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ClinicalTrials.gov 9 recruiting now official registry

Essential Thrombocythemia clinical trials

9 of 17 indexed Essential Thrombocythemia trials are currently recruiting.

17 US clinical trials · 9 currently recruiting

Essential Thrombocythemia is the subject of 17 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 3 of these trials.

The research picture

Essential Thrombocythemia has 17 registered US clinical trials, 9 of them open to new participants right now, about 53% of the total.

9
recruiting participants now
53%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
3
top sponsor: National Cancer Institute (NCI)
Phase 14Phase 29Phase 33

Active & Recent Trials

17 total, page 1 of 1

RECRUITING Phase 3 340 participants

A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

Merck Sharp & Dohme

NCT06079879

RECRUITING Phase 3 300 participants

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

Merck Sharp & Dohme

NCT06456346

RECRUITING Phase 2 63 participants

Two Step Haplo With Radiation Conditioning

Thomas Jefferson University

NCT05031897

RECRUITING Phase 2 62 participants

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

National Cancer Institute (NCI)

NCT06661915

RECRUITING Phase 2 60 participants

Ruxolitinib in Thrombocythemia and Polycythemia Vera

Massachusetts General Hospital

NCT04644211

RECRUITING Phase 2 30 participants

Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms

University of Southern California

NCT06063486

RECRUITING Phase 1 27 participants

An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms

University of California, Irvine

NCT05123365

RECRUITING Phase 2 25 participants

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

University of Washington

NCT04282187

RECRUITING Phase 1 10 participants

Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm

Marina Kremyanskaya

NCT05025488

ACTIVE NOT RECRUITING Phase 3 174 participants

Ropeginterferon Alfa-2b (P1101) vs. Anagrelide in Essential Thrombocythemia Patients With Hydroxyurea Resistance or Intolerance

PharmaEssentia

NCT04285086

ACTIVE NOT RECRUITING Phase 2 91 participants

A Single-arm, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of P1101 in Adults With ET

PharmaEssentia

NCT05482971

ACTIVE NOT RECRUITING Phase 1 40 participants

Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT03862157

ACTIVE NOT RECRUITING Phase 2 25 participants

Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia

National Cancer Institute (NCI)

NCT03289910

ACTIVE NOT RECRUITING Phase 2 4 participants

IMG-7289 in Patients With Essential Thrombocythemia (ET) or Polycythemia Vera (PV)

Terrence J Bradley, MD

NCT04262141

COMPLETED Phase 1 100 participants

Study of LY2784544 Testing Alternative Dosing in Participants With Myeloproliferative Neoplasms

Eli Lilly and Company

NCT01520220

COMPLETED Phase 2 35 participants

Tipifarnib in Treating Patients With Myelofibrosis and Myeloid Metaplasia

National Cancer Institute (NCI)

NCT00047190

COMPLETED 17 participants

Familial Myeloproliferative Disorders

Icahn School of Medicine at Mount Sinai

NCT00666289

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 9
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Essential Thrombocythemia Trial Landscape

17 indexed Essential Thrombocythemia studies · 9 recruiting (53%).

Phase mix: 3 late (III/IV) vs 13 early (I/II).

Top sponsor: National Cancer Institute (NCI) (3 trials), 9 others listed. 17 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Essential Thrombocythemia?

PlainTrial tracks 17 US clinical trials for Essential Thrombocythemia, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Essential Thrombocythemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.