Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
DALY II USA/ MB-CART2019.1 for DLBCL
NCT04792489 · View on ClinicalTrials.gov ↗
Study Summary
DALY II USA is a phase II, multi-center, single arm study to evaluate the efficacy, safety, and pharmacokinetics of zamtocabtagene autoleucel (MB-CART2019.1) in patients with relapsed and/or refractory diffuse large B cell lymphoma (DLBCL) after receiving at least two lines of therapy. Additional cohorts include subjects with B-cell primary or secondary central nervous system (CNS) lymphoma (PCNSL) and (SCNSL), mantle cell lymphoma (MCL) and Richter's transformation (RT) after receiving at least one line of therapy.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Fludarabine
- DRUG Bendamustine
- BIOLOGICAL zamtocabtagene autoleucel (MB-CART2019.1)
Study Locations (20)
Arizona
- Banner MD Anderson Cancer Center — Gilbert
- Mayo Clinic — Phoenix
California
- UC San Diego Health — La Jolla
- Stanford University — Stanford
Georgia
- Winship Cancer Institute of Emory University — Atlanta
- Georgia Cancer Center at Augusta University — Augusta
Connecticut
- Yale University — New Haven
Florida
- Baptist Health Miami Cancer Institute — Miami
Illinois
- Robert H Lurie Cancer Center — Chicago
Kansas
- University of Kansas Cancer Center — Westwood
Maryland
- University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center — Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 248 participants |
| Start Date | 2021-05-25 |
| Est. Completion | 2028-12-31 |
| Phase | Phase 2 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04792489
The ClinicalTrials.gov registry entry for NCT04792489 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 248 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Miltenyi Biomedicine, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 8 conditions, with Central Nervous System Lymphoma appearing as the primary indexed condition, and to 4 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04792489 reports 20 study locations spanning 17 distinct geographic areas — top geographies include Arizona, California, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04792489 about?
NCT04792489 is a clinical study titled "DALY II USA/ MB-CART2019.1 for DLBCL". DALY II USA is a phase II, multi-center, single arm study to evaluate the efficacy, safety, and pharmacokinetics of zamtocabtagene autoleucel (MB-CART2019.1) in patients with relapsed and/or refractory diffuse large B cell lymphoma (DLBCL) after receiving at least two lines of therapy. Additional co...
What is the current status of trial NCT04792489?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 248 participants. The study started on 2021-05-25. Estimated completion is 2028-12-31.
What conditions does trial NCT04792489 study?
This clinical trial studies the following conditions: Central Nervous System Lymphoma, Mantle Cell Lymphoma (MCL), Transformed Lymphoma, Relapsed Diffuse Large B Cell Lymphoma, Refractory Diffuse Large B Cell Lymphoma (DLBCL). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04792489?
The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), Bendamustine (DRUG), zamtocabtagene autoleucel (MB-CART2019.1) (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04792489?
This trial is sponsored by Miltenyi Biomedicine, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04792489 being conducted?
This trial has 20 study locations across Arizona, California, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.