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Depressive Disorder, Major: early-phase trial registry
14 of 53 indexed Depressive Disorder, Major trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #265 of 28,707 conditions by registered trial count.
53 US clinical trials · 14 currently recruiting · #265 of 28,707 conditions by registered trial count
Depressive Disorder, Major: 53 US clinical trials tracked, 14 recruiting.
Depressive Disorder, Major is the subject of 53 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Janssen Research & Development, running 11 of these trials.
Enrollment posture brief
Registry condition depressive-disorder-major
OPEN 14 | RECR 26% | LATE 13 | EARLY 22 | RANK #265 | SPON 11
Volume-matched condition peers
Nearest open-share peer: Anatomic Stage IIA Breast Cancer AJCC v8 (26% recruiting · 34 trials)
Depressive Disorder, Major lists 14 open slots (26% of 53 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depressive Disorder, Major on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depressive Disorder, Major is recruiting below its size-band peers.
14 of 53 indexed trials (26.4%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Depressive Disorder, Major research.
Janssen Research & Development accounts for 11 of 53 trials (20.8%). 32 distinct sponsors appear on at least one study for this condition label.
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Typical Depressive Disorder, Major enrolment sits around 124 participants.
Median target enrolment is 124 among the 53 trials that report a genuine target (sentinel values excluded). 23 of those (43.4%) plan for fewer than 100 participants.
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Depressive Disorder, Major research is mostly interventional.
45 interventional and 8 observational studies make up this index (84.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
53 total, page 2 of 2
The Role Of Omega-3 Fatty Acids In Adolescent Depression
Icahn School of Medicine at Mount Sinai
NCT00962598
Abilify as an Adjunctive Treatment for Refractory Depression
St. Luke's-Roosevelt Hospital Center
NCT00220636
Brain Network Dynamics of Depression During Esketamine Treatment
University of North Carolina, Chapel Hill
NCT06012916
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 16 |
| Phase 3 | 12 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Depressive Disorder, Major records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depressive Disorder, Major trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depressive Disorder, Major page
53 registered trials, 14 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 14 Depressive Disorder, Major trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Janssen Research & Development sponsors the most Depressive Disorder, Major trials on record, review their full trial history before evaluating a specific study. See Janssen Research & Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depressive Disorder, Major condition card totals 53 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.