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ClinicalTrials.gov 9 recruiting now official registry

Essential Thrombocythemia clinical trials

Every US clinical trial registered for Essential Thrombocythemia — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

17 US clinical trials · 9 currently recruiting

The research picture

Essential Thrombocythemia has 17 registered US clinical trials, 9 of them open to new participants right now — about 53% of the total.

9
recruiting participants now
53%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
3
top sponsor: National Cancer Institute (NCI)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 3 340 participants

A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

Merck Sharp & Dohme

NCT06079879

RECRUITING Phase 3 300 participants

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

Merck Sharp & Dohme

NCT06456346

RECRUITING Phase 2 63 participants

Two Step Haplo With Radiation Conditioning

Thomas Jefferson University

NCT05031897

RECRUITING Phase 2 62 participants

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

National Cancer Institute (NCI)

NCT06661915

RECRUITING Phase 2 60 participants

Ruxolitinib in Thrombocythemia and Polycythemia Vera

Massachusetts General Hospital

NCT04644211

RECRUITING Phase 2 30 participants

Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms

University of Southern California

NCT06063486

RECRUITING Phase 1 27 participants

An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms

University of California, Irvine

NCT05123365

RECRUITING Phase 2 25 participants

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

University of Washington

NCT04282187

RECRUITING Phase 1 10 participants

Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm

Marina Kremyanskaya

NCT05025488

ACTIVE NOT RECRUITING Phase 3 174 participants

Ropeginterferon Alfa-2b (P1101) vs. Anagrelide in Essential Thrombocythemia Patients With Hydroxyurea Resistance or Intolerance

PharmaEssentia

NCT04285086

ACTIVE NOT RECRUITING Phase 2 91 participants

A Single-arm, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of P1101 in Adults With ET

PharmaEssentia

NCT05482971

ACTIVE NOT RECRUITING Phase 1 40 participants

Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT03862157

ACTIVE NOT RECRUITING Phase 2 25 participants

Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia

National Cancer Institute (NCI)

NCT03289910

ACTIVE NOT RECRUITING Phase 2 4 participants

IMG-7289 in Patients With Essential Thrombocythemia (ET) or Polycythemia Vera (PV)

Terrence J Bradley, MD

NCT04262141

COMPLETED Phase 1 100 participants

Study of LY2784544 Testing Alternative Dosing in Participants With Myeloproliferative Neoplasms

Eli Lilly and Company

NCT01520220

COMPLETED Phase 2 35 participants

Tipifarnib in Treating Patients With Myelofibrosis and Myeloid Metaplasia

National Cancer Institute (NCI)

NCT00047190

COMPLETED 17 participants

Familial Myeloproliferative Disorders

Icahn School of Medicine at Mount Sinai

NCT00666289

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 9
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Essential Thrombocythemia Trial Landscape

ClinicalTrials.gov lists 17 US studies indexed under Essential Thrombocythemia, and 9 of those are currently open to recruitment — roughly 53% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Essential Thrombocythemia shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 13 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Essential Thrombocythemia is led by National Cancer Institute (NCI) with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 17 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Essential Thrombocythemia?

PlainTrial tracks 17 US clinical trials for Essential Thrombocythemia, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Essential Thrombocythemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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