Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Chronic Migraine clinical trials
11 of 18 indexed Chronic Migraine trials are currently recruiting.
18 US clinical trials · 11 currently recruiting
Chronic Migraine is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Ipsen, running 2 of these trials.
The research picture
Chronic Migraine has 18 registered US clinical trials, 11 of them open to new participants right now, about 61% of the total.
- 11
- recruiting participants now
- 61%
- of trials open to enrollment
- 6
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Ipsen
Active & Recent Trials
18 total, page 1 of 1
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
Brown University
NCT05754190
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
Merz Therapeutics
NCT07018713
Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
Stanford University
NCT03231241
A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults
Ipsen
NCT06625060
A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
AbbVie
NCT06810505
Responding With Evidence and Access for Childhood Headaches
Children's Hospital Medical Center, Cincinnati
NCT05889624
Mind Body Balance for Pediatric Migraine
Children's Hospital Medical Center, Cincinnati
NCT04715685
BOTOX® vs. XEOMIN® for Chronic Migraine
Naval Medical Center Camp Lejeune
NCT05598723
Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)
University of Michigan
NCT05769348
Determining the Utility of a Behavioral Intervention in Chronic Migraine
Mayo Clinic
NCT05415020
Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine
Brigham and Women's Hospital
NCT06795867
A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults
Ipsen
NCT06047444
A Study of Galcanezumab (LY2951742) in Participants 12 to 17 Years of Age With Chronic Migraine
Eli Lilly and Company
NCT04616326
Brief Interventions in Chronic Migraine
University of Michigan
NCT05979337
Non-Invasive Neurostimulation for the Prevention of Chronic Migraine
ElectroCore
NCT01667250
Biofeedback-VR for Treatment of Chronic Migraine
University of Washington
NCT05720819
Efficacy of Behavioral Insomnia Treatment for Chronic Migraine
Daniel Riche
NCT01314651
Calcitonin Gene-related Peptide Levels in Chronic Migraine
Cady, Roger, M.D.
NCT01071096
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
| Phase 3 | 5 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Chronic Migraine Trial Landscape
18 indexed Chronic Migraine studies · 11 recruiting (61%).
Phase mix: 6 late (III/IV) vs 1 early (I/II).
Top sponsor: Ipsen (2 trials), 9 others listed. 18 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Chronic Migraine?
PlainTrial tracks 18 US clinical trials for Chronic Migraine, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Chronic Migraine?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.