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ClinicalTrials.gov 6 recruiting now official registry

Carcinoma, Squamous Cell clinical trials

6 of 15 indexed Carcinoma, Squamous Cell trials are currently recruiting.

15 US clinical trials · 6 currently recruiting

Carcinoma, Squamous Cell is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is UNC Lineberger Comprehensive Cancer Center, running 4 of these trials.

The research picture

Carcinoma, Squamous Cell has 15 registered US clinical trials, 6 of them open to new participants right now, about 40% of the total.

6
recruiting participants now
40%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
4
top sponsor: UNC Lineberger Comprehensive Cancer Center
Phase 15Phase 25Phase 32Phase 41

Active & Recent Trials

15 total, page 1 of 1

RECRUITING Phase 1 292 participants

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

Bicara Therapeutics

NCT04429542

RECRUITING 220 participants

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

UNC Lineberger Comprehensive Cancer Center

NCT04564989

RECRUITING 50 participants

Circulating Tumor DNA (ctDNA) in Locally Advanced Head and Neck Squamous Cell Carcinoma

UNC Lineberger Comprehensive Cancer Center

NCT04099290

RECRUITING Phase 1 36 participants

Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC

University of Chicago

NCT06912087

RECRUITING Phase 2 35 participants

Lenvatinib and Pembrolizumab to Treat Patients With Anal or Rectum Cancer That Has Gotten Worse After Initial Treatment

University of Chicago

NCT06669572

RECRUITING Phase 1 30 participants

Intralesional 5-Fluorouracil (5FU), Topical Calcipotriene Treatment for SCC

Melissa Pugliano-Mauro

NCT03370406

ACTIVE NOT RECRUITING Phase 2 80 participants

Cisplatin + Radiation in SCCHN and Correlation With Oxidative Stress Markers

Susanne Arnold

NCT02994069

ACTIVE NOT RECRUITING Phase 2 46 participants

A Study of (Neo)Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Cutaneous Squamous Cell Carcinoma (V940-007)

Merck Sharp & Dohme

NCT06295809

ACTIVE NOT RECRUITING Phase 2 39 participants

Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma

UNC Lineberger Comprehensive Cancer Center

NCT03174275

ACTIVE NOT RECRUITING Phase 1 35 participants

Study of MEDI0562 Prior to Surgical Resection in Head and Neck Squamous Cell Carcinoma (HNSCC) or Melanoma

Providence Health & Services

NCT03336606

COMPLETED Phase 3 1,131 participants

Determine the Efficacy of Topical Tretinoin Cream for the Prevention of Nonmelanoma Skin Cancer

US Department of Veterans Affairs

NCT00007631

COMPLETED Phase 4 954 participants

CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial

VA Office of Research and Development

NCT00847912

COMPLETED Phase 3 450 participants

Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630)

Merck Sharp & Dohme

NCT03833167

COMPLETED Phase 2 195 participants

P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC

UNC Lineberger Comprehensive Cancer Center

NCT03077243

COMPLETED Phase 1 53 participants

A Phase I/II Study of Radiation Therapy, Paclitaxel Poliglumex and Cetuximab in Advanced Head and Neck Cancer

State University of New York - Upstate Medical University

NCT00660218

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 5
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Carcinoma, Squamous Cell Trial Landscape

15 indexed Carcinoma, Squamous Cell studies · 6 recruiting (40%).

Phase mix: 3 late (III/IV) vs 10 early (I/II).

Top sponsor: UNC Lineberger Comprehensive Cancer Center (4 trials), 9 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Carcinoma, Squamous Cell?

PlainTrial tracks 15 US clinical trials for Carcinoma, Squamous Cell, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Carcinoma, Squamous Cell?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.