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ClinicalTrials.gov 5 recruiting now official registry

Eosinophilic Esophagitis (EoE) clinical trials

5 of 11 indexed Eosinophilic Esophagitis (EoE) trials are currently recruiting.

11 US clinical trials · 5 currently recruiting

Eosinophilic Esophagitis (EoE) is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Regeneron Pharmaceuticals, running 3 of these trials.

The research picture

Eosinophilic Esophagitis (EoE) has 11 registered US clinical trials, 5 of them open to new participants right now, about 45% of the total.

5
recruiting participants now
45%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
3
top sponsor: Regeneron Pharmaceuticals
Phase 23Phase 33Phase 41

Active & Recent Trials

11 total, page 1 of 1

RECRUITING 350 participants

A U.S. Registry of Eosinophilic Esophagitis Pediatric, Adolescent and Adult Patients Treated With DUPIXENT® As Standard of Care

Regeneron Pharmaceuticals

NCT06693531

RECRUITING 75 participants

Esophageal String Test Monitoring to Monitor Eosinophilic Esophagitis During Oral Immunotherapy

Children's Hospital of Philadelphia

NCT06389994

RECRUITING 30 participants

Surface EMG Testing on Swallowing in EoE Patients

Mayo Clinic

NCT07156357

RECRUITING Phase 4 30 participants

Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE)

University of California, San Diego

NCT06665971

RECRUITING Phase 3 20 participants

A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis

Regeneron Pharmaceuticals

NCT07112378

ACTIVE NOT RECRUITING Phase 2 184 participants

A Study to Investigate the Efficacy and Safety of NSI-8226 in Adults With Eosinophilic Esophagitis

Uniquity One (UNI)

NCT06598462

COMPLETED Phase 3 219 participants

An Extension Study to Evaluate Maintenance of Efficacy and Long-term Treatment Effect of Oral Budesonide Suspension (OBS) in Adults and Adolescents With Eosinophilic Esophagitis (EoE)

Shire

NCT02736409

COMPLETED Phase 2 129 participants

SOFEED: Six Food vs. One Food Eosinophilic Esophagitis Diet Study

Children's Hospital Medical Center, Cincinnati

NCT02778867

COMPLETED Phase 3 102 participants

Study to Investigate the Efficacy and Safety of Dupilumab in Pediatric Patients With Active Eosinophilic Esophagitis (EoE)

Regeneron Pharmaceuticals

NCT04394351

COMPLETED Phase 2 93 participants

OBS in Adolescent and Adults With EOE: A Phase II, Randomized, Double-Blind, Placebo Controlled, Study With an Open Label Extension

Shire

NCT01642212

COMPLETED 31 participants

Eating With Eosinophilic Esophagitis (EoE)

Mayo Clinic

NCT03581838

Phase Distribution

PhaseTrial count
Phase 2 3
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Eosinophilic Esophagitis (EoE) Trial Landscape

11 indexed Eosinophilic Esophagitis (EoE) studies · 5 recruiting (45%).

Phase mix: 4 late (III/IV) vs 3 early (I/II).

Top sponsor: Regeneron Pharmaceuticals (3 trials), 6 others listed. 11 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Eosinophilic Esophagitis (EoE)?

PlainTrial tracks 11 US clinical trials for Eosinophilic Esophagitis (EoE), of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Eosinophilic Esophagitis (EoE)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.