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Constipation clinical trials
15 of 55 indexed Constipation trials are currently recruiting.
55 US clinical trials · 15 currently recruiting
Constipation is the subject of 55 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 16 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is Mayo Clinic, running 5 of these trials.
The research picture
Constipation has 55 registered US clinical trials, 15 of them open to new participants right now, about 27% of the total.
- 15
- recruiting participants now
- 27%
- of trials open to enrollment
- 16
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Mayo Clinic
Active & Recent Trials
55 total, page 1 of 2
Indiana University Gastrointestinal Motility Diagnosis Registry
Indiana University
NCT04506593
Preop Laxatives in Robotic Urologic Surgery
Chad R. Tracy
NCT05805436
Management of Dyssynergic Defecation
Mayo Clinic
NCT07225803
Understanding Mechanisms of Normal and Disordered Defecation
Mayo Clinic
NCT03842007
Optimization of Postoperative Bowel Habits
Wake Forest University Health Sciences
NCT06335797
Pre-operative Polyethylene Glycol 3350 for Minimally Invasive Urogynecologic Surgery
University Hospitals Cleveland Medical Center
NCT06159777
A Study of Herbal Supplements in Cancer Survivors With Constipation
Memorial Sloan Kettering Cancer Center
NCT07091084
Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen
Indiana University
NCT05821309
Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis
The University of Texas Health Science Center, Houston
NCT05989763
Impact of Weizmannia (Bacillus) Coagulans JBI-YZ6.3 on Gut Health and Fecal Microbiome Changes
Lindenwood University
NCT07388264
Impact of the Inno Cleanse Dietary Supplement on Gut Health and Associated Variables in Healthy Men and Women
University of Memphis
NCT07215351
Assessing Tenapanor as a Treatment of CF-related Constipation.
Massachusetts General Hospital
NCT06810167
Fecobionics in Biofeedback Therapy in Dyssynergia Patients
The California Medical Innovations Institute
NCT05807321
A Study of Microbiome Transplantation for the Treatment of Constipation and/or Significant Bloating in Patients With Systemic Sclerosis
The University of Texas Health Science Center, Houston
NCT06827977
Pyridostigmine for the Treatment of Constipation in Parkinson Disease
University of Vermont Medical Center
NCT05603715
A Study to Assess Maternal and Fetal Outcomes After Taking Prucalopride During Pregnancy
Takeda
NCT04961840
Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks
University of Arizona
NCT07099222
Use of a Squatting Assist Device in Patients With Constipation
Mayo Clinic
NCT02877394
Microbiota Transplant Therapy for Children With Both Autism Spectrum Disorder and Gastrointestinal Disorders
Gut-Brain-Axis Therapeutics
NCT06503978
MTT for Children With ASD Who Have Gastrointestinal Disorders
Arizona State University
NCT04182633
Neostigmine and Glycopyrrolate by Iontophoresis
James J. Peters Veterans Affairs Medical Center
NCT06351995
Study Evaluating Long-Term Safety of MOA-728 in Participants With Opioid-Induced Constipation
Bausch Health Americas
NCT00804141
Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
NCT00256932
An Open Label Study of Chronic Use of BLI400 Laxative in Constipated Adults
Braintree Laboratories
NCT02819310
Extended Use of Polyethyleneglycol3350 Laxative in Constipated Patients
Braintree Laboratories
NCT00153153
An Open Label Study of Chronic Polyethyleneglycol3350 Use in Constipated Patients
Braintree Laboratories
NCT00164125
Treatment of Functional Bowel Disorders
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00006157
Development and Validation of the Automated Evaluation of Gastrointestinal Symptoms (AEGIS) Platform
Cedars-Sinai Medical Center
NCT02436057
Orally Administered ENT-01 for Parkinson's Disease-Related Constipation (KARMET)
Enterin
NCT03781791
Safety and Efficacy of Lubiprostone in Pediatric Patients With Constipation
Sucampo Pharma Americas
NCT00452335
Guideline to Implementation: A Rapid Clinical Care Pathway to Care for Patients Affected by Chronic Constipation
University of Michigan
NCT06352827
Open Label Tolerability Study of ISOThrive Prebiotic Nectar (MIMO) in Subjects With Constipation
ISOThrive
NCT04677634
ISE to Support Constipation Management
Children's Hospital Medical Center, Cincinnati
NCT02977858
Comparison of PolyethyleneGlycol and Placebo for Relief of Constipation From Constipating Medications
Braintree Laboratories
NCT00153127
Perineal Self-Acupressure
University of California, Los Angeles
NCT01867944
Effect of Preoperative Fiber on Postoperative Bowel Function
University of Massachusetts, Worcester
NCT04882995
Sierra High Definition Ano-Rectal Manometry
Augusta University
NCT01300884
Tolerability and Functional Assessment of a Novel Children's Synbiotic
Seed Health
NCT04534036
Fiber Regimens for Constipation Symptoms
University of Texas Southwestern Medical Center
NCT03845673
Preference of Tegaserod vs. PEG 3350 in Patients With Constipation
Novartis
NCT00171522
A Probiotic Blend Reduces Gastrointestinal Symptoms and Positively Impacts Microbiota Modulation in a Randomized Study
The Center for Applied Health Sciences
NCT05614726
Evaluation of Safety and Tolerability of ENT-01 for the Treatment of Parkinson's Disease Related Constipation
Enterin
NCT03047629
Study to Gather Information on the Acceptability of a New Flavor System With Increasing Levels of 2, 4, 6 g or Higher of Mannitol for PEG 3350 in Subjects Having Infrequent Bowel Movements.
Bayer
NCT04534465
Phase 2 Study to Evaluate Safety and Efficacy of RM-131 Administered to Patients With Chronic Constipation
Motus Therapeutics
NCT01781104
Study Evaluating the Safety of MOA-728 Administered Orally to Healthy Subjects
Bausch Health Americas
NCT00311350
Biomarkers for Intestinal Permeability in Patients With Constipation
Mayo Clinic
NCT02246647
AcuGraph and Digestive Symptoms
Logan College of Chiropractic
NCT00846794
Lubiprostone in Patients With Multiple Sclerosis Associated Constipation
University of Rochester
NCT01236534
Fiber Formula Study Among Radiation Oncology Patients
Mayo Clinic
NCT00888147
Biofeedback Treatment for Functional Constipation
University of California, San Francisco
NCT00502957
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 8 |
| Phase 3 | 6 |
| Phase 4 | 10 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Constipation Trial Landscape
55 indexed Constipation studies · 15 recruiting (27%).
Phase mix: 16 late (III/IV) vs 13 early (I/II).
Top sponsor: Mayo Clinic (5 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Constipation?
PlainTrial tracks 55 US clinical trials for Constipation, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Constipation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.