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NCT04991103 · ClinicalTrials.gov registry record · Phase 2
Minimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE)
A Phase 2 study of Multiple Myeloma and Amyloidosis, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT04991103: Recruiting Phase 2 study of Multiple Myeloma and Amyloidosis, sponsored by University of Alabama at Birmingham.
NCT04991103 is a Phase 2 study of Multiple Myeloma and Amyloidosis that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 40 participants, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04991103, a Phase 2 study of Multiple Myeloma and Amyloidosis, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a phase II interventional study evaluating the use of minimal residual disease by next generation sequencing to defer autologous hematopoietic stem cell transplantation (AHCT) in patients with newly diagnosed multiple myeloma (cohort A) and amyloidosis (cohort B).
Primary Outcome
To determine the feasibility of utilizing post-induction MRD to inform transplant utilization.
Conditions Studied
Interventions
- DRUG DaraVRD/DaraVCD
Study Locations (1)
Alabama
- University of Alabama at Birmingham - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2021-09-22 |
| Est. Completion | 2028-08-27 |
| Phase | Phase 2 |
What NCT04991103 shows while recruiting
NCT04991103 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (93% lower).
The record links to 2 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 1 intervention - of which DaraVRD/DaraVCD is the first listed.
NCT04991103 reports a single indexed study location in Alabama.
Frequently Asked Questions
What is clinical trial NCT04991103 about?
NCT04991103 is a clinical study titled "Minimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE)". This is a phase II interventional study evaluating the use of minimal residual disease by next generation sequencing to defer autologous hematopoietic stem cell transplantation (AHCT) in patients with newly diagnosed multiple myeloma (cohort A) and amyloidosis (cohort B).
What is the current status of trial NCT04991103?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2021-09-22. Estimated completion is 2028-08-27.
What conditions does trial NCT04991103 study?
This clinical trial studies the following conditions: Multiple Myeloma, Amyloidosis.
What interventions are being tested in trial NCT04991103?
The interventions under investigation include: DaraVRD/DaraVCD (DRUG).
Who is sponsoring clinical trial NCT04991103?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04991103 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Myeloma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04991103's enrollment target sits among peer trials
40 289th of 438 higher than 135 of 438 other Multiple Myeloma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Myeloma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
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