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ClinicalTrials.gov 7 recruiting now official registry

Central Nervous System Lymphoma clinical trials

7 of 15 indexed Central Nervous System Lymphoma trials are currently recruiting.

15 US clinical trials · 7 currently recruiting

Central Nervous System Lymphoma is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 3 of these trials.

The research picture

Central Nervous System Lymphoma has 15 registered US clinical trials, 7 of them open to new participants right now, about 47% of the total.

7
recruiting participants now
47%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 17Phase 24

Active & Recent Trials

15 total, page 1 of 1

RECRUITING 500 participants

Long-term Follow-up Study of Patients Receiving CAR-T Cells

Medical College of Wisconsin

NCT03375619

RECRUITING Phase 2 248 participants

DALY II USA/ MB-CART2019.1 for DLBCL

Miltenyi Biomedicine

NCT04792489

RECRUITING Phase 1 100 participants

CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies

Medical College of Wisconsin

NCT04186520

RECRUITING 100 participants

Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies

M.D. Anderson Cancer Center

NCT05011045

RECRUITING Phase 1 26 participants

A Study of Epcoritamab and Ibrutinib in People With Central Nervous System Lymphoma (CNSL)

Memorial Sloan Kettering Cancer Center

NCT07082868

RECRUITING Phase 1 20 participants

Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/Mem T-lymphocytes) for the Treatment of Central Nervous System Lymphoma

City of Hope Medical Center

NCT05625594

RECRUITING Phase 1 12 participants

Loncastuximab Tesirine and Rituximab Following Stereotactic Radiosurgery in Patients With Central Nervous System Lymphomas (SOLAR)

University of Utah

NCT06607549

ACTIVE NOT RECRUITING Phase 2 120 participants

Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom

Cellectar Biosciences

NCT02952508

ACTIVE NOT RECRUITING Early Phase 1 58 participants

LTA Pilot Study of Glucarpidase in Patients With Central Nervous System Lymphoma

Memorial Sloan Kettering Cancer Center

NCT03684980

ACTIVE NOT RECRUITING Phase 1 49 participants

Acalabrutinib in CNSL

Dana-Farber Cancer Institute

NCT04906902

ACTIVE NOT RECRUITING Phase 2 48 participants

Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib, and Rituximab (TEDDI-R) in Aggressive B-cell Lymphomas With Secondary Involvement of the Central Nervous System (CNS)

National Cancer Institute (NCI)

NCT03964090

ACTIVE NOT RECRUITING Phase 2 10 participants

A Pilot Study of Acalabrutinib in Relapsed/Refractory Primary and Secondary CNS Lymphomas

UNC Lineberger Comprehensive Cancer Center

NCT04548648

COMPLETED NA 155 participants

Ferumoxytol in Improving MR Imaging in Patients With High-Grade Brain Tumors or Cerebral Metastases

OHSU Knight Cancer Institute

NCT00103038

COMPLETED Phase 1 18 participants

Treatment of Recurrent Primary or Secondary Central Nervous System (CNS) Lymphoma With ALIMTA (Pemetrexed)

Massachusetts General Hospital

NCT00916630

COMPLETED 14 participants

Using a Novel Functional MRI Technique to Evaluate for Neurotoxicity

Memorial Sloan Kettering Cancer Center

NCT03342586

Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Central Nervous System Lymphoma Trial Landscape

15 indexed Central Nervous System Lymphoma studies · 7 recruiting (47%).

Phase mix: 0 late (III/IV) vs 11 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (3 trials), 9 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Central Nervous System Lymphoma?

PlainTrial tracks 15 US clinical trials for Central Nervous System Lymphoma, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Central Nervous System Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.