Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis

NCT06619990 · View on ClinicalTrials.gov ↗

Study Summary

Brief summary The Phase 1 study described herein will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of XmAb942 in healthy volunteers (Parts A and B). Part C of this study will be a Phase 2 study to evaluate XmAb942 in participants with ulcerative colitis (UC).

Conditions Studied

Interventions

  • DRUG Placebo
  • BIOLOGICAL XmAb942

Study Locations (20)

Florida

  • Xencor Investigative Site — Bradenton
  • Xencor Investigative Site — Jacksonville
  • Xencor Investigative Site — Kissimmee
  • Xencor Investigative Site — Tampa

Texas

  • Xencor Investigative Site — Denton
  • Xencor Investigative Site — Houston
  • Xencor Investigative Site — Kingwood
  • Xencor Investigative Site — San Antonio

Other

  • Xencor Investigative Site — Sofia
  • Xencor Investigative Site — Zagreb
  • Xencor Investigative Site — Tbilisi

Western Australia

  • Xencor Investigative Site — Joondalup
  • Xencor Investigative Site — Nedlands

Ontario

  • Xencor Investigative Site — London
  • Xencor Investigative Site — Scarborough Village

Arizona

  • Xencor Investigative Site — Scottsdale

North Carolina

  • Xencor Investigative Site — Raleigh

New South Wales

  • Xencor Investigative Site — Wollongong

Trial Details

FieldValue
Enrollment Target 270 participants
Start Date 2024-10-10
Est. Completion 2029-01
Phase Phase 1

Sponsor

Xencor

7 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06619990

The ClinicalTrials.gov registry entry for NCT06619990 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 270 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Xencor, which has 7 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Ulcerative Colitis (UC) appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06619990 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, Texas, Other. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06619990 about?

NCT06619990 is a clinical study titled "Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis". Brief summary The Phase 1 study described herein will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of XmAb942 in healthy volunteers (Parts A and B). Part C of this study will be a Phase 2 study to evaluate XmAb942 in participants with ulcerative colitis (UC).

What is the current status of trial NCT06619990?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 270 participants. The study started on 2024-10-10. Estimated completion is 2029-01.

What conditions does trial NCT06619990 study?

This clinical trial studies the following conditions: Ulcerative Colitis (UC). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06619990?

The interventions under investigation include: Placebo (DRUG), XmAb942 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06619990?

This trial is sponsored by Xencor, which has 7 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06619990 being conducted?

This trial has 20 study locations across Arizona, Florida, North Carolina, Texas, New South Wales. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial