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RECRUITING Phase 3

A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

NCT06079879 · View on ClinicalTrials.gov ↗

Study Summary

This is a study evaluating the safety and efficacy of bomedemstat (MK-3543) compared with the best available therapy (BAT) in participants with essential thrombocythemia (ET) who have an inadequate response to or are intolerant of hydroxyurea. The primary study hypothesis is that bomedemstat is superior to the best available therapy with respect to durable clinicohematologic response (DCHR).

Conditions Studied

Interventions

  • DRUG Busulfan
  • DRUG Ruxolitinib
  • DRUG Bomedemstat
  • DRUG Anagrelide
  • DRUG Interferon alfa/pegylated interferon alfa 2a/pegylated interferon alfa 2b

Study Locations (20)

California

  • Los Angeles Cancer Network ( Site 3491) — Glendale
  • Stanford Cancer Institute ( Site 0107) — Stanford
  • The Lundquist Institute ( Site 3423) — Torrance

Michigan

  • University of Michigan ( Site 0008) — Ann Arbor
  • Henry Ford Hospital ( Site 3413) — Detroit

North Carolina

  • Duke University Health System (DUHS) ( Site 0016) — Durham
  • Wake Forest Baptist Health-Internal Medicine, Section on Hematology & Oncology ( Site 3400) — Winston-Salem

Virginia

  • University of Virginia ( Site 3422) — Charlottesville
  • VCU Health Adult Outpatient Pavillion ( Site 3416) — Richmond

New South Wales

  • Royal Prince Alfred Hospital ( Site 1100) — Camperdown
  • Liverpool Hospital-Haematology ( Site 0501) — Liverpool

Arizona

  • Palo Verde Hematology/ Oncology Center, Ltd. ( Site 3496) — Glendale

Colorado

  • University of Colorado Anschutz Medical Campus ( Site 3425) — Aurora

Massachusetts

  • Tufts Medical Center ( Site 3408) — Boston

Trial Details

FieldValue
Enrollment Target 340 participants
Start Date 2023-12-31
Est. Completion 2028-08-18
Phase Phase 3

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06079879

The ClinicalTrials.gov registry entry for NCT06079879 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 340 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Essential Thrombocythemia appearing as the primary indexed condition, and to 5 interventions — of which Busulfan is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06079879 reports 20 study locations spanning 14 distinct geographic areas — top geographies include California, Michigan, North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06079879 about?

NCT06079879 is a clinical study titled "A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)". This is a study evaluating the safety and efficacy of bomedemstat (MK-3543) compared with the best available therapy (BAT) in participants with essential thrombocythemia (ET) who have an inadequate response to or are intolerant of hydroxyurea. The primary study hypothesis is that bomedemstat is supe...

What is the current status of trial NCT06079879?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 340 participants. The study started on 2023-12-31. Estimated completion is 2028-08-18.

What conditions does trial NCT06079879 study?

This clinical trial studies the following conditions: Essential Thrombocythemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06079879?

The interventions under investigation include: Busulfan (DRUG), Ruxolitinib (DRUG), Bomedemstat (DRUG), Anagrelide (DRUG), Interferon alfa/pegylated interferon alfa 2a/pegylated interferon alfa 2b (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06079879?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06079879 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial