of 18 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Executive Dysfunction on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Executive Dysfunction is recruiting above its size-band peers.

    10 of 18 indexed trials (55.6%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Executive Dysfunction trials is spread across many organizations.

    St. Jude Children's Research Hospital accounts for 2 of 18 trials (11.1%). 16 distinct sponsors appear on at least one study for this condition label.

  3. Most Executive Dysfunction trials plan to enrol fewer than 100 people.

    Median target enrolment is 72 among the 18 trials that report a genuine target (sentinel values excluded). 11 of those (61.1%) plan for fewer than 100 participants.

  4. Executive Dysfunction research is mostly interventional.

    17 interventional and 1 observational studies make up this index (94.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 11Phase 21Phase 31

Open and recent trials

18 total, page 1 of 1

RECRUITING Phase 3 372 participants

Goal-Directed Sedation in Mechanically Ventilated Infants and Children

Vanderbilt University Medical Center

NCT04801589

RECRUITING NA 310 participants

Epilepsy Journey-An Executive Functioning Intervention for Teens With Epilepsy

Children's Hospital Medical Center, Cincinnati

NCT06608966

RECRUITING NA 240 participants

HOPS Study: A Conceptual Replication

Children's Hospital of Philadelphia

NCT04465708

RECRUITING NA 144 participants

Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia

Hebrew SeniorLife

NCT05661084

RECRUITING NA 100 participants

Randomized Controlled Trial of a Behavioral Training App

New York University

NCT06447909

RECRUITING Phase 1 72 participants

Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

St. Jude Children's Research Hospital

NCT07226219

RECRUITING Phase 2 70 participants

A Digital Intervention for Post-Stroke Depression and Executive Dysfunction

Weill Medical College of Cornell University

NCT05507138

RECRUITING NA 30 participants

Causal Role of the Aperiodic Signal for Working Memory

Florida State University

NCT06126809

RECRUITING NA 24 participants

Transcranial Direct Current Stimulation in Children With Autism

New York State Institute for Basic Research

NCT07092280

RECRUITING NA 20 participants

Engage for Late-Life Depression and Comorbid Executive Dysfunction

University of Nevada, Las Vegas

NCT05356611

ACTIVE NOT RECRUITING 600 participants

Acute Cognitive Changes During Atrial Fibrillation Episodes (AFCOG)

David Brunk, PA-C, MMS

NCT04033510

ACTIVE NOT RECRUITING NA 64 participants

Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD

Children's National Research Institute

NCT05131659

ACTIVE NOT RECRUITING NA 36 participants

Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)

St. Jude Children's Research Hospital

NCT04105530

COMPLETED NA 137 participants

Online Emotion Regulation Group Intervention

Icahn School of Medicine at Mount Sinai

NCT03479606

COMPLETED NA 75 participants

Adaptation and Implementation of an ASD Executive Functioning Intervention in Children's Mental Health Services

San Diego State University

NCT04295512

COMPLETED NA 30 participants

High-Speed Yoga and Executive Function

University of Miami

NCT04215900

COMPLETED NA 17 participants

Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women

University of Colorado, Denver

NCT02122198

COMPLETED NA 8 participants

Case Studies: Promoting Strategy Use in Functional Activities

Weill Medical College of Cornell University

NCT04363645

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 1
Phase 3 1

Named interventions

Most-linked intervention names on Executive Dysfunction records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Unstuck and on Target Behavioral
1 trials
Multicontext (MC) approach Other
1 trials
Medroxyprogesterone Drug
1 trials
High-speed yoga multi-directional yoga Behavioral
1 trials
Online Emotion Regulation Skills-training Behavioral
1 trials
Executive function group therapy Behavioral
1 trials
NIH Toolbox Flanker Inhibitory Control and Attention Test Other
1 trials
NIH Toolbox List Sorting Working Memory Test Other
1 trials

US sites by state

Facility locations filed on Executive Dysfunction trials. A trial with sites in several states counts in each.

New York 5 trials
Tennessee 3 trials
Florida 2 trials
Colorado 2 trials
California 2 trials
South Carolina 1 trials
Pennsylvania 1 trials
Ohio 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Executive Dysfunction page

18 registered trials, 10 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Executive Dysfunction condition card totals 18 registered trials; most-linked intervention Unstuck and on Target; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.