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NCT03050268 · ClinicalTrials.gov registry record
Familial Investigations of Childhood Cancer Predisposition
A clinical trial of Acute Leukemia and AML, sponsored by St. Jude Children's Research Hospital.
- Recruiting
- Registry status
- 1,500
- Enrollment target
- 1
- Study location
NCT03050268 is a study of Acute Leukemia and AML that is actively recruiting participants, run by St. Jude Children's Research Hospital. The registered enrollment target is 1,500 participants, above the 422-participant average among 37 other Acute Leukemia trials with a reported enrollment target (255% higher). The trial reports 1 study location across 1 state.
The verdict
NCT03050268, a study of Acute Leukemia and AML, is actively recruiting participants, sponsored by St. Jude Children's Research Hospital.
- RECRUITING
- Registry status
- 1,500 participants
- Enrollment target
- 1
- Study location
Study Summary
NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic counselor or other genetics professional. If you have already had clinical genetic testing and meet eligibility criteria for this study as shown in the Eligibility Section, you may enroll regardless of the results of your clinical genetic testing. While it is well recognized that hereditary factors contribute to the development of a subset of human cancers, the cause for many cancers remains unknown. The application of next generation sequencing (NGS) technologies has expanded knowledge in the field of hereditary cancer predisposition. Currently, more than 100 cancer predisposing genes have been identified, and it is now estimated that approximately 10% of all cancer patients have an underlying genetic predisposition. The purpose of this protocol is to identify novel cancer predisposing genes and/or genetic variants. For this study, the investigators will establish a Data Registry linked to a Repository of biological samples. Health information, blood samples and occasionally leftover tumor samples will be collected from individuals with familial cancer. The investigators will use NGS approaches to find changes in genes that may be important in the development of familial cancer. The information gained from this study may provide new and better ways to diagnose and care for people with hereditary cancer. PRIMARY OBJECTIVE: * Establish a registry of families with clustering of cancer in which clinical data are linked to a repository of cryopreserved blood cells, germline DNA, and tumor tissues from the proband and other family members. SECONDARY OBJECTIVE: * Identify novel cancer predisposing genes and/or genetic variants in families with clustering of cancer for which the unde
Conditions Studied
Study Locations (1)
Tennessee
- St. Jude Children's Research Hospital - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,500 participants |
| Start Date | 2017-04-06 |
| Est. Completion | 2037-03-31 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03050268
The ClinicalTrials.gov registry entry for NCT03050268 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 1,500 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 422-participant average among 37 other Acute Leukemia trials with a reported enrollment target (255% higher). The listed sponsor is St. Jude Children's Research Hospital, which has 410 total studies on file at ClinicalTrials.gov.
The record links to 10 conditions, with Acute Leukemia appearing as the primary indexed condition, and to 0 interventions.
NCT03050268 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.
Frequently Asked Questions
What is clinical trial NCT03050268 about?
NCT03050268 is a clinical study titled "Familial Investigations of Childhood Cancer Predisposition". NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic counselor o...
What is the current status of trial NCT03050268?
This trial is currently recruiting. The enrollment target is 1,500 participants. The study started on 2017-04-06. Estimated completion is 2037-03-31.
What conditions does trial NCT03050268 study?
This clinical trial studies the following conditions: Acute Leukemia, AML, Diamond-Blackfan Anemia, Adrenocortical Carcinoma, Choroid Plexus Carcinoma.
Who is sponsoring clinical trial NCT03050268?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03050268 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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