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NCT05285813 · ClinicalTrials.gov registry record · Phase 2
A Phase II Study of Vibecotamab (XmAb14045) for MRD- Positive AML and MDS After Hypomethylating Agent Failure
A Phase 2 study of AML and MDS, sponsored by M.D. Anderson Cancer Center.
- Active
- Registry status
- Phase 2
- Development phase
- 42
- Enrollment target
- 1
- Study location
NCT05285813: Active Phase 2 study of AML and MDS, sponsored by M.D. Anderson Cancer Center.
NCT05285813 is a Phase 2 study of AML and MDS that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 42 participants, below the 132-participant average among 29 other AML trials with a reported enrollment target (68% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05285813, a Phase 2 study of AML and MDS, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 42 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a phase II single-center study to evaluate the safety and effectiveness of vibecotamab, a CD3-CD123 bispecific antibody, in patients with acute myeloid leukemia with persistent or recurrent measurable residual disease and in patients with myelodysplastic syndrome that has not responded to or relapsed after conventional therapy
Interventions
- DRUG Acetaminophen
- DRUG Dexamethasone
- DRUG Diphenhydramine
- DRUG Vibecotamab
Study Locations (1)
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 42 participants |
| Start Date | 2022-05-06 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 2 |
What the registry record for NCT05285813 still lists
NCT05285813 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 42 participants, a relatively small participant target, below the 132-participant average among 29 other AML trials with a reported enrollment target (68% lower).
The record links to 2 conditions, with AML appearing as the primary indexed condition, and to 4 interventions - of which Acetaminophen is the first listed.
NCT05285813 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05285813 about?
NCT05285813 is a clinical study titled "A Phase II Study of Vibecotamab (XmAb14045) for MRD- Positive AML and MDS After Hypomethylating Agent Failure". This is a phase II single-center study to evaluate the safety and effectiveness of vibecotamab, a CD3-CD123 bispecific antibody, in patients with acute myeloid leukemia with persistent or recurrent measurable residual disease and in patients with myelodysplastic syndrome that has not responded to or...
What is the current status of trial NCT05285813?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 42 participants. The study started on 2022-05-06. Estimated completion is 2026-12-31.
What conditions does trial NCT05285813 study?
This clinical trial studies the following conditions: AML, MDS.
What interventions are being tested in trial NCT05285813?
The interventions under investigation include: Acetaminophen (DRUG), Dexamethasone (DRUG), Diphenhydramine (DRUG), Vibecotamab (DRUG).
Who is sponsoring clinical trial NCT05285813?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05285813 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Where NCT05285813's enrollment target sits among peer trials
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