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ClinicalTrials.gov 11 recruiting now official registry

Chronic Migraine clinical trials

11 of 18 indexed Chronic Migraine trials are currently recruiting.

18 US clinical trials · 11 currently recruiting

Chronic Migraine is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Ipsen, running 2 of these trials.

The research picture

Chronic Migraine has 18 registered US clinical trials, 11 of them open to new participants right now, about 61% of the total.

11
recruiting participants now
61%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
2
top sponsor: Ipsen
Phase 21Phase 35Phase 41

Active & Recent Trials

18 total, page 1 of 1

RECRUITING 800 participants

Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

Brown University

NCT05754190

RECRUITING Phase 3 780 participants

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

Merz Therapeutics

NCT07018713

RECRUITING 700 participants

Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics

Stanford University

NCT03231241

RECRUITING Phase 2 641 participants

A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults

Ipsen

NCT06625060

RECRUITING Phase 3 420 participants

A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

AbbVie

NCT06810505

RECRUITING NA 400 participants

Responding With Evidence and Access for Childhood Headaches

Children's Hospital Medical Center, Cincinnati

NCT05889624

RECRUITING NA 260 participants

Mind Body Balance for Pediatric Migraine

Children's Hospital Medical Center, Cincinnati

NCT04715685

RECRUITING Phase 3 128 participants

BOTOX® vs. XEOMIN® for Chronic Migraine

Naval Medical Center Camp Lejeune

NCT05598723

RECRUITING NA 80 participants

Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)

University of Michigan

NCT05769348

RECRUITING NA 60 participants

Determining the Utility of a Behavioral Intervention in Chronic Migraine

Mayo Clinic

NCT05415020

RECRUITING NA 40 participants

Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine

Brigham and Women's Hospital

NCT06795867

ACTIVE NOT RECRUITING Phase 3 759 participants

A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults

Ipsen

NCT06047444

ACTIVE NOT RECRUITING Phase 3 312 participants

A Study of Galcanezumab (LY2951742) in Participants 12 to 17 Years of Age With Chronic Migraine

Eli Lilly and Company

NCT04616326

ACTIVE NOT RECRUITING NA 300 participants

Brief Interventions in Chronic Migraine

University of Michigan

NCT05979337

COMPLETED NA 59 participants

Non-Invasive Neurostimulation for the Prevention of Chronic Migraine

ElectroCore

NCT01667250

COMPLETED NA 50 participants

Biofeedback-VR for Treatment of Chronic Migraine

University of Washington

NCT05720819

COMPLETED NA 31 participants

Efficacy of Behavioral Insomnia Treatment for Chronic Migraine

Daniel Riche

NCT01314651

COMPLETED Phase 4 20 participants

Calcitonin Gene-related Peptide Levels in Chronic Migraine

Cady, Roger, M.D.

NCT01071096

Phase Distribution

PhaseTrial count
Phase 2 1
Phase 3 5
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Migraine Trial Landscape

18 indexed Chronic Migraine studies · 11 recruiting (61%).

Phase mix: 6 late (III/IV) vs 1 early (I/II).

Top sponsor: Ipsen (2 trials), 9 others listed. 18 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Migraine?

PlainTrial tracks 18 US clinical trials for Chronic Migraine, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Migraine?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.