Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Down Syndrome: early-phase trial registry
21 of 55 indexed Down Syndrome trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #254 of 28,707 conditions by registered trial count.
55 US clinical trials · 21 currently recruiting · #254 of 28,707 conditions by registered trial count
Down Syndrome: 55 US clinical trials tracked, 21 recruiting.
Down Syndrome is the subject of 55 registered US clinical trials on ClinicalTrials.gov, 21 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is Sequenom, running 3 of these trials.
Enrollment posture brief
Registry condition down-syndrome
OPEN 21 | RECR 38% | LATE 5 | EARLY 10 | RANK #254 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Liver Diseases (38% recruiting · 34 trials)
Down Syndrome lists 21 open slots (38% of 55 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Down Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Down Syndrome recruits in line with its size-band peers.
21 of 55 indexed trials (38.2%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Down Syndrome trials is spread across many organizations.
Sequenom accounts for 3 of 55 trials (5.5%). 41 distinct sponsors appear on at least one study for this condition label.
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Typical Down Syndrome enrolment sits around 81 participants.
Median target enrolment is 81 among the 55 trials that report a genuine target (sentinel values excluded). 31 of those (56.4%) plan for fewer than 100 participants.
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Down Syndrome research is mostly interventional.
39 interventional and 16 observational studies make up this index (70.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
55 total, page 2 of 2
Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome
Wake Forest University Health Sciences
NCT03135236
Treatment Trial of Subclinical Hypothyroidism in Down Syndrome
Children's Hospital of Philadelphia
NCT01832753
Down Syndrome Biomarker Initiative (DSBI)
Michael Rafii
NCT02141971
Balance Bike Training in Down Syndrome
University of Mississippi Medical Center
NCT03677245
Feasibility and Dose Tolerability of HD-tDCS in Healthy Adults and Children With Down Syndrome
University of Wisconsin, Madison
NCT02481765
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 8 |
| Phase 3 | 4 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Down Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Down Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Down Syndrome page
55 registered trials, 21 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 21 Down Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Sequenom sponsors the most Down Syndrome trials on record, review their full trial history before evaluating a specific study. See Sequenom's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Down Syndrome condition card totals 55 registered trials; most-linked intervention Cytarabine; top US site state Arizona. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.