Xencor

27 total trials 3 currently recruiting 16 completed

Xencor sponsors 27 registered US clinical trials on ClinicalTrials.gov, 3 of them currently recruiting, and 16 completed. 0 of these trials are in Phase 3-4 (later-stage) and 27 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Endometrial Cancer, with 2 trials.

Trial Pipeline

27 total, page 1 of 1

RECRUITING Phase 1

Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis

NCT06619990

RECRUITING Phase 1

Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

NCT06276491

RECRUITING Phase 1

Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma

NCT05433142

ACTIVE NOT RECRUITING Phase 2

A Study of XmAb20717 (Vudalimab)in Patients With Selected Advanced Gynecologic and Genitourinary Malignancies

NCT05032040

NOT YET RECRUITING Phase 1

Phase 1, Safety and Tolerability Study of XmAb541 and XmAb808 in Advanced Solid Tumors

NCT07593092

TERMINATED Phase 1

Study of Vudalimab or Pembrolizumab in Combination With Chemotherapy as First-line Treatment in Patients With Advanced NSCLC

NCT06173505

TERMINATED Phase 1

A Study of XmAb®662 as Monotherapy or in Combination With Pembrolizumab in Advanced Solid Tumors

NCT05996445

COMPLETED Phase 1

Phase 1, First-in-human, Dose-finding and Expansion Study to Evaluate XmAb®808 in Combination With Pembrolizumab in Advanced Solid Tumors

NCT05585034

TERMINATED Phase 1

Multiple Ascending-Dose Study of XmAb®27564 in Patients With Psoriasis or Atopic Dermatitis

NCT06005792

TERMINATED Phase 2

Phase 2 Study of Plamotamab Combined With Tafasitamab Plus Lenalidomide Versus Tafasitamab Plus Lenalidomide in Relapsed or Refractory (R/R) Diffuse Large-cell B-cell Lymphoma (DLBCL)

NCT05328102

COMPLETED Phase 2

XmAb®20717 (Vudalimab) Alone or in Combination With Chemotherapy or Targeted Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer

NCT05005728

TERMINATED Phase 1

Safety and Efficacy of XmAb18087 ± Pembrolizumab in Advanced Merkel Cell Carcinoma or Extensive-stage Small Cell Lung Cancer

NCT04590781

COMPLETED Phase 1

Safety, Tolerability and PK of a Single Subcutaneous Injection of XmAb27564 in Healthy Volunteers

NCT04857866

COMPLETED Phase 1

A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors

NCT03849469

COMPLETED Phase 1

A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3)

NCT03752398

TERMINATED Phase 1

Study Evaluating AMG 424 in Subjects With Multiple Myeloma

NCT03445663

COMPLETED Phase 1

A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors

NCT03517488

COMPLETED Phase 1

A Study of XmAb®18087 in Subjects With NET and GIST

NCT03411915

COMPLETED Phase 1

Study to Evaluate Safety and Tolerability of XmAb13676 (Plamotamab) in Patients With CD20-expressing Hematologic Malignancies

NCT02924402

COMPLETED Phase 1

Safety, Tolerability, and Bioavailability of Subcutaneously Administered XmAb®7195

NCT02881853

COMPLETED Phase 1

PH 1 Study to Evaluate Safety and Tolerability of XmAb14045 in Patients With CD123-expressing Hematologic Malignancies

NCT02730312

COMPLETED Phase 1

XmAb5871 Bioavailability Study

NCT02867098

COMPLETED Phase 2

Study to Evaluate the Effect of XmAb®5871 on Disease Activity in Patients With IgG4-Related Disease (RD)

NCT02725476

COMPLETED Phase 2

A Study of the Effect of XmAb®5871 in Patients With Systemic Lupus Erythematosus

NCT02725515

COMPLETED Phase 1

Safety and Tolerability of XmAb®7195 in Adult Healthy Volunteers and Adult Subjects With a History of Allergic Rhinitis and/or Allergic Conjunctivitis and/or Atopic Dermatitis

NCT02148744

COMPLETED Phase 1

Safety and Tolerability of XmAb®5574 in Chronic Lymphocytic Leukemia

NCT01161511

COMPLETED Phase 1

Safety Study of XmAb®2513 to Treat Hodgkin Lymphoma or Anaplastic Large Cell Lymphoma

NCT00606645

What the Pipeline for Xencor Shows

According to the ClinicalTrials.gov registry, Xencor is linked to 27 US clinical trials across every stage of research activity. Of those, 3 studies are currently recruiting, about 11% of the sponsor's indexed portfolio, and 16 are already marked complete, representing roughly 59% of the total.

The phase mix for Xencor reports 0 late-stage studies (Phase 3 and Phase 4 combined) and 27 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Xencor is Endometrial Cancer with 2 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.