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NCT01748955 · ClinicalTrials.gov registry record · Phase 4
Paroxetine/Bupropion in Depression With Suicide Attempt or Thoughts: fMRI Study
A Phase 4 study of Depression and Suicidal Ideation, sponsored by New York State Psychiatric Institute.
- Completed
- Registry status
- Phase 4
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT01748955: Completed Phase 4 study of Depression and Suicidal Ideation, sponsored by New York State Psychiatric Institute.
NCT01748955 is a Phase 4 study of Depression and Suicidal Ideation that has completed, run by New York State Psychiatric Institute. The registered enrollment target is 15 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01748955, a Phase 4 study of Depression and Suicidal Ideation, has completed, sponsored by New York State Psychiatric Institute.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
This study uses functional magnetic resonance imaging (fMRI) to investigate the effects of two different antidepressant medications (Paxil CR versus Wellbutrin XL) on reward processing in depressed patients who have attempted suicide or are currently experiencing suicidal thoughts.
Primary Outcome
% change in COPE = (Post-treatment COPE - Pre-treatment COPE) / Pre-treatment COPE COPE is measured during Monetary Incentive Delay Task. Task conditions are: Reward= BOLD signal when subject wins 5 cents vs. wins 0 cents Punishment= BOLD signal when subject loses 5cents vs. loses 0 cents
Conditions Studied
Interventions
- DRUG Paroxetine CR for Major Depressive Episode
- DRUG Bupropion XL for Major Depressive Episode
Study Locations (1)
New York
- Columbia University/New York State Psychiatric Institute - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2010-06 |
| Est. Completion | 2015-03 |
| Phase | Phase 4 |
What the finished NCT01748955 record still lists
NCT01748955 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Paroxetine CR for Major Depressive Episode is the first listed.
NCT01748955 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT01748955 about?
NCT01748955 is a clinical study titled "Paroxetine/Bupropion in Depression With Suicide Attempt or Thoughts: fMRI Study". This study uses functional magnetic resonance imaging (fMRI) to investigate the effects of two different antidepressant medications (Paxil CR versus Wellbutrin XL) on reward processing in depressed patients who have attempted suicide or are currently experiencing suicidal thoughts.
What is the current status of trial NCT01748955?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 15 participants. The study started on 2010-06. Estimated completion is 2015-03.
What conditions does trial NCT01748955 study?
This clinical trial studies the following conditions: Depression, Suicidal Ideation.
What interventions are being tested in trial NCT01748955?
The interventions under investigation include: Paroxetine CR for Major Depressive Episode (DRUG), Bupropion XL for Major Depressive Episode (DRUG).
Who is sponsoring clinical trial NCT01748955?
This trial is sponsored by New York State Psychiatric Institute, which has 364 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01748955 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01748955's enrollment target sits among peer trials
15 641st of 679 higher than 33 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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